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3-Chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-(trifluoromethyl)pyridine

CAS 1355067-84-3Formula C12H14BClF3NO2MW 307.5PubChem 66666577

This compound is a functionalized pyridine derivative featuring a chloropyridine core, a trifluoromethyl group, and a pinacol boronate ester. It is primarily used as a versatile building block in organic synthesis, particularly for Suzuki-Miyaura cross-coupling reactions to introduce complex pyridine scaffolds for research purposes.

Loading RDKit molecule structure...
InChIKey: MHAISGYMJXOIKQ-UHFFFAOYSA-NC12H14BClF3NO2 | MW 307.5

Chemical Identity

Molecular Formula

C12H14BClF3NO2

Molecular Weight

307.5 g/mol

Exact Mass

307.075821

PubChem CID

66666577

SMILES String

CC1(C)OB(c2cnc(C(F)(F)F)c(Cl)c2)OC1(C)C

Names & Synonyms

3-chloro-5-(tetramethyl-1,3,2-dioxaborolan-2-yl)-2-(trifluoromethyl)pyridineMHAISGYMJXOIKQ-UHFFFAOYSA-NG67122Z2049765931
External Identifiers
SCHEMBL364117DB-394887CS-0529646EN300-12603761

Catalog Overview

3-Chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-(trifluoromethyl)pyridine, with CAS 1355067-84-3, is a sophisticated organoboron compound. Its structure combines a chlorinated and trifluoromethylated pyridine ring with a pinacol boronate ester. This unique combination makes it a highly valuable intermediate in synthetic chemistry, enabling the formation of new carbon-carbon bonds through palladium-catalyzed cross-coupling reactions. The trifluoromethyl group often imparts specific electronic and steric properties, while the chlorine atom provides another site for further functionalization, making it a versatile building...

Use Context

  • Research chemical sourcing
  • Custom synthesis and catalog availability review
  • COA, SDS, pricing, and fulfillment workflow
Read more catalog context

3-Chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-(trifluoromethyl)pyridine, with CAS 1355067-84-3, is a sophisticated organoboron compound. Its structure combines a chlorinated and trifluoromethylated pyridine ring with a pinacol boronate ester. This unique combination makes it a highly valuable intermediate in synthetic chemistry, enabling the formation of new carbon-carbon bonds through palladium-catalyzed cross-coupling reactions. The trifluoromethyl group often imparts specific electronic and steric properties, while the chlorine atom provides another site for further functionalization, making it a versatile building block for complex molecular architectures in research settings.

Physical Data

Estimated

Estimated / predicted physical property values for catalog reference.

Appearance

white to off-white crystalline powder

Physical State

solid

Melting Point

100.0 °C

Boiling Point

350.0 °C

Density

1.4 g/cm³

Water Solubility

insoluble or sparingly soluble

Flash Point

160.0 °C

Applications / Classifications

Research intermediateCustom synthesis building block

Biological Target Reference

No verified biological target assignment. This compound is listed primarily as a research or synthetic intermediate.

Preliminary Safety-Style Reference

Preliminary

Preliminary safety-style information for reference only. Not a supplier SDS.

Handling and Storage
  • Handle with appropriate personal protective equipment (PPE), including gloves, eye protection, and a lab coat. Use in a well-ventilated area or under a fume hood to avoid inhalation. Avoid contact with skin and eyes. In case of contact, rinse immediately with plenty of water. Store in a cool, dry place, away from incompatible materials. Consult the Safety Data Sheet (SDS) for comprehensive safety information before use. This product is for research use only and not for human or animal therapeutic or diagnostic use.

Related Products / Graph Discovery

Related products, derivatives, keywords, and application cues for catalog discovery.

Similar products (text references)

2-Chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3-(trifluoromethyl)pyridineCAS 741709-67-1
4-Chloro-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-YL)-6-(trifluoromethyl)pyridineCAS 2223047-09-2
2-Chloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-6-(trifluoromethyl)pyridineCAS 1218790-05-6
2-Chloro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-6-(trifluoromethyl)pyridineCAS 2068737-11-9
2-Chloro-5-(trifluoromethyl)pyridine-4-boronic acid pinacol esterCAS 2121515-21-5

Recommended application cues

Research intermediateCustom synthesis building block

Catalog discovery cues, not supplier-verified claims.

Related HS Code / Compliance

HS Code: 293339GHS Pictograms: GHS07Shipment review: Shipment details require review before fulfillment.

Compliance cues are non-linked reference tags and require shipment review.