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(2-Chloro-6-(trifluoromethyl)pyridin-3-yl)boronic acid

CAS 205240-63-7Formula C6H4BClF3NO2MW 225.36PubChem 21865043

(2-Chloro-6-(trifluoromethyl)pyridin-3-yl)boronic acid is a boronic acid derivative featuring a chlorotrifluoromethylpyridine core. It is primarily used as a versatile building block in organic synthesis, particularly in cross-coupling reactions for the construction of complex molecules in research settings.

Loading RDKit molecule structure...
InChIKey: MFBLIMAUCMIBMM-UHFFFAOYSA-NC6H4BClF3NO2 | MW 225.36

Chemical Identity

Molecular Formula

C6H4BClF3NO2

Molecular Weight

225.36 g/mol

Exact Mass

224.997571

PubChem CID

21865043

IUPAC Name

[2-chloro-6-(trifluoromethyl)-3-pyridinyl]boronic acid

SMILES String

OB(O)c1ccc(C(F)(F)F)nc1Cl

Names & Synonyms

2-CHLORO-6-(TRIFLUOROMETHYL)PYRIDINE-3-BORONIC ACID2-Trifluoromethyl-6-chloro-5-pyridineboric acid2-Chloro-6-trifluoromethylpyridine-3-boronic acid[2-Chloro-6-(trifluoromethyl)pyridin-3-yl]boronic acid2-CHLORO-6-(TRIFLUOROMETHYL)PYRIDIN-3-YLBORONIC ACID
Show all synonyms
Boronic acid, [2-chloro-6-(trifluoromethyl)-3-pyridinyl]- (9CI)[2-chloro-6-(trifluoromethyl)-3-pyridyl]boronic acidBoronic acid, [2-chloro-6-(trifluoromethyl)-3-pyridinyl]-2-Chloro-6-trifluoromethylpyridin-3-bronic aicd2-Chloro-6-(trifluoromethyl)pyridine-3-boronicAcidMFBLIMAUCMIBMM-UHFFFAOYSA-N2-Chloro-6-trifluoromethylpyridine-3-boronic aicdF233344
External Identifiers
MFCD10696211SCHEMBL1040845SCHEMBL29951212DTXSID90619049AKOS005063809AB56762AS-31070SY008546DB-010489CS-0136609EN300-1662379

Catalog Overview

(2-Chloro-6-(trifluoromethyl)pyridin-3-yl)boronic acid, identified by CAS 205240-63-7, is a highly functionalized pyridine derivative. It contains a boronic acid group, a chlorine atom, and a trifluoromethyl group attached to a pyridine ring. With a molecular formula of C6H4BClF3NO2 and a molecular weight of 225. 36, this compound serves as a key intermediate in synthetic organic chemistry.

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Read more catalog context

(2-Chloro-6-(trifluoromethyl)pyridin-3-yl)boronic acid, identified by CAS 205240-63-7, is a highly functionalized pyridine derivative. It contains a boronic acid group, a chlorine atom, and a trifluoromethyl group attached to a pyridine ring. With a molecular formula of C6H4BClF3NO2 and a molecular weight of 225.36, this compound serves as a key intermediate in synthetic organic chemistry. Its boronic acid functionality makes it particularly useful in Suzuki-Miyaura cross-coupling reactions, enabling the formation of new carbon-carbon bonds with aryl halides or triflates. The presence of the chloro and trifluoromethyl groups provides opportunities for further functionalization and introduces specific electronic and steric properties, making it valuable for synthesizing novel pharmaceutical candidates, agrochemicals, and materials in research and development.

Physical Data

Estimated

Estimated / predicted physical property values for catalog reference.

Appearance

white solid

Physical State

solid

Melting Point

209.0 °C

Boiling Point

294.0 °C

Density

1.65 g/cm³

Water Solubility

0.224 mol/L

Flash Point

251.5 °C

Applications / Classifications

Research intermediateCustom synthesis building block

Biological Target Reference

No verified biological target assignment. This compound is listed primarily as a research or synthetic intermediate.

Preliminary Safety-Style Reference

Preliminary

Preliminary safety-style information for reference only. Not a supplier SDS.

Handling and Storage
  • For research use only. Handle with appropriate personal protective equipment, including gloves, eye protection, and a lab coat. Use in a well-ventilated area or under a fume hood to avoid inhalation. Avoid contact with skin and eyes. In case of contact, rinse immediately with plenty of water. Store in a cool, dry place, away from incompatible materials. Consult the Safety Data Sheet (SDS) for detailed hazard information and safe handling procedures.

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