tert-butyl N-(5,5,5-trifluoropent-1-yn-3-yl)carbamate

tert-butyl N-(5,5,5-trifluoropent-1-yn-3-yl)carbamate, with CAS 1301229-61-7 and molecular formula C10H14F3NO2, is a synthetic organic compound classified as a functionalized intermediate. It incorporates a terminal alkyne, a trifluoromethyl group, and a tert-butyl carbamate (Boc) protecting group on a nitrogen atom. The trifluoromethyl group is known to impart unique physicochemical properties, such as increased lipophilicity and metabolic stability, to molecules. The terminal alkyne provides a versatile handle for various click chemistry reactions (e.g., copper-catalyzed azide-alkyne cycloaddition) or other alkyne-based transformations. The Boc group serves as a common protecting group for amines, which can be selectively removed under acidic conditions to reveal a primary amine. This combination of functionalities makes it a useful building block for the synthesis of complex organic molecules, particularly in drug discovery and development, as well as in the creation of novel materials.

• Handle tert-butyl N-(5,5,5-trifluoropent-1-yn-3-yl)carbamate in a well-ventilated area or fume hood. Wear appropriate personal protective equipment, including safety goggles, gloves, and a lab coat. Avoid inhalation, ingestion, and skin contact. Refer to the Safety Data Sheet (SDS) for detailed hazard information and safe handling procedures. Store in a cool, dry place, away from incompatible materials.