Research chemical

Tivantinib

CAS Number: 1000873-98-2

Product details

Identity & specification

Molecular formula: C23H19N3O2
Molecular weight: 369.4 g/mol
Product type: Research-use catalog compound
Documentation: COA / SDS available by request

For laboratory research and professional procurement workflows.

Technical identifiers

Show PubChem, InChIKey, IUPAC, and SMILES

PubChem CID

11494412

Exact Mass

369.147727

InChIKey

UCEQXRCJXIVODC-PMACEKPBSA-N

IUPAC Name

(3R,4R)-3-(1-azatricyclo[6.3.1.04,12]dodeca-2,4,6,8(12)-tetraen-3-yl)-4-(1H-indol-3-yl)pyrrolidine-2,5-dione

SMILES String

O=C1NC(=O)[C@@H](c2cn3c4c(cccc24)CCC3)[C@@H]1c1c[nH]c2ccccc12

Physical Properties

No physical property values available.

Show more physical data

XLogP

2.9

Properties are provided as catalog reference data and may be confirmed through supplier documentation when required.

Computed Structure Descriptors

Show calculated structure fields

Heavy atom count

H-bond acceptors

H-bond donors

Rotatable bonds

Ring count

Aromatic rings

Topological polar surface area

66.89 Å²

Computed LogP

3.59

Fragment-like structure rule

Lead-like structure rule

Drug-like structure rule

Yes

Structure family

n heterocycle ligand

Precious metal motif

Transition metal motif

Phosphine ligand motif

N-heterocycle motif

Yes

Boronic acid motif

Computed structure descriptors generated from molecular structure. These are not experimental physical property values, supplier specifications, SDS data, or bioactivity claims.

Catalog Facts

Structural features

Tivantinib (CAS 1000873-98-2) is an English MolGraph catalog reference, molecular formula C23H19N3O2 and molecular weight 369. 40 g/mol.

Sourcing context

Catalog reference for RFQ preparation, supplier confirmation, and research chemical sourcing review.

Research use context

Use this page to review identity data, application tags, sourcing readiness, and RFQ context for heterocyclic building-block research, bioactivity screening workflows, research chemical sourcing.

Documentation needs

Request supplier-issued SDS/COA before handling, storage, shipment, or procurement decisions. Public page content is for research catalog reference and does not replace supplier-issued safety documentation.

Applications & Classification

Bioactivity Screening Heterocyclic Building Blocks Research Chemical SourcingResearch intermediateCustom synthesis building blockCustom synthesis and catalog availability reviewCOA, SDS, pricing, and fulfillment workflow

Biological target reference

ChEMBL reports experimental activity evidence for: Hepatocyte growth factor receptor (Homo sapiens) — 8 assays. These records describe research assays and do not establish therapeutic efficacy or clinical use.

Hepatocyte growth factor receptor

Homo sapiens · SINGLE PROTEIN · 8 qualifying assays · 8 documents · best pChEMBL 6.47

Experimental evidence source: ChEMBL

Safety & Handling

Safety and handling reference content is available through documentation requests.

For supplier-issued SDS, request documentation before handling, storage, shipment, or procurement decisions.

Preliminary Safety Reference

For supplier-issued SDS or COA, submit a documentation request.

Safety Reference / SDS Request

Synonyms & references

Names & Synonyms

(3R,4R)-3-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(1H-indol-3-yl)pyrrolidine-2,5-dione(3R,4R)-3-(5,6-Dihydro-4H-pyrrolo(3,2,1-ij)quinolin-1-yl)-4-(1H-indol-3-yl)pyrrolidine-2,5-dionetivantinibumc-Met Inhibitor ARQ 197(3R,4R)-3-(1-azatricyclo(6.3.1.0^(4,12))dodeca-2,4,6,8(12)-tetraen-3-yl)-4-(1H-indol-3-yl)pyrrolidine-2,5-dione

Show all synonyms

Tivantinib (ARQ 197)(rel)-Tivantinibrel-(3R,4R)-3-(5,6-Dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(1H-indol-3-yl)-2,5-pyrrolidinedione

External Identifiers

EC NUMBER: 805-160-2DSSTOX SUBSTANCE ID: DTXSID60920316CHEMBL ID: CHEMBL2103882CHEBI ID: CHEBI:91398UNII: PJ4H73IL17DRUGBANK ID: DB12200KEGG ID: D10173METABOLOMICS WORKBENCH ID: 153233NCI THESAURUS CODE: C62437PUBCHEM CID: 11494412WIKIDATA ID: Q17123902WIKIDATA ID: Q72443796

Literature & Patent References

DOI 10.1021/acs.jmedchem.4c02129Rational Design, Synthesis, and Biological Evaluation of Novel c-Met Degraders for Lung Cancer Therapy.PMID 39882685Rational Design, Synthesis, and Biological Evaluation of Novel c-Met Degraders for Lung Cancer Therapy.DOI 10.1016/j.ejmech.2024.116540Non-kinase off-target inhibitory activities of clinically-relevant kinase inhibitors.DOI 10.1021/acs.jmedchem.4c00077Rational Design of PARP1/c-Met Dual Inhibitors for Overcoming PARP1 Inhibitor Resistance Induced by c-Met Overexpression.PMID 38477575Rational Design of PARP1/c-Met Dual Inhibitors for Overcoming PARP1 Inhibitor Resistance Induced by c-Met Overexpression.PMID 38852338Non-kinase off-target inhibitory activities of clinically-relevant kinase inhibitors.DOI 10.1021/acs.jmedchem.3c00028Targeting MET: Discovery of Small Molecule Inhibitors as Non-Small Cell Lung Cancer Therapy.PMID 37262349Targeting MET: Discovery of Small Molecule Inhibitors as Non-Small Cell Lung Cancer Therapy.

Documentation & Compliance Facts

Compliance Facts

Signal word: Danger

Supplier SDS reference cue; confirm supplier documentation before use.

Hazard statements: H360, H373

Supplier SDS hazard code reference; confirm full text in supplier documentation.

Precautionary statements: P203, P260, P280, P318, P319, P405, P501

Supplier SDS precautionary code reference; confirm full text in supplier documentation.

Shipment review: Required

Documentation available by request

Certificate of Analysis (COA): By request

Supplier Safety Data Sheet (SDS): By request

Purity and pack size confirmation: By request

Availability and lead time review: Confirmed by RFQ

Shipment documentation review: By request

For supplier-issued documentation by request, use the RFQ actions on this page.Review preliminary safety reference

What happens after RFQ

1We review the CAS identity, quantity, and documentation request.
2We check sourcing options, supplier availability, COA/SDS, purity, pack size, and lead time.
3We review destination and shipment documentation needs when applicable.
4We follow up with a quotation or clarification request.

Text Reference Cues

Additional text reference cues are not available for this catalog entry.

Non-public references are shown as text only and do not imply equivalence, availability, or shared use.

Catalog navigation

Linked by recorded structural or research relationships, not interchangeable products. Check the exact CAS, specification and availability on the linked product page.

Procurement questions

What are the key identifiers for Tivantinib (CAS 1000873-98-2)?

Tivantinib is identified by CAS 1000873-98-2, with molecular formula C23H19N3O2, molecular weight 369.4, InChIKey UCEQXRCJXIVODC-PMACEKPBSA-N.

Does CAS 1000873-98-2 have reported biological target evidence?

ChEMBL contains qualifying experimental assay evidence associated with Hepatocyte growth factor receptor. These records do not establish therapeutic efficacy or clinical use.

Can I request a COA for CAS 1000873-98-2?

Yes. Submit an RFQ and specify COA requirements. Lot-specific COA depends on supplier confirmation.

Can I request supplier SDS for Tivantinib?

Yes. Supplier SDS can be requested through the RFQ workflow before handling, storage, shipment, or procurement decisions.

Is CAS 1000873-98-2 available for quotation?

Availability, pack size, lead time, and pricing are confirmed through RFQ.

Can MolGraph support bulk sourcing or custom synthesis review?

Submit the CAS number, quantity, purity requirement, and destination country for sourcing review.