Tert-butyl 3-(bromomethyl)-5-methylpiperidine-1-carboxylate

Tert-butyl 3-(bromomethyl)-5-methylpiperidine-1-carboxylate, with CAS 1934683-34-7, is an organic compound characterized by a piperidine ring substituted with a bromomethyl group at position 3 and a methyl group at position 5, with the nitrogen atom protected by a tert-butyl carbamate (Boc) group. Its molecular formula is C12H22BrNO2 and its molecular weight is 292.21 g/mol. This compound serves as a key intermediate in synthetic organic chemistry, enabling the introduction of a bromomethyl functionality into target molecules. The bromine atom is a reactive leaving group, making this compound suitable for various nucleophilic substitution reactions, such as alkylations, to form C-C, C-N, or C-O bonds. The Boc protecting group on the piperidine nitrogen allows for selective manipulation of other functional groups and can be readily removed under acidic conditions to reveal the secondary amine. Researchers utilize this compound in the synthesis of novel pharmaceutical candidates, agrochemicals, and other fine chemicals, leveraging its structural features for regioselective and stereoselective transformations.

• Handle with appropriate personal protective equipment, including gloves, eye protection, and a lab coat. Use in a well-ventilated area or fume hood to avoid inhalation. Avoid contact with skin and eyes. In case of contact, rinse immediately with plenty of water. Store in a cool, dry place, away from incompatible materials. Refer to the Safety Data Sheet (SDS) for comprehensive safety information and emergency procedures.