4-Chloro-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile

4-Chloro-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile, with CAS 863868-19-3 and molecular formula C13H15BClNO2, is a highly functionalized aromatic compound. It incorporates a chlorine atom and a nitrile group on a benzene ring, alongside a 4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl (pinacol boronate) moiety. This structure makes it an excellent reagent for palladium-catalyzed cross-coupling reactions, such as the Suzuki-Miyaura coupling, where the boronate ester acts as a nucleophilic coupling partner. The presence of the nitrile group allows for further derivatization, including hydrolysis to carboxylic acids or reduction to amines, while the chloro substituent can also participate in other coupling reactions or nucleophilic aromatic substitutions. This compound is primarily intended for research and development purposes in synthetic organic chemistry.

• Handle 4-Chloro-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile in a well-ventilated area or fume hood. Wear appropriate personal protective equipment, including safety goggles, gloves, and a lab coat. Avoid inhalation of dust or vapors, and prevent contact with skin and eyes. In case of contact, rinse thoroughly with water. Store in a cool, dry place, away from incompatible materials. Refer to the Safety Data Sheet (SDS) for comprehensive safety information before use.