2-(5,5-Dimethyl-1,3,2-dioxaborinan-2-yl)-5-(trifluoromethyl)benzonitrile

2-(5,5-Dimethyl-1,3,2-dioxaborinan-2-yl)-5-(trifluoromethyl)benzonitrile, identified by CAS 883898-98-4, is a versatile research chemical with the molecular formula C13H13BF3NO2 and a molecular weight of 283.06. This compound incorporates a 5,5-dimethyl-1,3,2-dioxaborinane (neopentyl glycol boronate) moiety, a trifluoromethyl group, and a nitrile group attached to a benzene core. These distinct functional groups make it a valuable building block in complex organic synthesis, particularly for Suzuki-Miyaura cross-coupling reactions where the boronate ester can react with aryl halides or triflates to form new carbon-carbon bonds. The trifluoromethyl group can impart unique electronic and steric properties, while the nitrile group offers further synthetic handles.

• Handle 2-(5,5-Dimethyl-1,3,2-dioxaborinan-2-yl)-5-(trifluoromethyl)benzonitrile in a well-ventilated area or fume hood. Wear appropriate personal protective equipment, including safety goggles, gloves, and a lab coat. Avoid inhalation, ingestion, and skin contact. In case of exposure, seek immediate medical attention. Store in a cool, dry place, away from incompatible materials. Refer to the Safety Data Sheet (SDS) for comprehensive safety information.