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- Purity
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CAS Number: 1051375-16-6
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CAS Number
1051375-16-6
PubChem CID
54726191
Molecular Formula
C20H19F2N3O5
Molecular Weight
419.4 g/mol
Exact Mass
419.129277
InChIKey
RHWKPHLQXYSBKR-BMIGLBTASA-N
IUPAC Name
(3S,7R)-N-[(2,4-difluorophenyl)methyl]-11-hydroxy-7-methyl-9,12-dioxo-4-oxa-1,8-diazatricyclo[8.4.0.03,8]tetradeca-10,13-diene-13-carboxamide
SMILES String
C[C@@H]1CCO[C@H]2Cn3cc(C(=O)NCc4ccc(F)cc4F)c(=O)c(O)c3C(=O)N12
Melting Point
19–193 °C
pKa
8.2
Properties are provided as catalog reference data and may be confirmed through supplier documentation when required.
Structural features
Dolutegravir (CAS 1051375-16-6) is listed in the Pharmaceutical Intermediates portfolio, with molecular formula C20H19F2N3O5 and molecular weight 419. 40 g/mol.
Sourcing context
Catalog reference for RFQ preparation, supplier confirmation, and research chemical sourcing review.
Research use context
Intended for research-stage medicinal chemistry and intermediate synthesis workflows; structure-derived tags include nitrogen-containing heterocycle.
Documentation needs
COA/SDS status, availability, lead time, pack size, and shipment documentation can be confirmed during quotation.
ChEMBL reports experimental activity evidence for: Human immunodeficiency virus type 1 integrase (Human immunodeficiency virus 1) — 12 assays; Sigma intracellular receptor 2 (Rattus norvegicus) — 3 assays; Sigma non-opioid intracellular receptor 1 (Cavia porcellus) — 2 assays; Solute carrier family 22 member 2 (Homo sapiens) — 2 assays; Cytochrome P450 3A4 (Homo sapiens) — 6 assays. These records describe research assays and do not establish therapeutic efficacy or clinical use.
Human immunodeficiency virus type 1 integrase
Human immunodeficiency virus 1 · SINGLE PROTEIN · 12 qualifying assays · 9 documents · best pChEMBL 9.3
Experimental evidence source: ChEMBL
Sigma intracellular receptor 2
Rattus norvegicus · SINGLE PROTEIN · 3 qualifying assays · 3 documents · best pChEMBL 7.75
Experimental evidence source: ChEMBL
Sigma non-opioid intracellular receptor 1
Cavia porcellus · SINGLE PROTEIN · 2 qualifying assays · 2 documents · best pChEMBL 7.15
Experimental evidence source: ChEMBL
Solute carrier family 22 member 2
Homo sapiens · SINGLE PROTEIN · 2 qualifying assays · 1 documents · best pChEMBL 5.72
Experimental evidence source: ChEMBL
Cytochrome P450 3A4
Homo sapiens · SINGLE PROTEIN · 6 qualifying assays · 1 documents · best pChEMBL 4.48
Experimental evidence source: ChEMBL
Safety and handling reference content is available through documentation requests.
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Preliminary Safety Reference
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Safety Reference / SDS RequestCatalog navigation
Other public CAS pages in this catalog. These links support navigation across additional intermediates and do not imply equivalence, availability, or shared use.
Dolutegravir is identified by CAS 1051375-16-6, with molecular formula C20H19F2N3O5, molecular weight 419.4, InChIKey RHWKPHLQXYSBKR-BMIGLBTASA-N.
ChEMBL contains qualifying experimental assay evidence associated with Human immunodeficiency virus type 1 integrase, Sigma intracellular receptor 2, Sigma non-opioid intracellular receptor 1, Solute carrier family 22 member 2, Cytochrome P450 3A4. These records do not establish therapeutic efficacy or clinical use.
Yes. Submit an RFQ and specify COA requirements. Lot-specific COA depends on supplier confirmation.
Yes. Supplier SDS can be requested through the RFQ workflow before handling, storage, shipment, or procurement decisions.
Availability, pack size, lead time, and pricing are confirmed through RFQ.
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