2-(Piperidin-3-yl)-4-trifluoromethylphenylboronic acid

2-(Piperidin-3-yl)-4-trifluoromethylphenylboronic acid (CAS 2225151-82-4) is a synthetic organic compound with the molecular formula C12H15BF3NO2 and a molecular weight of 273.06 g/mol. It is characterized by a phenylboronic acid core substituted with a trifluoromethyl group at the 4-position and a piperidin-3-yl group at the 2-position. As a functionalized boronic acid, it serves as a key intermediate in various synthetic methodologies. The boronic acid functionality makes it highly reactive in palladium-catalyzed cross-coupling reactions, such as the Suzuki-Miyaura coupling, enabling the construction of complex molecular architectures. The trifluoromethyl group is known to enhance lipophilicity, metabolic stability, and binding affinity in medicinal chemistry applications, while the piperidine ring introduces a basic nitrogen and conformational flexibility. This compound is valuable for researchers engaged in drug discovery, agrochemical development, and materials science, where the precise introduction of trifluoromethylated and nitrogen-containing moieties is desired. It is intended for research use only.

• Handle with appropriate personal protective equipment, including gloves, eye protection, and a lab coat. Use in a well-ventilated area or under a fume hood to avoid inhalation. Avoid contact with skin and eyes. In case of contact, rinse immediately with plenty of water. Store in a cool, dry place, away from incompatible materials. Consult the Safety Data Sheet (SDS) for detailed hazard information and safe handling procedures. For research use only.