2-Trifluoromethyl-5-(piperidin-3-yl)phenylboronic acid

2-Trifluoromethyl-5-(piperidin-3-yl)phenylboronic acid, identified by CAS 2225152-80-5, is a sophisticated organic compound with the molecular formula C12H15BF3NO2 and a molecular weight of 273.06. This molecule combines a phenylboronic acid core with a trifluoromethyl group at the 2-position and a piperidin-3-yl moiety at the 5-position. The presence of the boronic acid functionality makes it highly valuable in Suzuki-Miyaura cross-coupling reactions, a cornerstone of modern synthetic organic chemistry for forming carbon-carbon bonds. The trifluoromethyl group introduces unique electronic and steric properties, often enhancing lipophilicity and metabolic stability in potential drug candidates. The piperidine ring provides a basic nitrogen center and a chiral handle, offering further avenues for functionalization and incorporation into complex molecular architectures. This compound is classified as a functionalized intermediate, making it suitable for advanced research in medicinal chemistry, agrochemistry, and materials science.

• Handle with appropriate personal protective equipment, including gloves, eye protection, and a lab coat. Use in a well-ventilated area or under a fume hood to avoid inhalation. Avoid contact with skin and eyes. In case of contact, rinse immediately with plenty of water. Store in a cool, dry place, away from incompatible materials. Consult the Safety Data Sheet (SDS) for detailed hazard information and safe handling procedures. This product is for research use only and not for human or animal therapeutic or diagnostic use.