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(2-Iodo-6-(trifluoromethyl)pyridin-4-yl)boronic acid

CAS 2225181-30-4Formula C6H4BF3INO2MW 316.81PubChem 133634711

A functionalized pyridine boronic acid derivative, (2-Iodo-6-(trifluoromethyl)pyridin-4-yl)boronic acid is a versatile building block in organic synthesis, particularly useful for Suzuki-Miyaura cross-coupling reactions.

Loading RDKit molecule structure...
InChIKey: UPEWVRKWCJWWRH-UHFFFAOYSA-NC6H4BF3INO2 | MW 316.81

Chemical Identity

Molecular Formula

C6H4BF3INO2

Molecular Weight

316.81 g/mol

Exact Mass

316.93319

PubChem CID

133634711

IUPAC Name

[2-iodo-6-(trifluoromethyl)-4-pyridinyl]boronic acid

SMILES String

OB(O)c1cc(I)nc(C(F)(F)F)c1

Names & Synonyms

2-Iodo-6-(trifluoromethyl)pyridine-4-boronic acid
External Identifiers
CS-35427

Catalog Overview

(2-Iodo-6-(trifluoromethyl)pyridin-4-yl)boronic acid is a highly functionalized pyridine derivative featuring both a boronic acid group and an iodine substituent, alongside a trifluoromethyl group. This compound serves as a valuable intermediate in synthetic organic chemistry, enabling diverse transformations. The boronic acid moiety is particularly amenable to Suzuki-Miyaura cross-coupling reactions, allowing for the formation of new carbon-carbon bonds with aryl or vinyl halides. The iodine atom can also participate in various coupling reactions or be further functionalized.

Use Context

  • Research chemical sourcing
  • Custom synthesis and catalog availability review
  • COA, SDS, pricing, and fulfillment workflow
Read more catalog context

(2-Iodo-6-(trifluoromethyl)pyridin-4-yl)boronic acid is a highly functionalized pyridine derivative featuring both a boronic acid group and an iodine substituent, alongside a trifluoromethyl group. This compound serves as a valuable intermediate in synthetic organic chemistry, enabling diverse transformations. The boronic acid moiety is particularly amenable to Suzuki-Miyaura cross-coupling reactions, allowing for the formation of new carbon-carbon bonds with aryl or vinyl halides. The iodine atom can also participate in various coupling reactions or be further functionalized. The trifluoromethyl group introduces strong electron-withdrawing properties and increased lipophilicity, which can be beneficial in designing novel compounds with specific physicochemical properties. It is intended for Research Use Only (RUO).

Physical Data

Estimated

Estimated / predicted physical property values for catalog reference.

Appearance

White to off-white solid

Physical State

Solid

Melting Point

180.0 °C

Boiling Point

350.0 °C

Density

1.7 g/cm³

Water Solubility

Slightly soluble

Flash Point

180.0 °C

Applications / Classifications

Research intermediateCustom synthesis building block

Biological Target Reference

No verified biological target assignment. This compound is listed primarily as a research or synthetic intermediate.

Preliminary Safety-Style Reference

Preliminary

Preliminary safety-style information for reference only. Not a supplier SDS.

Handling and Storage
  • Handle with appropriate personal protective equipment (PPE) including gloves, eye protection, and a lab coat. Use in a well-ventilated area or fume hood. Avoid inhalation, ingestion, and skin contact. Refer to the Safety Data Sheet (SDS) for detailed hazard information and safe handling procedures. Store in a cool, dry place away from incompatible materials.

Related Products / Graph Discovery

Related products, derivatives, keywords, and application cues for catalog discovery.

Similar products (text references)

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Recommended application cues

Research intermediateCustom synthesis building block

Catalog discovery cues, not supplier-verified claims.

Related HS Code / Compliance

HS Code: 293399GHS Pictograms: GHS07Shipment review: Shipment details require review before fulfillment.

Compliance cues are non-linked reference tags and require shipment review.

Catalog navigation

Other public CAS pages in this catalog. These links support navigation across additional intermediates and do not imply equivalence, availability, or shared use.