3-Chloro-5-(trifluoromethyl)pyridin-2-ylboronic acid

3-Chloro-5-(trifluoromethyl)pyridin-2-ylboronic acid, with CAS 1208314-89-9, is a highly functionalized pyridine derivative featuring a boronic acid group at the 2-position, a chlorine atom at the 3-position, and a trifluoromethyl group at the 5-position. This compound serves as a key intermediate in synthetic organic chemistry, leveraging the reactivity of the boronic acid moiety for carbon-carbon bond formation. The presence of both electron-withdrawing chlorine and trifluoromethyl groups on the pyridine ring influences its electronic properties, making it a valuable reagent for regioselective and stereoselective synthesis of pharmaceuticals, agrochemicals, and advanced materials. Its unique substitution pattern allows for the introduction of a trifluoromethylated pyridine scaffold into target molecules, which can impart enhanced metabolic stability, lipophilicity, and biological activity.

• Handle 3-Chloro-5-(trifluoromethyl)pyridin-2-ylboronic acid in a well-ventilated area or fume hood. Wear appropriate personal protective equipment, including safety goggles, gloves, and a lab coat, to prevent skin and eye contact. Avoid inhalation of dust or vapors. In case of contact, rinse thoroughly with water. Consult the Safety Data Sheet (SDS) for detailed hazard information and emergency procedures. Store in a cool, dry place, away from incompatible materials.