2-Chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3-(trifluoromethyl)pyridine

2-Chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3-(trifluoromethyl)pyridine, with CAS 741709-67-1, is a highly functionalized pyridine derivative. Its structure incorporates a 2-chloro-3-(trifluoromethyl)pyridine moiety and a 4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl (pinacol boronate) group at the 5-position. This combination makes it a valuable intermediate in synthetic organic chemistry. The pinacol boronate group is a robust and widely utilized functionality for palladium-catalyzed cross-coupling reactions, such as the Suzuki-Miyaura coupling, enabling the formation of new carbon-carbon bonds. The trifluoromethyl group is known for its electron-withdrawing properties and metabolic stability, often incorporated into pharmaceuticals and agrochemicals to modulate physicochemical properties. The chlorine atom provides another site for further functionalization or substitution reactions. This compound is typically employed in the synthesis of complex heterocyclic compounds, natural product analogs, and potential pharmaceutical candidates for research use.

• Handle with appropriate personal protective equipment, including gloves, eye protection, and a lab coat. Use in a well-ventilated area or under a fume hood to avoid inhalation. Avoid contact with skin and eyes. In case of contact, rinse immediately with plenty of water. Store in a cool, dry place, away from incompatible materials. Consult the Safety Data Sheet (SDS) for detailed hazard information and safe handling procedures.