N-(2,2,2-Trifluoroethyl)valine

N-(2,2,2-Trifluoroethyl)valine, identified by CAS 271592-91-7, is a synthetic amino acid derivative with the molecular formula C7H12F3NO2 and a molecular weight of 199.17 g/mol. This compound features a valine backbone where the amino group is N-substituted with a 2,2,2-trifluoroethyl moiety. The presence of the trifluoroethyl group imparts unique physicochemical properties, including increased lipophilicity and metabolic stability, which are often desirable in drug discovery and development. As a functionalized intermediate, it serves as a versatile chiral building block for the synthesis of complex organic molecules, including peptides, peptidomimetics, and other biologically active compounds. Its utility lies in its ability to introduce both a chiral center and a trifluoromethyl group into target structures, making it relevant in medicinal chemistry, agrochemistry, and materials science research.

• Handle N-(2,2,2-Trifluoroethyl)valine in a well-ventilated area or fume hood. Wear appropriate personal protective equipment, including safety goggles, gloves, and a lab coat, to prevent skin and eye contact. Avoid inhalation of dust or vapors. In case of contact, rinse thoroughly with water. Consult the Safety Data Sheet (SDS) for comprehensive safety information and emergency procedures. Store in a cool, dry place, tightly sealed, away from incompatible materials.