2-Trifluoromethylpyridine-5-boronic acid pinacol ester

2-Trifluoromethylpyridine-5-boronic acid pinacol ester, with CAS 1218790-39-6, is a valuable research-use chemical intermediate. It consists of a pyridine core substituted with a trifluoromethyl group at the 2-position and a pinacol boronic ester at the 5-position. The trifluoromethyl group is known for its electron-withdrawing properties and ability to enhance the lipophilicity and metabolic stability of compounds, making this moiety desirable in medicinal chemistry. The pinacol boronic ester functionality is a robust and widely utilized group for carbon-carbon bond formation, most notably through palladium-catalyzed Suzuki-Miyaura cross-coupling reactions. This compound serves as a key reagent for synthesizing complex organic molecules, including potential pharmaceutical candidates and materials, by enabling the facile introduction of the 2-trifluoromethylpyridin-5-yl unit.

• Handle with appropriate personal protective equipment, including gloves, eye protection, and a lab coat. Use in a well-ventilated area or fume hood to avoid inhalation. Avoid contact with skin and eyes. In case of contact, rinse immediately with plenty of water. Store in a cool, dry place, away from incompatible materials. Consult the Safety Data Sheet (SDS) for detailed hazard information and safe handling procedures. For research use only.