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2-Chloro-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-4-(trifluoromethyl)pyridine

CAS 1622217-23-5Formula C12H14BClF3NO2MW 307.5PubChem 72214371

This compound is a functionalized pyridine derivative featuring a chloropyridine core, a trifluoromethyl group, and a pinacol boronate ester. It is primarily used as a versatile building block in organic synthesis, particularly in cross-coupling reactions for research purposes.

Loading RDKit molecule structure...
InChIKey: PTEWYLQNWCVNGU-UHFFFAOYSA-NC12H14BClF3NO2 | MW 307.5

Chemical Identity

Molecular Formula

C12H14BClF3NO2

Molecular Weight

307.5 g/mol

Exact Mass

307.075821

PubChem CID

72214371

SMILES String

CC1(C)OB(c2cc(C(F)(F)F)cc(Cl)n2)OC1(C)C

Names & Synonyms

888-656-12-Chloro-4-(trifluoromethyl)pyridine-2-boronic acid pinacol ester2-CHLORO-6-(TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-4-(TRIFLUOROMETHYL)PYRIDINEZ2049751052[6-CHLORO-4-(TRIFLUOROMETHYL)PYRIDIN-2-YL]BORONIC ACID PINACOL ESTER
Show all synonyms
2-chloro-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-4-trifluoromethylpyridine
External Identifiers
RefChem:469523SCHEMBL16535294XPC21723MFCD18753065AB76095AT14580BS-31156CS-0176239EN300-12594408

Catalog Overview

2-Chloro-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-4-(trifluoromethyl)pyridine, identified by CAS 1622217-23-5, is a sophisticated organic intermediate. Its structure combines a chlorinated and trifluoromethylated pyridine ring with a pinacol boronate ester group. This unique combination makes it highly valuable in synthetic chemistry, especially for constructing complex molecules through Suzuki-Miyaura cross-coupling reactions. The boronate ester provides a reactive site for C-C bond formation, while the chloro and trifluoromethyl groups offer opportunities for further functionalization or introduce specific electronic...

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Read more catalog context

2-Chloro-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-4-(trifluoromethyl)pyridine, identified by CAS 1622217-23-5, is a sophisticated organic intermediate. Its structure combines a chlorinated and trifluoromethylated pyridine ring with a pinacol boronate ester group. This unique combination makes it highly valuable in synthetic chemistry, especially for constructing complex molecules through Suzuki-Miyaura cross-coupling reactions. The boronate ester provides a reactive site for C-C bond formation, while the chloro and trifluoromethyl groups offer opportunities for further functionalization or introduce specific electronic properties to target molecules. It is intended for research and development purposes only.

Physical Data

Estimated

Estimated / predicted physical property values for catalog reference.

Appearance

White solid

Physical State

Solid

Melting Point

137.0 °C

Boiling Point

264.0 °C

Density

1.4 g/cm³

Water Solubility

4.17 × 10⁻⁴ mol/L

Flash Point

175.0 °C

Applications / Classifications

Research intermediateCustom synthesis building block

Biological Target Reference

No verified biological target assignment. This compound is listed primarily as a research or synthetic intermediate.

Preliminary Safety-Style Reference

Preliminary

Preliminary safety-style information for reference only. Not a supplier SDS.

Handling and Storage
  • Handle with appropriate personal protective equipment (PPE) including gloves, eye protection, and a lab coat. Use in a well-ventilated area or fume hood to avoid inhalation. Avoid contact with skin and eyes. In case of contact, rinse immediately with plenty of water. Store in a cool, dry place, away from incompatible materials. Consult the Safety Data Sheet (SDS) for detailed safety information before use.

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