5-Chloro-2-hydroxy-6-methyl-4-(trifluoromethyl)nicotinonitrile

5-Chloro-2-hydroxy-6-methyl-4-(trifluoromethyl)nicotinonitrile is a complex organic compound characterized by its nicotinonitrile core, a pyridine ring substituted with a nitrile group. Key substituents include a chlorine atom at position 5, a hydroxyl group at position 2 (which can exist in tautomeric equilibrium with a 2-oxo form, as indicated by its IUPAC name 5-chloro-6-methyl-2-oxo-4-(trifluoromethyl)-1H-pyridine-3-carbonitrile), a methyl group at position 6, and a trifluoromethyl group at position 4. This unique combination of functional groups makes it a versatile intermediate in the synthesis of more complex heterocyclic compounds, particularly within pharmaceutical and agrochemical research. Its trifluoromethyl group can impart specific physicochemical properties, such as increased lipophilicity and metabolic stability, which are often desirable in drug discovery.

• Handle 5-Chloro-2-hydroxy-6-methyl-4-(trifluoromethyl)nicotinonitrile with appropriate personal protective equipment, including gloves, eye protection, and a lab coat. Use in a well-ventilated area or under a fume hood to avoid inhalation. Avoid contact with skin and eyes. In case of contact, rinse immediately with plenty of water. Store in a cool, dry place, away from incompatible materials. Always consult the Safety Data Sheet (SDS) for detailed safety information before use.