Research chemical
CAS Number: 1000358-65-5
Product details
For laboratory research and professional procurement workflows.
PubChem CID
4927
Exact Mass
284.13472
InChIKey
PWWVAXIEGOYWEE-UHFFFAOYSA-N
IUPAC Name
N,N-dimethyl-1-phenothiazin-10-ylpropan-2-amine
SMILES String
CC(CN1C2=CC=CC=C2SC3=CC=CC=C31)N(C)C
Appearance
Catalog navigation
Other public CAS pages in this catalog. These links support navigation across additional intermediates and do not imply equivalence, availability, or shared use.
Promethazine is identified by CAS 1000358-65-5, with molecular formula C17H20N2S, molecular weight 284.4, InChIKey PWWVAXIEGOYWEE-UHFFFAOYSA-N.
ChEMBL contains qualifying experimental assay evidence associated with Histamine H1 receptor, Muscarinic acetylcholine receptor M1, Muscarinic acetylcholine receptor M3, 5-hydroxytryptamine receptor 2C, Muscarinic acetylcholine receptor M2. These records do not establish therapeutic efficacy or clinical use.
Yes. Submit an RFQ and specify COA requirements. Lot-specific COA depends on supplier confirmation.
Yes. Supplier SDS can be requested through the RFQ workflow before handling, storage, shipment, or procurement decisions.
Availability, pack size, lead time, and pricing are confirmed through RFQ.
Crystals. Melting point 60 °C. Used as an antihistamine.
Melting Point
60.0 °C
Boiling Point
190–192.78 °C
XLogP
4.8
Properties are provided as catalog reference data and may be confirmed through supplier documentation when required.
Heavy atom count
20
H-bond acceptors
2
H-bond donors
0
Rotatable bonds
3
Ring count
3
Aromatic rings
2
Topological polar surface area
6.48 Ų
Computed LogP
4.24
Fragment-like structure rule
Yes
Lead-like structure rule
No
Drug-like structure rule
Yes
Structure family
n heterocycle ligand
Precious metal motif
No
Transition metal motif
No
Phosphine ligand motif
No
N-heterocycle motif
Yes
Boronic acid motif
No
Computed structure descriptors generated from molecular structure. These are not experimental physical property values, supplier specifications, SDS data, or bioactivity claims.
Structural features
Promethazine (CAS 1000358-65-5) is an English MolGraph catalog reference, molecular formula C17H20N2S and molecular weight 284. 40 g/mol.
Sourcing context
Catalog reference for RFQ preparation, supplier confirmation, and research chemical sourcing review.
Research use context
Use this page to review identity data, application tags, sourcing readiness, and RFQ context for heterocyclic building-block research, bioactivity screening workflows, research chemical sourcing.
Documentation needs
Request supplier-issued SDS/COA before handling, storage, shipment, or procurement decisions. Public page content is for research catalog reference and does not replace supplier-issued safety documentation.
ChEMBL reports experimental activity evidence for: Histamine H1 receptor (Homo sapiens) — 3 assays; Muscarinic acetylcholine receptor M1 (Homo sapiens) — 3 assays; Muscarinic acetylcholine receptor M3 (Homo sapiens) — 2 assays; 5-hydroxytryptamine receptor 2C (Homo sapiens) — 2 assays; Muscarinic acetylcholine receptor M2 (Homo sapiens) — 5 assays. These records describe research assays and do not establish therapeutic efficacy or clinical use.
Histamine H1 receptor
Homo sapiens · SINGLE PROTEIN · 3 qualifying assays · 3 documents · best pChEMBL 9.48
Experimental evidence source: ChEMBL
Muscarinic acetylcholine receptor M1
Homo sapiens · SINGLE PROTEIN · 3 qualifying assays · 2 documents · best pChEMBL 8.48
Experimental evidence source: ChEMBL
Muscarinic acetylcholine receptor M3
Homo sapiens · SINGLE PROTEIN · 2 qualifying assays · 2 documents · best pChEMBL 8.38
Experimental evidence source: ChEMBL
5-hydroxytryptamine receptor 2C
Homo sapiens · SINGLE PROTEIN · 2 qualifying assays · 2 documents · best pChEMBL 8.19
Experimental evidence source: ChEMBL
Muscarinic acetylcholine receptor M2
Homo sapiens · SINGLE PROTEIN · 5 qualifying assays · 2 documents · best pChEMBL 7.92
Experimental evidence source: ChEMBL
Safety and handling reference content is available through documentation requests.
For supplier-issued SDS, request documentation before handling, storage, shipment, or procurement decisions.
Preliminary Safety Reference
For supplier-issued SDS or COA, submit a documentation request.
Safety Reference / SDS RequestSubmit the CAS number, quantity, purity requirement, and destination country for sourcing review.
Supplier Safety Data Sheet (SDS): By request
Purity and pack size confirmation: By request
Availability and lead time review: Confirmed by RFQ
Shipment documentation review: By request
For supplier-issued documentation by request, use the RFQ actions on this page.Review preliminary safety reference