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(2-Chloro-5-(trifluoromethyl)pyridin-4-yl)boronic acid

CAS 1167437-28-6Formula C6H4BClF3NO2MW 225.36PubChem 49760478

(2-Chloro-5-(trifluoromethyl)pyridin-4-yl)boronic acid is a functionalized boronic acid derivative featuring a chloropyridine ring substituted with a trifluoromethyl group. It serves as a versatile building block in organic synthesis, particularly in Suzuki-Miyaura cross-coupling reactions for the formation of carbon-carbon bonds, and is used in the development of complex organic molecules for research purposes.

Loading RDKit molecule structure...
InChIKey: GBNMDZQANRHEDY-UHFFFAOYSA-NC6H4BClF3NO2 | MW 225.36

Chemical Identity

Molecular Formula

C6H4BClF3NO2

Molecular Weight

225.36 g/mol

Exact Mass

224.997571

PubChem CID

49760478

IUPAC Name

[2-chloro-5-(trifluoromethyl)-4-pyridinyl]boronic acid

SMILES String

OB(O)c1cc(Cl)ncc1C(F)(F)F

Names & Synonyms

[2-CHLORO-5-(TRIFLUOROMETHYL)PYRIDIN-4-YL]BORONIC ACID2-CHLORO-5-(TRIFLUOROMETHYL)PYRIDINE-4-BORONIC ACIDB-[2-CHLORO-5-(TRIFLUOROMETHYL)-4-PYRIDINYL]-BORONIC ACIDBoronic acid, B-[2-chloro-5-(trifluoromethyl)-4-pyridinyl]-[2-Chloro-5-(trifluoromethyl)-4-pyridyl]boronic acid
Show all synonyms
2-Chloro-5-(trifluoromethyl)-pyridine-4-boronic acidGBNMDZQANRHEDY-UHFFFAOYSA-NP17365F5194062-chloro-5-(trifluoromethyl)-4-pyridylboronic acid(2-chloro-5-(trifluoromethyl)pyridin-4-yl)boronicacid
External Identifiers
MFCD12964588SCHEMBL28486144DTXSID20678225AKOS024262996AB66531AS-53982SY100342CS-0053010

Catalog Overview

(2-Chloro-5-(trifluoromethyl)pyridin-4-yl)boronic acid, with CAS 1167437-28-6, is a highly functionalized boronic acid. Its structure incorporates a pyridine core bearing a chlorine atom, a trifluoromethyl group, and a boronic acid moiety. This combination of functional groups makes it a valuable reagent in synthetic chemistry. The boronic acid group is highly reactive in various coupling reactions, while the chloro and trifluoromethyl substituents can introduce specific electronic and steric properties to target molecules.

Use Context

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  • Custom synthesis and catalog availability review
  • COA, SDS, pricing, and fulfillment workflow
Read more catalog context

(2-Chloro-5-(trifluoromethyl)pyridin-4-yl)boronic acid, with CAS 1167437-28-6, is a highly functionalized boronic acid. Its structure incorporates a pyridine core bearing a chlorine atom, a trifluoromethyl group, and a boronic acid moiety. This combination of functional groups makes it a valuable reagent in synthetic chemistry. The boronic acid group is highly reactive in various coupling reactions, while the chloro and trifluoromethyl substituents can introduce specific electronic and steric properties to target molecules. It is typically employed as a key intermediate in the synthesis of complex organic molecules, including pharmaceuticals and agrochemicals, where the pyridine scaffold and trifluoromethyl group are desired structural motifs. This compound is intended for research use only.

Physical Data

Estimated

Estimated / predicted physical property values for catalog reference.

Appearance

white crystalline solid

Physical State

solid

Melting Point

202.0 °C

Boiling Point

294.0 °C

Density

1.55 g/cm³

Water Solubility

0.234 mol/L

Applications / Classifications

Research intermediateCustom synthesis building block

Biological Target Reference

No verified biological target assignment. This compound is listed primarily as a research or synthetic intermediate.

Preliminary Safety-Style Reference

Preliminary

Preliminary safety-style information for reference only. Not a supplier SDS.

Handling and Storage
  • Handle with appropriate personal protective equipment, including gloves, eye protection, and a lab coat. Use in a well-ventilated area or under a fume hood to avoid inhalation of dust or vapors. Avoid contact with skin and eyes. In case of contact, rinse immediately with plenty of water. Store in a cool, dry place, away from incompatible materials. Consult the Safety Data Sheet (SDS) for detailed hazard information and safe handling procedures. This product is for research use only.

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