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2,3,4-Trifluoro-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline

CAS 1451391-20-0Formula C12H15BF3NO2MW 273.06PubChem 74789434

2,3,4-Trifluoro-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline is a trifluorinated aniline derivative incorporating a pinacol boronic ester. This research-use chemical is a valuable intermediate for organic synthesis, particularly in palladium-catalyzed cross-coupling reactions to form new carbon-carbon bonds, enabling the creation of diverse fluorinated compounds.

Loading RDKit molecule structure...
InChIKey: ZWFBPKFAOYRZNJ-UHFFFAOYSA-NC12H15BF3NO2 | MW 273.06

Chemical Identity

Molecular Formula

C12H15BF3NO2

Molecular Weight

273.06 g/mol

Exact Mass

273.114793

PubChem CID

74789434

SMILES String

CC1(C)OB(c2cc(F)c(F)c(F)c2N)OC1(C)C

Names & Synonyms

2,3,4-trifluoro-6-(tetramethyl-1,3,2-dioxaborolan-2-yl)aniline(2-Amino-3,4,5-trifluorophenyl)boronic acid pinacol esterF467251
External Identifiers
MFCD23713167SCHEMBL29469246AB92724CS-0175548

Catalog Overview

2,3,4-Trifluoro-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline is a highly fluorinated aromatic amine featuring a pinacol boronic ester group. This compound serves as a versatile building block in organic synthesis, particularly for the construction of complex molecules. The trifluorinated aniline moiety provides unique electronic and steric properties, while the boronic ester enables various cross-coupling reactions, such as Suzuki-Miyaura coupling, for C-C bond formation. It is intended for research use only.

Use Context

  • Research chemical sourcing
  • Custom synthesis and catalog availability review
  • COA, SDS, pricing, and fulfillment workflow

Physical Data

Estimated

Estimated / predicted physical property values for catalog reference.

Appearance

White to off-white solid

Physical State

Solid

Melting Point

120.0 °C

Boiling Point

350.0 °C

Density

1.4 g/cm³

Water Solubility

Slightly soluble

Flash Point

200.0 °C

Applications / Classifications

Research intermediateCustom synthesis building block

Biological Target Reference

No verified biological target assignment. This compound is listed primarily as a research or synthetic intermediate.

Preliminary Safety-Style Reference

Preliminary

Preliminary safety-style information for reference only. Not a supplier SDS.

Handling and Storage
  • Handle 2,3,4-Trifluoro-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline in a well-ventilated area or fume hood. Wear appropriate personal protective equipment, including chemical-resistant gloves, safety glasses or goggles, and a lab coat. Avoid inhalation of dust or vapors, and prevent skin or eye contact. In case of exposure, seek immediate medical attention. Store in a cool, dry place, away from incompatible materials. Always refer to the Safety Data Sheet (SDS) for comprehensive safety information.

Related Products / Graph Discovery

Related products, derivatives, keywords, and application cues for catalog discovery.

Related CAS / Similar Products

3-(Piperidin-3-yl)-5-trifluoromethylphenylboronic acidCAS 2225152-66-72-Trifluoromethylpyridine-5-boronic acid pinacol esterCAS 1218790-39-63-(Tetramethyl-1,3,2-dioxaborolan-2-yl)-5-(trifluoromethyl)pyridineCAS 1084953-47-82-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-6-(trifluoromethyl)pyridineCAS 881402-16-0

Similar products (text references)

2225177-59-1CAS 2225177-59-1

Recommended application cues

Research intermediateCustom synthesis building block

Catalog discovery cues, not supplier-verified claims.

Related HS Code / Compliance

HS Code: 292149GHS Pictograms: GHS07Shipment review: Shipment details require review before fulfillment.

Compliance cues are non-linked reference tags and require shipment review.

Catalog navigation

Related catalog entries

Other public CAS pages in this catalog. These links support navigation across additional intermediates and do not imply equivalence, availability, or shared use.

CAS 1084953-47-83-(Tetramethyl-1,3,2-dioxaborolan-2-yl)-5-(trifluoromethyl)pyridineCAS 881402-16-02-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-6-(trifluoromethyl)pyridineCAS 1218790-39-62-Trifluoromethylpyridine-5-boronic acid pinacol esterCAS 2225152-66-73-(Piperidin-3-yl)-5-trifluoromethylphenylboronic acidCAS 2449264-10-02,3,6-Trifluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-YL)anilineCAS 1096689-46-12-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-4-(trifluoromethyl)pyridineCAS 1310405-06-13-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-4-(trifluoromethyl)pyridineCAS 1383625-22-63-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-(trifluoromethyl)pyridine