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5-Bromo-2-trifluoromethylpyridine-4-boronic acid

CAS 1072951-57-5Formula C6H4BBrF3NO2MW 269.81PubChem 46739155

5-Bromo-2-trifluoromethylpyridine-4-boronic acid is a functionalized pyridine derivative featuring bromine, a trifluoromethyl group, and a boronic acid moiety. It serves as a versatile building block in organic synthesis, particularly for cross-coupling reactions to introduce complex pyridine structures into target molecules. This compound is for research use only.

Loading RDKit molecule structure...
InChIKey: OBSKOYIEHGFTFF-UHFFFAOYSA-NC6H4BBrF3NO2 | MW 269.81

Chemical Identity

Molecular Formula

C6H4BBrF3NO2

Molecular Weight

269.81 g/mol

Exact Mass

268.94706

PubChem CID

46739155

IUPAC Name

[5-bromo-2-(trifluoromethyl)-4-pyridinyl]boronic acid

SMILES String

OB(O)c1cc(C(F)(F)F)ncc1Br

Names & Synonyms

[5-bromo-2-(trifluoromethyl)pyridin-4-yl]boronic acid5-bromo-2-(trifluoromethyl)pyridine-4-boronic acid[5-bromo-2-(trifluoromethyl)-4-pyridyl]boronic acid5-BROMO-2-(TRIFLUOROMETHYL)PYRIDIN-4-YLBORONIC ACID5-Bromo-2-trifluoromethylpyridine-4-boronicacid
Show all synonyms
F16756F538542
External Identifiers
MFCD11504859DTXSID40674784AKOS015834029AS-47907CS-0178031

Catalog Overview

5-Bromo-2-trifluoromethylpyridine-4-boronic acid (CAS: 1072951-57-5) is a highly functionalized pyridine derivative. It features a pyridine core substituted with a bromine atom, a trifluoromethyl group, and a boronic acid moiety. This combination of functional groups makes it a valuable intermediate in various synthetic routes, particularly in cross-coupling reactions like Suzuki-Miyaura coupling, for constructing complex pyridine-containing molecules. Its trifluoromethyl group can impart unique electronic and steric properties, while the bromine and boronic acid groups offer sites for further derivatization.

Use Context

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  • Custom synthesis and catalog availability review
  • COA, SDS, pricing, and fulfillment workflow
Read more catalog context

5-Bromo-2-trifluoromethylpyridine-4-boronic acid (CAS: 1072951-57-5) is a highly functionalized pyridine derivative. It features a pyridine core substituted with a bromine atom, a trifluoromethyl group, and a boronic acid moiety. This combination of functional groups makes it a valuable intermediate in various synthetic routes, particularly in cross-coupling reactions like Suzuki-Miyaura coupling, for constructing complex pyridine-containing molecules. Its trifluoromethyl group can impart unique electronic and steric properties, while the bromine and boronic acid groups offer sites for further derivatization. It is intended for research use only.

Physical Data

Estimated

Estimated / predicted physical property values for catalog reference.

Appearance

White to off-white crystalline solid

Physical State

Solid

Melting Point

202.0 °C

Boiling Point

288.0 °C

Density

1.7 g/cm³

Water Solubility

0.0708 mol/L

Applications / Classifications

Research intermediateCustom synthesis building block

Biological Target Reference

No verified biological target assignment. This compound is listed primarily as a research or synthetic intermediate.

Preliminary Safety-Style Reference

Preliminary

Preliminary safety-style information for reference only. Not a supplier SDS.

Handling and Storage
  • Handle with appropriate personal protective equipment (PPE) including gloves, eye protection, and a lab coat. Use in a well-ventilated area or fume hood to avoid inhalation. Avoid contact with skin and eyes. Refer to the Safety Data Sheet (SDS) for detailed hazard information and safe handling procedures. Store in a cool, dry place, away from incompatible materials. For research use only.

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