3-methyl-5-(trifluoromethyl)-1H-indole-2-carboxylic acid

3-methyl-5-(trifluoromethyl)-1H-indole-2-carboxylic acid (CAS 854531-37-6) is an organic compound featuring an indole core substituted with a methyl group at position 3, a trifluoromethyl group at position 5, and a carboxylic acid group at position 2. With a molecular formula of C11H8F3NO2 and a molecular weight of 243.18 g/mol, this compound is classified as a heterocycle building block. The presence of the trifluoromethyl group often enhances lipophilicity and can influence the electronic properties and metabolic stability of molecules, making it a valuable motif in drug discovery and agrochemical research. The carboxylic acid functionality allows for various synthetic transformations, including esterification, amide formation, and decarboxylation, enabling its use in the synthesis of more complex chemical structures.

• Handle 3-methyl-5-(trifluoromethyl)-1H-indole-2-carboxylic acid with appropriate personal protective equipment, including gloves, eye protection, and a lab coat. Work in a well-ventilated area or under a fume hood to avoid inhalation. Avoid contact with skin and eyes. In case of contact, rinse immediately with plenty of water. Store in a cool, dry place, away from incompatible materials. Consult the Safety Data Sheet (SDS) for detailed hazard information and safe handling procedures before use.