5-Trifluoromethylpyridine-2-boronic acid pinacol ester

5-Trifluoromethylpyridine-2-boronic acid pinacol ester (CAS 1101205-23-5, C12H15BF3NO2) is a versatile chemical intermediate for research and development. This compound features a pyridine ring substituted with a trifluoromethyl group at the 5-position and a pinacol boronic ester at the 2-position. The trifluoromethyl group imparts electron-withdrawing properties and enhanced metabolic stability, making it a desirable substituent in medicinal chemistry and agrochemical research. The pinacol boronic ester moiety serves as a stable and reactive handle for various cross-coupling reactions, particularly the Suzuki-Miyaura coupling, facilitating the formation of new carbon-carbon bonds with aryl or heteroaryl halides. This compound is intended for research use only (RUO).

• Handle with appropriate personal protective equipment, including chemical-resistant gloves, safety glasses or goggles, and a lab coat. Ensure use in a well-ventilated area or a fume hood to prevent inhalation. Avoid direct contact with skin and eyes. In case of exposure, rinse affected areas immediately with plenty of water and seek medical attention if irritation persists. Store in a cool, dry place, away from incompatible materials. Always consult the Safety Data Sheet (SDS) for comprehensive safety information and handling procedures before use. For research use only.