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(S)-2-Amino-3-(2-fluoro-4-(trifluoromethyl)phenyl)propanoic acid

CAS 1270137-96-6Formula C10H9F4NO2MW 251.18PubChem 92964034

(S)-2-Amino-3-(2-fluoro-4-(trifluoromethyl)phenyl)propanoic acid is a fluorinated derivative of the essential amino acid L-phenylalanine. It is primarily used in research as a building block for synthesizing peptides, peptidomimetics, or other small molecules, particularly in medicinal chemistry and drug discovery applications.

Loading RDKit molecule structure...
InChIKey: OMTZLRBOGCVOEM-QMMMGPOBSA-NC10H9F4NO2 | MW 251.18

Chemical Identity

Molecular Formula

C10H9F4NO2

Molecular Weight

251.18 g/mol

Exact Mass

251.056941

PubChem CID

92964034

IUPAC Name

(2S)-2-amino-3-[2-fluoro-4-(trifluoromethyl)phenyl]propanoic acid

SMILES String

N[C@@H](Cc1ccc(C(F)(F)F)cc1F)C(=O)O

Names & Synonyms

2-F-4-trifluoromethyl-L-Phe2-Fluoro-4-trifluoromethyl-L-phenylalanine
External Identifiers
MFCD18661747starbld0030752AKOS037653526JS-4330

Catalog Overview

(S)-2-Amino-3-(2-fluoro-4-(trifluoromethyl)phenyl)propanoic acid, also known as 2-Fluoro-4-trifluoromethyl-L-phenylalanine, is a chiral non-proteinogenic amino acid. Its structure incorporates a trifluoromethyl group and a fluorine atom on the phenyl ring, which can impart unique physicochemical properties such as increased lipophilicity, metabolic stability, and altered electronic characteristics. These features make it a valuable tool in synthetic organic chemistry and drug design, where it can be incorporated into peptides or other complex molecules to investigate biological activity, improve pharmacokinetic profiles, or serve...

Use Context

  • Research chemical sourcing
  • Custom synthesis and catalog availability review
  • COA, SDS, pricing, and fulfillment workflow
Read more catalog context

(S)-2-Amino-3-(2-fluoro-4-(trifluoromethyl)phenyl)propanoic acid, also known as 2-Fluoro-4-trifluoromethyl-L-phenylalanine, is a chiral non-proteinogenic amino acid. Its structure incorporates a trifluoromethyl group and a fluorine atom on the phenyl ring, which can impart unique physicochemical properties such as increased lipophilicity, metabolic stability, and altered electronic characteristics. These features make it a valuable tool in synthetic organic chemistry and drug design, where it can be incorporated into peptides or other complex molecules to investigate biological activity, improve pharmacokinetic profiles, or serve as a scaffold for novel research agents for research use.

Physical Data

Estimated

Estimated / predicted physical property values for catalog reference.

Appearance

White crystalline powder

Physical State

Solid

Melting Point

180.0 °C

Boiling Point

380.0 °C

Density

1.5 g/cm³

Water Solubility

Slightly soluble to soluble

Flash Point

230.0 °C

Applications / Classifications

Research intermediateCustom synthesis building block

Biological Target Reference

No verified biological target assignment. This compound is listed primarily as a research or synthetic intermediate.

Preliminary Safety-Style Reference

Preliminary

Preliminary safety-style information for reference only. Not a supplier SDS.

Handling and Storage
  • Handle with appropriate personal protective equipment, including gloves, eye protection, and a lab coat. Use in a well-ventilated area or fume hood to avoid inhalation. Avoid contact with skin and eyes. In case of contact, rinse immediately with plenty of water. Refer to the Safety Data Sheet (SDS) for detailed hazard information and safe handling procedures. Store in a cool, dry place, away from incompatible materials.

Related Products / Graph Discovery

Related products, derivatives, keywords, and application cues for catalog discovery.

Recommended application cues

Research intermediateCustom synthesis building block

Catalog discovery cues, not supplier-verified claims.

Related HS Code / Compliance

HS Code: 292249GHS Pictograms: GHS07Shipment review: Shipment details require review before fulfillment.

Compliance cues are non-linked reference tags and require shipment review.

Catalog navigation

Other public CAS pages in this catalog. These links support navigation across additional intermediates and do not imply equivalence, availability, or shared use.