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2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-6-(trifluoromethyl)pyridine

CAS 881402-16-0Formula C12H15BF3NO2MW 273.06PubChem 17750499

This compound is a pyridine derivative featuring a trifluoromethyl group and a pinacol boronic ester. It serves as a versatile building block in organic synthesis, particularly for cross-coupling reactions in research and development.

Loading RDKit molecule structure...
InChIKey: VYCMURZUDMLBCG-UHFFFAOYSA-NC12H15BF3NO2 | MW 273.06

Chemical Identity

Molecular Formula

C12H15BF3NO2

Molecular Weight

273.06 g/mol

Exact Mass

273.114793

PubChem CID

17750499

SMILES String

CC1(C)OB(c2cccc(C(F)(F)F)n2)OC1(C)C

Names & Synonyms

6-(Trifluoromethyl)pyridine-2-boronic acid pinacol ester6-(Trifluoromethyl)pyridine-2-boronic acid, pinacol esterF691700Z20448275452-(4,4,5,5-tetramethyl-1,3,2-dioxaborolane-2-yl)-6-(trifluoromethyl)pyridine
Show all synonyms
2-(TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-6-(TRIFLUOROMETHYL)PYRIDINE2-(4 pound not4 pound not5 pound not5-Tetramethyl-1 pound not3 pound not2-dioxaborolan-2-yl)-6-(trifluoromethyl)pyridine
External Identifiers
DTXSID50590547RefChem:251764DTXCID90541311MFCD08061589SCHEMBL584521SCHEMBL29550889AKOS015947257AB43336AT14558BS-24015SY042519DB-350225CS-0175667EN300-1706311

Catalog Overview

2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-6-(trifluoromethyl)pyridine, identified by CAS 881402-16-0, is a sophisticated organic compound with the molecular formula C12H15BF3NO2 and a molecular weight of 273. 06. It incorporates a pyridine core substituted with a highly electron-withdrawing trifluoromethyl group and a pinacol boronic ester moiety. This combination makes it a valuable functionalized intermediate in synthetic chemistry, offering reactivity for various transformations, especially those involving carbon-carbon bond formation.

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Read more catalog context

2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-6-(trifluoromethyl)pyridine, identified by CAS 881402-16-0, is a sophisticated organic compound with the molecular formula C12H15BF3NO2 and a molecular weight of 273.06. It incorporates a pyridine core substituted with a highly electron-withdrawing trifluoromethyl group and a pinacol boronic ester moiety. This combination makes it a valuable functionalized intermediate in synthetic chemistry, offering reactivity for various transformations, especially those involving carbon-carbon bond formation. Its structure allows for precise control in the synthesis of complex molecules for research purposes.

Physical Data

Estimated

Estimated / predicted physical property values for catalog reference.

Appearance

White to off-white crystalline solid

Physical State

Solid

Melting Point

86.0 °C

Boiling Point

262.0 °C

Density

1.35 g/cm³

Water Solubility

1.29 × 10⁻³ mol/L

Flash Point

120.0 °C

Applications / Classifications

Research intermediateCustom synthesis building block

Biological Target Reference

No verified biological target assignment. This compound is listed primarily as a research or synthetic intermediate.

Preliminary Safety-Style Reference

Preliminary

Preliminary safety-style information for reference only. Not a supplier SDS.

Handling and Storage
  • For research use only. Handle with appropriate personal protective equipment, including gloves, eye protection, and a lab coat. Use in a well-ventilated area or fume hood to avoid inhalation. Avoid contact with skin and eyes. In case of contact, rinse immediately with plenty of water. Store in a cool, dry place, away from incompatible materials. Consult the Safety Data Sheet (SDS) for comprehensive safety information before handling.

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