2-Cyano-3-fluorophenylboronic acid pinacol ester

2-Cyano-3-fluorophenylboronic acid pinacol ester, with CAS 765916-91-4 and molecular formula C13H15BFNO2, is a highly functionalized arylboronic acid pinacol ester. This compound incorporates a cyano group, a fluorine atom, and a pinacol boronic ester moiety on a benzene ring. The pinacol boronic ester group provides enhanced stability and ease of handling compared to free boronic acids, making it a preferred reagent for various synthetic transformations. It serves as a key intermediate in the synthesis of pharmaceuticals, agrochemicals, and materials science research, enabling the introduction of a 2-cyano-3-fluorophenyl group into target molecules. Its utility is particularly prominent in palladium-catalyzed cross-coupling reactions, such as the Suzuki-Miyaura coupling, for forming carbon-carbon bonds.

• Handle with appropriate personal protective equipment (PPE) including gloves, eye protection, and a lab coat. Use in a well-ventilated area or fume hood to avoid inhalation. Avoid contact with skin and eyes. In case of contact, rinse immediately with plenty of water. Store in a cool, dry place, away from incompatible materials. Consult the Safety Data Sheet (SDS) for detailed hazard information and safe handling procedures. This chemical is for research use only and not for human or animal consumption.