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(2-Iodo-6-(trifluoromethyl)pyridin-4-yl)boronic acid

CAS 2225181-30-4Formula C6H4BF3INO2MW 316.81PubChem 133634711

A functionalized pyridine boronic acid derivative, (2-Iodo-6-(trifluoromethyl)pyridin-4-yl)boronic acid is a versatile building block in organic synthesis, particularly useful for Suzuki-Miyaura cross-coupling reactions.

Loading RDKit molecule structure...
InChIKey: UPEWVRKWCJWWRH-UHFFFAOYSA-NC6H4BF3INO2 | MW 316.81

Chemical Identity

Molecular Formula

C6H4BF3INO2

Molecular Weight

316.81 g/mol

Exact Mass

316.93319

PubChem CID

133634711

IUPAC Name

[2-iodo-6-(trifluoromethyl)-4-pyridinyl]boronic acid

SMILES String

OB(O)c1cc(I)nc(C(F)(F)F)c1

Names & Synonyms

2-Iodo-6-(trifluoromethyl)pyridine-4-boronic acid
External Identifiers
CS-35427

Catalog Overview

(2-Iodo-6-(trifluoromethyl)pyridin-4-yl)boronic acid is a highly functionalized pyridine derivative featuring both a boronic acid group and an iodine substituent, alongside a trifluoromethyl group. This compound serves as a valuable intermediate in synthetic organic chemistry, enabling diverse transformations. The boronic acid moiety is particularly amenable to Suzuki-Miyaura cross-coupling reactions, allowing for the formation of new carbon-carbon bonds with aryl or vinyl halides. The iodine atom can also participate in various coupling reactions or be further functionalized.

Use Context

  • Research chemical sourcing
  • Custom synthesis and catalog availability review
  • COA, SDS, pricing, and fulfillment workflow
Read more catalog context

(2-Iodo-6-(trifluoromethyl)pyridin-4-yl)boronic acid is a highly functionalized pyridine derivative featuring both a boronic acid group and an iodine substituent, alongside a trifluoromethyl group. This compound serves as a valuable intermediate in synthetic organic chemistry, enabling diverse transformations. The boronic acid moiety is particularly amenable to Suzuki-Miyaura cross-coupling reactions, allowing for the formation of new carbon-carbon bonds with aryl or vinyl halides. The iodine atom can also participate in various coupling reactions or be further functionalized. The trifluoromethyl group introduces strong electron-withdrawing properties and increased lipophilicity, which can be beneficial in designing novel compounds with specific physicochemical properties. It is intended for Research Use Only (RUO).

Physical Data

Estimated

Estimated / predicted physical property values for catalog reference.

Appearance

White to off-white solid

Physical State

Solid

Melting Point

180.0 °C

Boiling Point

350.0 °C

Density

1.7 g/cm³

Water Solubility

Slightly soluble

Flash Point

180.0 °C

Applications / Classifications

Research intermediateCustom synthesis building block

Biological Target Reference

No verified biological target assignment. This compound is listed primarily as a research or synthetic intermediate.

Preliminary Safety-Style Reference

Preliminary

Preliminary safety-style information for reference only. Not a supplier SDS.

Handling and Storage
  • Handle with appropriate personal protective equipment (PPE) including gloves, eye protection, and a lab coat. Use in a well-ventilated area or fume hood. Avoid inhalation, ingestion, and skin contact. Refer to the Safety Data Sheet (SDS) for detailed hazard information and safe handling procedures. Store in a cool, dry place away from incompatible materials.

Related Products / Graph Discovery

Related products, derivatives, keywords, and application cues for catalog discovery.

Similar products (text references)

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Recommended application cues

Research intermediateCustom synthesis building block

Catalog discovery cues, not supplier-verified claims.

Related HS Code / Compliance

HS Code: 293399GHS Pictograms: GHS07Shipment review: Shipment details require review before fulfillment.

Compliance cues are non-linked reference tags and require shipment review.