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(2-Cyclopropyl-5-(trifluoromethyl)pyridin-3-yl)boronic acid

CAS 2225176-76-9Formula C9H9BF3NO2MW 230.98PubChem 133554662

(2-Cyclopropyl-5-(trifluoromethyl)pyridin-3-yl)boronic acid is a functionalized pyridine derivative featuring a boronic acid group, a cyclopropyl ring, and a trifluoromethyl substituent. It serves as a valuable building block in organic synthesis, particularly for Suzuki-Miyaura cross-coupling reactions, enabling the construction of complex molecules for research purposes.

Loading RDKit molecule structure...
InChIKey: AAEGBUCXRCCILK-UHFFFAOYSA-NC9H9BF3NO2 | MW 230.98

Chemical Identity

Molecular Formula

C9H9BF3NO2

Molecular Weight

230.98 g/mol

Exact Mass

231.067843

PubChem CID

133554662

IUPAC Name

[2-cyclopropyl-5-(trifluoromethyl)-3-pyridinyl]boronic acid

SMILES String

OB(O)c1cc(C(F)(F)F)cnc1C1CC1

Names & Synonyms

2-(Cyclopropyl)-5-(trifluoromethyl)pyridine-3-boronic acid
External Identifiers
CS-35358

Catalog Overview

(2-Cyclopropyl-5-(trifluoromethyl)pyridin-3-yl)boronic acid, identified by CAS 2225176-76-9, is a sophisticated pyridine derivative. This compound features a boronic acid moiety, a cyclopropyl ring, and a trifluoromethyl group, making it a highly versatile and reactive intermediate for advanced organic synthesis. Its boronic acid functionality is particularly useful for forming new carbon-carbon bonds through cross-coupling reactions, such as the Suzuki-Miyaura coupling. The trifluoromethyl group can introduce specific electronic and steric properties, often beneficial for enhancing metabolic stability or lipophilicity in...

Use Context

  • Research chemical sourcing
  • Custom synthesis and catalog availability review
  • COA, SDS, pricing, and fulfillment workflow
Read more catalog context

(2-Cyclopropyl-5-(trifluoromethyl)pyridin-3-yl)boronic acid, identified by CAS 2225176-76-9, is a sophisticated pyridine derivative. This compound features a boronic acid moiety, a cyclopropyl ring, and a trifluoromethyl group, making it a highly versatile and reactive intermediate for advanced organic synthesis. Its boronic acid functionality is particularly useful for forming new carbon-carbon bonds through cross-coupling reactions, such as the Suzuki-Miyaura coupling. The trifluoromethyl group can introduce specific electronic and steric properties, often beneficial for enhancing metabolic stability or lipophilicity in synthesized target molecules. The cyclopropyl group contributes to structural rigidity and can influence molecular conformation. This chemical is intended for research applications requiring complex synthetic building blocks.

Physical Data

Estimated

Estimated / predicted physical property values for catalog reference.

Appearance

White to off-white crystalline solid

Physical State

Solid

Melting Point

145.0 °C

Density

1.35 g/cm³

Water Solubility

Slightly soluble

Flash Point

160.0 °C

Applications / Classifications

Research intermediateCustom synthesis building block

Biological Target Reference

No verified biological target assignment. This compound is listed primarily as a research or synthetic intermediate.

Preliminary Safety-Style Reference

Preliminary

Preliminary safety-style information for reference only. Not a supplier SDS.

Handling and Storage
  • Handle with appropriate personal protective equipment (PPE), including chemical-resistant gloves, eye protection, and a lab coat. Use in a well-ventilated area or a fume hood to prevent inhalation. Avoid direct contact with skin and eyes. In case of exposure, rinse affected areas immediately with plenty of water. Store in a cool, dry place, away from incompatible materials. Always consult the Safety Data Sheet (SDS) for comprehensive hazard information and detailed safe handling procedures. This product is for Research Use Only (RUO).

Related Products / Graph Discovery

Related products, derivatives, keywords, and application cues for catalog discovery.

Similar products (text references)

2225154-87-8CAS 2225154-87-8
1446486-08-3CAS 1446486-08-3

Recommended application cues

Research intermediateCustom synthesis building block

Catalog discovery cues, not supplier-verified claims.

Related HS Code / Compliance

HS Code: 293190GHS Pictograms: GHS07Shipment review: Shipment details require review before fulfillment.

Compliance cues are non-linked reference tags and require shipment review.

Catalog navigation

Other public CAS pages in this catalog. These links support navigation across additional intermediates and do not imply equivalence, availability, or shared use.