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2-Chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-4-(trifluoromethyl)pyridine

CAS 2377611-69-1Formula C12H14BClF3NO2MW 307.5PubChem 118992116

2-Chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-4-(trifluoromethyl)pyridine is a functionalized pyridine derivative containing a chlorine atom, a trifluoromethyl group, and a pinacol boronate ester. This compound is primarily used as a versatile building block in organic synthesis, particularly for Suzuki-Miyaura cross-coupling reactions, to introduce the substituted pyridine moiety into various molecular architectures for research and development.

Loading RDKit molecule structure...
InChIKey: SHHWGHPUZRQLJL-UHFFFAOYSA-NC12H14BClF3NO2 | MW 307.5

Chemical Identity

Molecular Formula

C12H14BClF3NO2

Molecular Weight

307.5 g/mol

Exact Mass

307.075821

PubChem CID

118992116

SMILES String

CC1(C)OB(c2cnc(Cl)cc2C(F)(F)F)OC1(C)C

Names & Synonyms

2-Chloro-4-(trifluoromethyl)pyridine-5-boronic acid pinacol ester2-CHLORO-5-(TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-4-(TRIFLUOROMETHYL)PYRIDINE
External Identifiers
MFCD18779930AT14251BS-35203CS-0176739

Catalog Overview

2-Chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-4-(trifluoromethyl)pyridine, identified by CAS 2377611-69-1, is an organoboron compound featuring a pyridine core substituted with a chlorine atom, a trifluoromethyl group, and a pinacol boronate ester. Its molecular formula is C12H14BClF3NO2 and its molecular weight is 307. 50 g/mol. This compound serves as a key intermediate in synthetic chemistry, offering a reactive boronate group for cross-coupling reactions and a halogen for further functionalization.

Use Context

  • Research chemical sourcing
  • Custom synthesis and catalog availability review
  • COA, SDS, pricing, and fulfillment workflow
Read more catalog context

2-Chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-4-(trifluoromethyl)pyridine, identified by CAS 2377611-69-1, is an organoboron compound featuring a pyridine core substituted with a chlorine atom, a trifluoromethyl group, and a pinacol boronate ester. Its molecular formula is C12H14BClF3NO2 and its molecular weight is 307.50 g/mol. This compound serves as a key intermediate in synthetic chemistry, offering a reactive boronate group for cross-coupling reactions and a halogen for further functionalization. The trifluoromethyl group provides electron-withdrawing properties, influencing the reactivity and electronic profile of the pyridine ring. It is typically employed in the synthesis of complex organic molecules, including potential pharmaceutical intermediates and agrochemicals, where precise structural modifications are required for research purposes.

Physical Data

Estimated

Estimated / predicted physical property values for catalog reference.

Appearance

White to off-white crystalline powder

Physical State

Solid

Melting Point

85.0 °C

Boiling Point

280.0 °C

Density

1.4 g/cm³

Water Solubility

Insoluble

Flash Point

145.0 °C

Applications / Classifications

Research intermediateCustom synthesis building block

Biological Target Reference

No verified biological target assignment. This compound is listed primarily as a research or synthetic intermediate.

Preliminary Safety-Style Reference

Preliminary

Preliminary safety-style information for reference only. Not a supplier SDS.

Handling and Storage
  • Handle in a well-ventilated area or under a fume hood. Wear appropriate personal protective equipment (PPE), including safety glasses, chemical-resistant gloves, and a lab coat. Avoid inhalation of dust or vapors. Avoid contact with skin and eyes. In case of contact, rinse immediately with plenty of water and seek medical advice. Store in a cool, dry place, away from incompatible materials. Always refer to the Safety Data Sheet (SDS) for comprehensive safety information before use.

Related Products / Graph Discovery

Related products, derivatives, keywords, and application cues for catalog discovery.

Similar products (text references)

2-Chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3-(trifluoromethyl)pyridineCAS 741709-67-1
3-Chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-(trifluoromethyl)pyridineCAS 1355067-84-3
4-Chloro-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-YL)-6-(trifluoromethyl)pyridineCAS 2223047-09-2
2-Chloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-6-(trifluoromethyl)pyridineCAS 1218790-05-6
2-Chloro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-6-(trifluoromethyl)pyridineCAS 2068737-11-9

Recommended application cues

Research intermediateCustom synthesis building block

Catalog discovery cues, not supplier-verified claims.

Related HS Code / Compliance

HS Code: 293339GHS Pictograms: GHS07Shipment review: Shipment details require review before fulfillment.

Compliance cues are non-linked reference tags and require shipment review.