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3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-(trifluoromethyl)pyridine

CAS 1383625-22-6Formula C12H15BF3NO2MW 273.06PubChem 56924434

This compound is a trifluoromethylated pyridine derivative featuring a pinacol boronic ester group. It serves as a versatile building block in organic synthesis, particularly for cross-coupling reactions, enabling the construction of complex pyridine derivatives for research purposes.

Loading RDKit molecule structure...
InChIKey: BEDDMOXMVCQKNJ-UHFFFAOYSA-NC12H15BF3NO2 | MW 273.06

Chemical Identity

Molecular Formula

C12H15BF3NO2

Molecular Weight

273.06 g/mol

Exact Mass

273.114793

PubChem CID

56924434

SMILES String

CC1(C)OB(c2cccnc2C(F)(F)F)OC1(C)C

Names & Synonyms

2-Trifluoromethyl-pyridine-3-boronic acid pinacol ester2-(TRIFLUOROMETHYL)PYRIDINE-3-BORONIc acid PINACOL ESTER2-(TRIFLUOROMETHYL)PYRIDIN-3-YLBORONIC ACID PINACOL ESTERG63589F618883
Show all synonyms
2-Trifluoromethyl-pyridine-3-boronicacidpinacolester2-Trifluoromethylpyridine-3-boronic acid pinacol esterZ20447555393-(tetramethyl-1,3,2-dioxaborolan-2-yl)-2-(trifluoromethyl)pyridine
External Identifiers
MFCD13182147SCHEMBL9955932IFC62522MB12941CS-29050DB-150694CS-0136070EN300-1425788

Catalog Overview

3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-(trifluoromethyl)pyridine, identified by CAS 1383625-22-6, is a sophisticated organic intermediate. It features a pyridine core substituted with a trifluoromethyl group at position 2 and a pinacol boronic ester at position 3. The trifluoromethyl group imparts unique electronic properties, while the pinacol boronic ester is a highly stable and reactive moiety commonly employed in Suzuki-Miyaura cross-coupling reactions. This compound's structure makes it a valuable building block for introducing both trifluoromethylated pyridine scaffolds and boronic acid functionalities into...

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Read more catalog context

3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-(trifluoromethyl)pyridine, identified by CAS 1383625-22-6, is a sophisticated organic intermediate. It features a pyridine core substituted with a trifluoromethyl group at position 2 and a pinacol boronic ester at position 3. The trifluoromethyl group imparts unique electronic properties, while the pinacol boronic ester is a highly stable and reactive moiety commonly employed in Suzuki-Miyaura cross-coupling reactions. This compound's structure makes it a valuable building block for introducing both trifluoromethylated pyridine scaffolds and boronic acid functionalities into complex molecules during research and development.

Physical Data

Estimated

Estimated / predicted physical property values for catalog reference.

Appearance

White solid

Physical State

Solid

Melting Point

95.0 °C

Boiling Point

280.0 °C

Density

1.3 g/cm³

Water Solubility

Slightly soluble

Flash Point

135.0 °C

Applications / Classifications

Research intermediateCustom synthesis building block

Biological Target Reference

No verified biological target assignment. This compound is listed primarily as a research or synthetic intermediate.

Preliminary Safety-Style Reference

Preliminary

Preliminary safety-style information for reference only. Not a supplier SDS.

Handling and Storage
  • Handle with appropriate personal protective equipment, including gloves, eye protection, and a lab coat. Use in a well-ventilated area or under a fume hood to avoid inhalation. Avoid contact with skin and eyes. In case of contact, rinse immediately with plenty of water. Store in a cool, dry place, away from incompatible materials. Consult the Safety Data Sheet (SDS) for detailed hazard information and safe handling procedures. This product is for research use only and not for human or animal therapeutic or diagnostic use.

Related Products / Graph Discovery

Related products, derivatives, keywords, and application cues for catalog discovery.

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