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[6-Cyclopropyl-5-(trifluoromethyl)pyridin-3-yl]boronic acid

CAS 2225173-40-8Formula C9H9BF3NO2MW 230.98PubChem 133554994

[6-Cyclopropyl-5-(trifluoromethyl)pyridin-3-yl]boronic acid is a functionalized intermediate featuring a cyclopropyl group and a trifluoromethyl group on a pyridine ring, primarily used in organic synthesis. It serves as a key building block, especially in Suzuki-Miyaura coupling reactions, for constructing complex molecules in research settings.

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InChIKey: DRAAXUDIDRRPQO-UHFFFAOYSA-NC9H9BF3NO2 | MW 230.98

Chemical Identity

Molecular Formula

C9H9BF3NO2

Molecular Weight

230.98 g/mol

Exact Mass

231.067843

PubChem CID

133554994

IUPAC Name

[6-cyclopropyl-5-(trifluoromethyl)-3-pyridinyl]boronic acid

SMILES String

OB(O)c1cnc(C2CC2)c(C(F)(F)F)c1

Names & Synonyms

(6-Cyclopropyl-5-(trifluoromethyl)pyridin-3-yl)boronic acid6-Cyclopropyl-5-trifluoromethylpyridine-3-boronic acid
External Identifiers
CS-34722CS-0111678EN300-7549152

Catalog Overview

[6-Cyclopropyl-5-(trifluoromethyl)pyridin-3-yl]boronic acid, with CAS number 2225173-40-8 and molecular formula C9H9BF3NO2, is a versatile building block in synthetic organic chemistry. It incorporates a boronic acid functionality, a cyclopropyl substituent, and a trifluoromethyl group on a pyridine core. This unique combination of functional groups makes it particularly useful for cross-coupling reactions, such as the Suzuki-Miyaura coupling, enabling the formation of new carbon-carbon bonds. Its trifluoromethyl group can impart specific electronic and steric properties, influencing reactivity and the properties of final...

Use Context

  • Research chemical sourcing
  • Custom synthesis and catalog availability review
  • COA, SDS, pricing, and fulfillment workflow
Read more catalog context

[6-Cyclopropyl-5-(trifluoromethyl)pyridin-3-yl]boronic acid, with CAS number 2225173-40-8 and molecular formula C9H9BF3NO2, is a versatile building block in synthetic organic chemistry. It incorporates a boronic acid functionality, a cyclopropyl substituent, and a trifluoromethyl group on a pyridine core. This unique combination of functional groups makes it particularly useful for cross-coupling reactions, such as the Suzuki-Miyaura coupling, enabling the formation of new carbon-carbon bonds. Its trifluoromethyl group can impart specific electronic and steric properties, influencing reactivity and the properties of final compounds. Researchers utilize this compound as a key intermediate for synthesizing novel pharmaceutical candidates, agrochemicals, and materials in various research and development applications. It is intended for Research Use Only (RUO).

Physical Data

Estimated

Estimated / predicted physical property values for catalog reference.

Appearance

White to off-white crystalline powder

Physical State

Solid

Melting Point

150.0 °C

Boiling Point

300.0 °C

Density

1.4 g/cm³

Water Solubility

Slightly soluble

Flash Point

220.0 °C

Applications / Classifications

Research intermediateCustom synthesis building block

Biological Target Reference

No verified biological target assignment. This compound is listed primarily as a research or synthetic intermediate.

Preliminary Safety-Style Reference

Preliminary

Preliminary safety-style information for reference only. Not a supplier SDS.

Handling and Storage
  • Handle with appropriate personal protective equipment, including gloves, eye protection, and a lab coat. Use in a well-ventilated area or under a fume hood to avoid inhalation. Avoid contact with skin and eyes. In case of contact, rinse immediately with plenty of water. Store in a cool, dry place, away from incompatible materials. Consult the Safety Data Sheet (SDS) for detailed safety information before use. This product is for Research Use Only and not for human or animal therapeutic or diagnostic use.

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