Chemical Identity
Molecular Formula
C18H25F3N2O2Si
Molecular Weight
386.5 g/mol
Exact Mass
386.163739
PubChem CID
46318197
IUPAC Name
5-(trifluoromethyl)-1-tri(propan-2-yl)silylpyrrolo[2,3-b]pyridine-4-carboxylic acid
SMILES String
CC(C)[Si](C(C)C)(C(C)C)n1ccc2c(C(=O)O)c(C(F)(F)F)cnc21
Names & Synonyms
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External Identifiers
Catalog Overview
This chemical, 5-(Trifluoromethyl)-1-(triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridine-4-carboxylic acid, is a sophisticated building block for advanced organic synthesis. Its structure combines a trifluoromethyl group, known for influencing electronic properties and metabolic stability, with a pyrrolo[2,3-b]pyridine heterocyclic system. The nitrogen atom of the pyrrole is protected by a triisopropylsilyl (TIPS) group, offering selective reactivity and stability during synthetic transformations. The presence of a carboxylic acid group provides a versatile handle for further derivatization, such as esterification, amide formation, or...
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- Research chemical sourcing
- Custom synthesis and catalog availability review
- COA, SDS, pricing, and fulfillment workflow
Read more catalog context
This chemical, 5-(Trifluoromethyl)-1-(triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridine-4-carboxylic acid, is a sophisticated building block for advanced organic synthesis. Its structure combines a trifluoromethyl group, known for influencing electronic properties and metabolic stability, with a pyrrolo[2,3-b]pyridine heterocyclic system. The nitrogen atom of the pyrrole is protected by a triisopropylsilyl (TIPS) group, offering selective reactivity and stability during synthetic transformations. The presence of a carboxylic acid group provides a versatile handle for further derivatization, such as esterification, amide formation, or peptide coupling. This compound is valuable in medicinal chemistry and materials science research for creating novel compounds with specific desired properties.
Physical Data
EstimatedEstimated / predicted physical property values for catalog reference.
Appearance
white solid
Physical State
solid
Melting Point
145.0 °C
Boiling Point
480.0 °C
Density
1.23 g/cm³
Water Solubility
3.02 × 10⁻⁴ mol/L
Flash Point
257.3 °C
Applications / Classifications
Biological Target Reference
No verified biological target assignment. This compound is listed primarily as a research or synthetic intermediate.
Preliminary Safety-Style Reference
PreliminaryPreliminary safety-style information for reference only. Not a supplier SDS.
Handling and Storage
- Handle with appropriate personal protective equipment, including gloves, eye protection, and a lab coat. Use in a well-ventilated area or fume hood to avoid inhalation. Avoid contact with skin and eyes. In case of contact, rinse immediately with plenty of water. Always consult the Safety Data Sheet (SDS) for comprehensive safety information before handling this research chemical.
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