3-(Difluoromethyl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile

3-(Difluoromethyl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile, identified by CAS 1220696-59-2, is a highly functionalized organic compound. It combines a difluoromethyl group, a cyano group, and a pinacolborane moiety on a benzene ring. The boronic ester functionality makes it an excellent reagent for carbon-carbon bond formation, especially in palladium-catalyzed Suzuki-Miyaura coupling reactions, allowing for the facile attachment of the difluoromethylated benzonitrile scaffold to various organic substrates. The difluoromethyl group can impart unique physicochemical properties, such as lipophilicity and metabolic stability, to target molecules, while the nitrile group offers further synthetic handles for transformations like hydrolysis to carboxylic acids or reduction to amines. This compound is primarily intended for research and development applications in synthetic chemistry.

• Handle with appropriate personal protective equipment, including gloves, eye protection, and a lab coat. Use in a well-ventilated area or fume hood to avoid inhalation. Avoid contact with skin and eyes. In case of contact, rinse immediately with plenty of water. Store in a cool, dry place, away from incompatible materials. Consult the Safety Data Sheet (SDS) for detailed safety information before use. This product is for research use only and not for human or animal therapeutic or diagnostic use.