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[6-Fluoro-2-(trifluoromethyl)pyridin-3-yl]boronic acid

CAS 2096339-79-4Formula C6H4BF4NO2MW 208.91PubChem 91882927

[6-Fluoro-2-(trifluoromethyl)pyridin-3-yl]boronic acid is a fluorinated pyridine derivative featuring a boronic acid group. This compound serves as a versatile building block in organic synthesis, particularly for cross-coupling reactions.

Loading RDKit molecule structure...
InChIKey: UTYJWVSYJDGQQN-UHFFFAOYSA-NC6H4BF4NO2 | MW 208.91

Chemical Identity

Molecular Formula

C6H4BF4NO2

Molecular Weight

208.91 g/mol

Exact Mass

209.027121

PubChem CID

91882927

IUPAC Name

[6-fluoro-2-(trifluoromethyl)-3-pyridinyl]boronic acid

SMILES String

OB(O)c1ccc(F)nc1C(F)(F)F

Names & Synonyms

(6-Fluoro-2-(trifluoromethyl)pyridin-3-yl)boronic acid990-931-76-FLUORO-2-(TRIFLUOROMETHYL)PYRIDINE-3-BORONIC ACIDC6H4BF4NO2[6-fluoro-2-(trifluoromethyl)-3-pyridyl]boronic acid
Show all synonyms
Z1269230610
External Identifiers
RefChem:405042MFCD16611331starbld0021417SCHEMBL29951839WID33979EN300-204032

Catalog Overview

[6-Fluoro-2-(trifluoromethyl)pyridin-3-yl]boronic acid is a valuable research-use chemical characterized by a pyridine ring substituted with a fluorine atom, a trifluoromethyl group, and a boronic acid moiety. The presence of both fluorine and trifluoromethyl groups can impart unique electronic and steric properties, influencing reactivity and biological activity in derived molecules. The boronic acid functionality is highly reactive, making it an excellent precursor for Suzuki-Miyaura cross-coupling reactions, enabling the formation of new carbon-carbon bonds with aryl or vinyl halides. It is widely utilized in the synthesis of...

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Read more catalog context

[6-Fluoro-2-(trifluoromethyl)pyridin-3-yl]boronic acid is a valuable research-use chemical characterized by a pyridine ring substituted with a fluorine atom, a trifluoromethyl group, and a boronic acid moiety. The presence of both fluorine and trifluoromethyl groups can impart unique electronic and steric properties, influencing reactivity and biological activity in derived molecules. The boronic acid functionality is highly reactive, making it an excellent precursor for Suzuki-Miyaura cross-coupling reactions, enabling the formation of new carbon-carbon bonds with aryl or vinyl halides. It is widely utilized in the synthesis of complex organic molecules, including potential pharmaceutical intermediates and agrochemicals, where precise structural modifications are crucial.

Physical Data

Estimated

Estimated / predicted physical property values for catalog reference.

Appearance

White to off-white powder or crystalline solid

Physical State

Solid

Melting Point

145.0 °C

Boiling Point

310.0 °C

Density

1.5 g/cm³

Water Solubility

Slightly soluble

Flash Point

180.0 °C

Applications / Classifications

Research intermediateCustom synthesis building block

Biological Target Reference

No verified biological target assignment. This compound is listed primarily as a research or synthetic intermediate.

Preliminary Safety-Style Reference

Preliminary

Preliminary safety-style information for reference only. Not a supplier SDS.

Handling and Storage
  • Handle [6-Fluoro-2-(trifluoromethyl)pyridin-3-yl]boronic acid in a well-ventilated area or fume hood. Wear appropriate personal protective equipment, including gloves, eye protection, and a lab coat. Avoid inhalation of dust or vapors and direct contact with skin and eyes. In case of contact, rinse thoroughly with water. Store in a cool, dry place, away from incompatible materials. Consult the Safety Data Sheet (SDS) for comprehensive safety information before use.

Related Products / Graph Discovery

Related products, derivatives, keywords, and application cues for catalog discovery.

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