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2-Fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-YL)-5-(trifluoromethyl)pyridine

CAS 1128269-66-8Formula C12H14BF4NO2MW 291.05PubChem 67159100

This compound is a fluorinated pyridine derivative featuring a trifluoromethyl group and a pinacol boronate ester. It serves as a versatile building block in organic synthesis, particularly for creating complex fluorinated molecules for research-use applications.

Loading RDKit molecule structure...
InChIKey: CVCZGFALKKFEQE-UHFFFAOYSA-NC12H14BF4NO2 | MW 291.05

Chemical Identity

Molecular Formula

C12H14BF4NO2

Molecular Weight

291.05 g/mol

Exact Mass

291.105372

PubChem CID

67159100

SMILES String

CC1(C)OB(c2cc(C(F)(F)F)cnc2F)OC1(C)C

Names & Synonyms

2-FLUORO-5-(TRIFLUOROMETHYL)-PYRIDINE-3-BORONIC ACID PINACOL ESTERG71316Z20497516792-fluoro-3-(tetramethyl-1,3,2-dioxaborolan-2-yl)-5-(trifluoromethyl)pyridine
External Identifiers
MFCD13182152SCHEMBL1780770MB12953EN300-12593599

Catalog Overview

2-Fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-YL)-5-(trifluoromethyl)pyridine, identified by CAS 1128269-66-8, is a sophisticated organic compound with the molecular formula C12H14BF4NO2 and a molecular weight of 291.05. It incorporates a pyridine core substituted with a fluorine atom, a trifluoromethyl group, and a 4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl (pinacol boronate) moiety. This structure makes it a valuable functionalized intermediate for advanced synthetic chemistry, enabling the introduction of both fluorine and trifluoromethyl groups, as well as facilitating cross-coupling reactions via the boronate ester.

Use Context

  • Research chemical sourcing
  • Custom synthesis and catalog availability review
  • COA, SDS, pricing, and fulfillment workflow

Physical Data

Estimated

Estimated / predicted physical property values for catalog reference.

Appearance

white to off-white solid

Physical State

solid

Melting Point

95.0 °C

Boiling Point

280.0 °C

Density

1.4 g/cm³

Water Solubility

insoluble

Flash Point

145.0 °C

Applications / Classifications

Research intermediateCustom synthesis building block

Biological Target Reference

No verified biological target assignment. This compound is listed primarily as a research or synthetic intermediate.

Preliminary Safety-Style Reference

Preliminary

Preliminary safety-style information for reference only. Not a supplier SDS.

Handling and Storage
  • Handle with appropriate personal protective equipment, including gloves, eye protection, and a lab coat. Use in a well-ventilated area or fume hood to avoid inhalation. Avoid contact with skin and eyes. In case of contact, rinse immediately with plenty of water. Store in a cool, dry place, away from incompatible materials. Consult the Safety Data Sheet (SDS) for detailed safety information before use.

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