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Home/Compounds/CAS 100643-71-8
Formula C19H19ClN2MW 310.8Research-use catalog entryCOA/SDS by request

Desloratadine

CAS Number: 100643-71-8

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Loading RDKit molecule structure...
InChIKey: JAUOIFJMECXRGI-UHFFFAOYSA-NC19H19ClN2 | MW 310.8

Chemical Absolute Identifiers

CAS Number

100643-71-8

PubChem CID

124087

Molecular Formula

C19H19ClN2

Molecular Weight

310.8 g/mol

Exact Mass

310.123676

InChIKey

JAUOIFJMECXRGI-UHFFFAOYSA-N

IUPAC Name

13-chloro-2-piperidin-4-ylidene-4-azatricyclo[9.4.0.03,8]pentadeca-1(11),3(8),4,6,12,14-hexaene

SMILES String

C1CC2=C(C=CC(=C2)Cl)C(=C3CCNCC3)C4=C1C=CC=N4

Physical Properties

No physical property values available.

Properties are provided as catalog reference data and may be confirmed through supplier documentation when required.

Catalog Facts

Structural features

Desloratadine (CAS 100643-71-8) is listed in the Advanced Chemicals portfolio, with molecular formula C19H19ClN2 and molecular weight 310. 80 g/mol.

Sourcing context

Catalog reference for RFQ preparation, supplier confirmation, and research chemical sourcing review.

Research use context

Intended for research building-block and synthetic chemistry workflows; structure-derived tags include nitrogen-containing heterocycle.

Documentation needs

COA/SDS status, availability, lead time, pack size, and shipment documentation can be confirmed during quotation.

Applications & Classification

Natural Product ResearchSynthetic ChemistryResearch intermediateCustom synthesis building blockResearch chemical sourcingCustom synthesis and catalog availability reviewCOA, SDS, pricing, and fulfillment workflow
Biological target reference

ChEMBL reports experimental activity evidence for: Histamine H1 receptor (Homo sapiens) — 13 assays; Histamine H2 receptor (Homo sapiens) — 3 assays; 5-hydroxytryptamine receptor 2A (Homo sapiens) — 4 assays; 5-hydroxytryptamine receptor 2C (Homo sapiens) — 2 assays; 5-hydroxytryptamine receptor 2B (Homo sapiens) — 5 assays. These records describe research assays and do not establish therapeutic efficacy or clinical use.

Histamine H1 receptor

Homo sapiens · SINGLE PROTEIN · 13 qualifying assays · 9 documents · best pChEMBL 9.19

Experimental evidence source: ChEMBL

Histamine H2 receptor

Homo sapiens · SINGLE PROTEIN · 3 qualifying assays · 2 documents · best pChEMBL 8.48

Experimental evidence source: ChEMBL

5-hydroxytryptamine receptor 2A

Homo sapiens · SINGLE PROTEIN · 4 qualifying assays · 2 documents · best pChEMBL 8.03

Experimental evidence source: ChEMBL

5-hydroxytryptamine receptor 2C

Homo sapiens · SINGLE PROTEIN · 2 qualifying assays · 2 documents · best pChEMBL 7.8

Experimental evidence source: ChEMBL

5-hydroxytryptamine receptor 2B

Homo sapiens · SINGLE PROTEIN · 5 qualifying assays · 2 documents · best pChEMBL 7.55

Experimental evidence source: ChEMBL

Safety & Handling

Safety and handling reference content is available through documentation requests.

For supplier-issued SDS, request documentation before handling, storage, shipment, or procurement decisions.

Preliminary Safety Reference

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Safety Reference / SDS Request

Names & Synonyms / External Identifiers

Chemical Name

Desloratadine

Names & Synonyms

ClarinexDescarboethoxyloratadineAeriusDesloratidineNeoclarityn
Show all synonyms
AzomyrDenosinAllexOpulisSch 341178-Chloro-11-piperidin-4-ylidene-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridineDesloratadine ActavisDasselta8-chloro-11-(piperidin-4-ylidene)-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridineDesloratadine teva5H-Benzo[5,6]cyclohepta[1,2-b]pyridine, 8-chloro-6,11-dihydro-11-(4-piperidinylidene)-Desloratadina8-Chloro-6,11-dihydro-11-(4-piperidinylidene)-5H-benzo(5,6)cyclohepta(1,2-b)pyridineDESLORATADINE RATIOPHARM
External Identifiers
EC NUMBER: 638-878-8DSSTOX SUBSTANCE ID: DTXSID1044196CHEMBL ID: CHEMBL1172CHEBI ID: CHEBI:291342UNII: FVF865388RDRUGBANK ID: DB00967HMDB ID: HMDB0015102KEGG ID: D03693METABOLOMICS WORKBENCH ID: 43222NCI THESAURUS CODE: C47474PHARMGKB ID: PA164776964RXCUI: 275635WIKIDATA ID: Q418060Sch-34117
Experimental Spectrum References
13C NMR Spectra
Literature & Patent References
DOI 10.1016/j.ejmech.2024.116197Discovery of the novel and potent histamine H1 receptor antagonists for treatment of allergic diseases.DOI 10.1016/j.isci.2024.108907Identification and evaluation of small-molecule inhibitors against the dNTPase SAMHD1 via a comprehensive screening funnelPMID 38318365Identification and evaluation of small-molecule inhibitors against the dNTPase SAMHD1 via a comprehensive screening funnelPMID 38368709Discovery of the novel and potent histamine H1 receptor antagonists for treatment of allergic diseases.DOI 10.1021/acs.jmedchem.3c01068Benzamidine Conjugation Converts Expelled Potential Active Agents into Antifungals against Drug-Resistant Fungi.DOI 10.1038/s41467-023-40064-9A preclinical secondary pharmacology resource illuminates target-adverse drug reaction associations of marketed drugs.PMID 37468498A preclinical secondary pharmacology resource illuminates target-adverse drug reaction associations of marketed drugs.PMID 37787457Benzamidine Conjugation Converts Expelled Potential Active Agents into Antifungals against Drug-Resistant Fungi.

Documentation & Compliance Facts

Compliance Facts

Shipment review: Required

Documentation available by request

Certificate of Analysis (COA): By request

Supplier Safety Data Sheet (SDS): By request

Purity and pack size confirmation: By request

Availability and lead time review: Confirmed by RFQ

Shipment documentation review: By request

For supplier-issued documentation by request, use the RFQ actions on this page.Review preliminary safety reference

What happens after RFQ

  1. 1We review the CAS identity, quantity, and documentation request.
  2. 2We check sourcing options, supplier availability, COA/SDS, purity, pack size, and lead time.
  3. 3We review destination and shipment documentation needs when applicable.
  4. 4We follow up with a quotation or clarification request.

Text Reference Cues

Additional text reference cues are not available for this catalog entry.

Non-public references are shown as text only and do not imply equivalence, availability, or shared use.

Catalog navigation

Related Catalog Entries

Other public CAS pages in this catalog. These links support navigation across additional intermediates and do not imply equivalence, availability, or shared use.

CAS 111974-69-7QuetiapineCAS 21829-25-4NifedipineCAS 181695-72-7ValdecoxibCAS 79794-75-5LoratadineCAS 1156-19-0TolazamideCAS 1002310-00-0Tert-butyl 1-(2-chloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)ethylcarbamateCAS 1005174-17-3(E)-3-(2-Propyl-6-(trifluoromethyl)pyridin-3-yl)acrylic acidCAS 1018125-49-92-(3-Cyclopropyl-6-ethyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl)acetic acidCAS 1018128-07-8Isopropyl 4-chloro-2-methylquinoline-6-carboxylateCAS 1018142-22-76-cyclopropyl-1-(2,2-difluoroethyl)-3-methyl-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid

RFQ questions for CAS 100643-71-8

What are the key identifiers for Desloratadine (CAS 100643-71-8)?

Desloratadine is identified by CAS 100643-71-8, with molecular formula C19H19ClN2, molecular weight 310.8, InChIKey JAUOIFJMECXRGI-UHFFFAOYSA-N.

Does CAS 100643-71-8 have reported biological target evidence?

ChEMBL contains qualifying experimental assay evidence associated with Histamine H1 receptor, Histamine H2 receptor, 5-hydroxytryptamine receptor 2A, 5-hydroxytryptamine receptor 2C, 5-hydroxytryptamine receptor 2B. These records do not establish therapeutic efficacy or clinical use.

Can I request a COA for CAS 100643-71-8?

Yes. Submit an RFQ and specify COA requirements. Lot-specific COA depends on supplier confirmation.

Can I request supplier SDS for Desloratadine?

Yes. Supplier SDS can be requested through the RFQ workflow before handling, storage, shipment, or procurement decisions.

Is CAS 100643-71-8 available for quotation?

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