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[4,5,6,7-Tetrabromo-2-(Dimethylamino)-1h-Benzimidazol-1-Yl]acetic Acid

CAS 1085822-09-8Formula C11H9Br4N3O2MW 534.82PubChem 46943415

[4,5,6,7-Tetrabromo-2-(Dimethylamino)-1h-Benzimidazol-1-Yl]acetic Acid, also known as TMCB or Casein Kinase II Inhibitor VI, is a research chemical primarily recognized for its inhibitory activity against Casein Kinase II (CK2).

Loading RDKit molecule structure...
InChIKey: PHAOTASRLQMKBE-UHFFFAOYSA-NC11H9Br4N3O2 | MW 534.82

Chemical Identity

Molecular Formula

C11H9Br4N3O2

Molecular Weight

534.82 g/mol

Exact Mass

534.73873

PubChem CID

46943415

IUPAC Name

2-[4,5,6,7-tetrabromo-2-(dimethylamino)benzimidazol-1-yl]acetic acid

SMILES String

CN(C)c1nc2c(Br)c(Br)c(Br)c(Br)c2n1CC(=O)O

Names & Synonyms

TMCBCK2/ERK8-IN-12-(4,5,6,7-Tetrabromo-2-(dimethylamino)-1H-benzo[d]imidazol-1-yl)acetic acid4,5,6,7-Tetrabromo-2-(dimethylamino)-1H-benzimidazole-1-acetic acidcompound 2c [PMID: 22115617]
Show all synonyms
GTPL8140Casein Kinase II Inhibitor VI, TMCBK66T10827Q27076513[4,5,6,7-Tetrabromo-2-(dimethylamino)-1H-1,3-benzimidazol-1-yl]acetic acid
External Identifiers
CHEMBL1233807orb1710039SCHEMBL1759230DTXSID50677589GLXC-06309FLB10589KTB82209BDBM50359846AKOS024457742AT13627NCGC00387111-01DA-58623MS-29888HY-135906CS-0116229

Catalog Overview

This compound, with CAS number 1085822-09-8, is a complex organic molecule featuring a tetrabrominated benzimidazole core, a dimethylamino group, and an acetic acid moiety. It is widely studied in biochemical research as a potent and selective inhibitor of Casein Kinase II (CK2), a ubiquitous serine/threonine protein kinase involved in various cellular processes including cell growth, proliferation, and survival. Its mechanism of action involves interfering with CK2 activity, making it a valuable tool for investigating CK2-dependent signaling pathways and their roles in health and disease.

Use Context

  • Research chemical sourcing
  • Custom synthesis and catalog availability review
  • COA, SDS, pricing, and fulfillment workflow

Physical Data

Estimated

Estimated / predicted physical property values for catalog reference.

Appearance

White to off-white crystalline powder

Physical State

Solid

Melting Point

205.0 °C

Density

1.9 g/cm³

Water Solubility

Slightly soluble to insoluble

Flash Point

250.0 °C

Applications / Classifications

Research intermediateCustom synthesis building block

Biological Target Reference

No verified biological target assignment. This compound is listed primarily as a research or synthetic intermediate.

Preliminary Safety-Style Reference

Preliminary

Preliminary safety-style information for reference only. Not a supplier SDS.

Handling and Storage
  • Handle all research chemicals, including [4,5,6,7-Tetrabromo-2-(Dimethylamino)-1h-Benzimidazol-1-Yl]acetic Acid, with appropriate personal protective equipment (PPE) such as gloves, eye protection, and a lab coat. Work in a well-ventilated area or fume hood to minimize exposure. Avoid inhalation, ingestion, and skin contact. Refer to the Safety Data Sheet (SDS) for detailed hazard information and emergency procedures. Store in a cool, dry place away from incompatible materials.

Related Products / Graph Discovery

Related products, derivatives, keywords, and application cues for catalog discovery.

Related CAS / Similar Products

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Recommended application cues

Research intermediateCustom synthesis building block

Catalog discovery cues, not supplier-verified claims.

Related HS Code / Compliance

HS Code: 293399GHS Pictograms: GHS07, GHS09Shipment review: Shipment details require review before fulfillment.

Compliance cues are non-linked reference tags and require shipment review.

Catalog navigation

Related catalog entries

Other public CAS pages in this catalog. These links support navigation across additional intermediates and do not imply equivalence, availability, or shared use.

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