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[5-Amino-2-fluoro-3-(trifluoromethyl)phenyl]boronic acid

CAS 2377608-24-5Formula C7H6BF4NO2MW 222.93PubChem 75537206

[5-Amino-2-fluoro-3-(trifluoromethyl)phenyl]boronic acid is a fluorinated and trifluoromethyl-substituted aminophenylboronic acid. It serves as a versatile building block in organic synthesis, particularly for creating complex molecules through reactions like Suzuki-Miyaura coupling, for research-use applications.

Loading RDKit molecule structure...
InChIKey: DQEYZNDYUUWUNB-UHFFFAOYSA-NC7H6BF4NO2 | MW 222.93

Chemical Identity

Molecular Formula

C7H6BF4NO2

Molecular Weight

222.93 g/mol

Exact Mass

223.042771

PubChem CID

75537206

SMILES String

Nc1cc(B(O)O)c(F)c(C(F)(F)F)c1

Names & Synonyms

(5-Amino-2-fluoro-3-(trifluoromethyl)phenyl)boronic acidC7H6BF4NO2
External Identifiers
MFCD22421488CS-0177314

Catalog Overview

[5-Amino-2-fluoro-3-(trifluoromethyl)phenyl]boronic acid is an aromatic boronic acid featuring a phenyl ring functionalized with an amino group, a fluorine atom, and a trifluoromethyl group. The boronic acid moiety makes it highly reactive in cross-coupling reactions, while the amino, fluoro, and trifluoromethyl substituents introduce specific electronic and steric properties. This compound is valuable in medicinal chemistry and materials science for synthesizing novel compounds with tailored properties for research-use applications.

Use Context

  • Research chemical sourcing
  • Custom synthesis and catalog availability review
  • COA, SDS, pricing, and fulfillment workflow

Physical Data

Estimated

Estimated / predicted physical property values for catalog reference.

Appearance

White crystalline solid

Physical State

Solid

Melting Point

150.0 °C

Boiling Point

320.0 °C

Density

1.5 g/cm³

Water Solubility

Slightly soluble

Flash Point

190.0 °C

Applications / Classifications

Research intermediateCustom synthesis building block

Biological Target Reference

No verified biological target assignment. This compound is listed primarily as a research or synthetic intermediate.

Preliminary Safety-Style Reference

Preliminary

Preliminary safety-style information for reference only. Not a supplier SDS.

Handling and Storage
  • Handle with appropriate personal protective equipment (PPE) including gloves, eye protection, and a lab coat. Use in a well-ventilated area or fume hood to avoid inhalation. Avoid contact with skin and eyes. In case of contact, rinse immediately with plenty of water. Store in a cool, dry place, away from incompatible materials. Consult the Safety Data Sheet (SDS) for detailed safety information.

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