4-Fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile

4-Fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile, identified by CAS 863868-29-5, is a fluorinated benzonitrile derivative featuring a pinacol boronic ester group. This compound serves as a versatile functionalized intermediate in organic synthesis. Its structure, combining a fluorinated aromatic ring, a nitrile group, and a boronic ester, provides multiple reactive sites, making it highly valuable for constructing complex organic molecules. It is particularly useful in medicinal chemistry and materials science research for efficient carbon-carbon bond formation via palladium-catalyzed cross-coupling reactions, such as the Suzuki-Miyaura coupling.

• Handle 4-Fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile with appropriate personal protective equipment (PPE), including chemical-resistant gloves, safety glasses or goggles, and a lab coat. Ensure use in a well-ventilated area or a chemical fume hood to prevent inhalation. Avoid direct contact with skin and eyes. In case of exposure, immediately flush affected areas with plenty of water and seek medical attention if irritation persists. Store the compound in a cool, dry place, away from incompatible materials, and keep containers tightly closed. Always consult the Safety Data Sheet (SDS) for comprehensive safety and handling guidelines before use.