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Home/Compounds/CAS 107724-20-9
Formula C24H30O6MW 414.5Research-use catalog entryCOA/SDS by request

Eplerenone

CAS Number: 107724-20-9

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Loading RDKit molecule structure...
InChIKey: JUKPWJGBANNWMW-VWBFHTRKSA-NC24H30O6 | MW 414.5

Chemical Absolute Identifiers

CAS Number

107724-20-9

PubChem CID

443872

Molecular Formula

C24H30O6

Molecular Weight

414.5 g/mol

Exact Mass

414.204239

InChIKey

JUKPWJGBANNWMW-VWBFHTRKSA-N

IUPAC Name

methyl (1R,2S,9R,10R,11S,14R,15S,17R)-2,15-dimethyl-5,5'-dioxospiro[18-oxapentacyclo[8.8.0.01,17.02,7.011,15]octadec-6-ene-14,2'-oxolane]-9-carboxylate

SMILES String

C[C@]12CCC(=O)C=C1C[C@H]([C@@H]3[C@]24[C@H](O4)C[C@]5([C@H]3CC[C@@]56CCC(=O)O6)C)C(=O)OC

Physical Properties

Water Solubility

9.03 × 10⁻³ g/L

Properties are provided as catalog reference data and may be confirmed through supplier documentation when required.

Catalog Facts

Structural features

Eplerenone (CAS 107724-20-9) is listed in the Pharmaceutical Intermediates portfolio, with molecular formula C24H30O6 and molecular weight 414. 50 g/mol.

Sourcing context

Catalog reference for RFQ preparation, supplier confirmation, and research chemical sourcing review.

Research use context

Intended for research-stage medicinal chemistry and intermediate synthesis workflows.

Documentation needs

COA/SDS status, availability, lead time, pack size, and shipment documentation can be confirmed during quotation.

Applications & Classification

Pharmaceutical Intermediate ResearchResearch intermediateCustom synthesis building blockPharmaceutical intermediate researchResearch chemical sourcingCustom synthesis and catalog availability reviewCOA, SDS, pricing, and fulfillment workflow
Biological target reference

ChEMBL reports experimental activity evidence for: Mineralocorticoid receptor (Rattus norvegicus) — 3 assays; Mineralocorticoid receptor (Homo sapiens) — 24 assays; Glucocorticoid receptor (Homo sapiens) — 9 assays; Androgen receptor (Homo sapiens) — 6 assays; Progesterone receptor (Homo sapiens) — 10 assays. These records describe research assays and do not establish therapeutic efficacy or clinical use.

Mineralocorticoid receptor

Rattus norvegicus · SINGLE PROTEIN · 3 qualifying assays · 2 documents · best pChEMBL 7.4

Experimental evidence source: ChEMBL

Mineralocorticoid receptor

Homo sapiens · SINGLE PROTEIN · 24 qualifying assays · 11 documents · best pChEMBL 7.2

Experimental evidence source: ChEMBL

Glucocorticoid receptor

Homo sapiens · SINGLE PROTEIN · 9 qualifying assays · 6 documents · best pChEMBL 5.5

Experimental evidence source: ChEMBL

Androgen receptor

Homo sapiens · SINGLE PROTEIN · 6 qualifying assays · 5 documents · best pChEMBL 4.77

Experimental evidence source: ChEMBL

Progesterone receptor

Homo sapiens · SINGLE PROTEIN · 10 qualifying assays · 6 documents · best pChEMBL 4.7

Experimental evidence source: ChEMBL

Safety & Handling

Safety and handling reference content is available through documentation requests.

For supplier-issued SDS, request documentation before handling, storage, shipment, or procurement decisions.

Preliminary Safety Reference

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Safety Reference / SDS Request

Names & Synonyms / External Identifiers

Chemical Name

Eplerenone

Names & Synonyms

Inspra(+)-EplerenoneEplerenona9,11alpha-Epoxy-17-hydroxy-3-oxo-17alpha-pregn-4-ene-7alpha,21-dicarboxylic acid, gamma-lactone, methyl estermethyl (1'R,2R,2'S,9'R,10'R,11'S,15'S,17'R)-2',15'-dimethyl-5,5'-dioxo-18'-oxaspiro[oxolane-2,14'-pentacyclo[8.8.0.0^{1,17}.0^{2,7}.0^{11,15}]octadecan]-6'-ene-9'-carboxylate
Show all synonyms
eplerenoneplerenonummethyl (1'R,2R,2'S,9'R,10'R,11'S,15'S,17'R)-2',15'-dimethyl-5,5'-dioxo-18'-oxaspiro(oxolane-2,14'-pentacyclo(8.8.0.0^(1,17).0^(2,7).0^(11,15))octadecan)-6'-ene-9'-carboxylate9,11alpha-Epoxy-7alpha-(methoxycarbonyl)-3-oxo-17alpha-pregn-4-ene-21,17-carbolactoneEpoxymexrenoneSelaraEplerenone [USAN]Inspra (TN)Cgp 30083HSDB 7522Eplerenone [USAN:INN:BAN]Eplerenone?Eplerenone CRSSC 6110Eplerenone (Standard)
External Identifiers
EC NUMBER: 600-850-8DSSTOX SUBSTANCE ID: DTXSID2046094CHEMBL ID: CHEMBL1095097CHEBI ID: CHEBI:31547UNII: 6995V82D0BDRUGBANK ID: DB00700HMDB ID: HMDB0014838KEGG ID: C12512KEGG ID: D01115METABOLOMICS WORKBENCH ID: 43011NCI THESAURUS CODE: C47513PHARMGKB ID: PA164749044RXCUI: 298869WIKIDATA ID: Q423804
Literature & Patent References
DOI 10.6019/CHEMBL5724709EUbOPEN Chemogenomics Library - IncuCyteDOI 10.6019/CHEMBL5724796Tm Shift (DSF) assay results for EUbOPEN Chemogenomics LibraryDOI 10.1038/s41467-023-40064-9A preclinical secondary pharmacology resource illuminates target-adverse drug reaction associations of marketed drugs.PMID 37468498A preclinical secondary pharmacology resource illuminates target-adverse drug reaction associations of marketed drugs.DOI 10.1021/acs.jmedchem.2c00402Discovery of Apararenone (MT-3995) as a Highly Selective, Potent, and Novel Nonsteroidal Mineralocorticoid Receptor Antagonist.PMID 35652647Discovery of Apararenone (MT-3995) as a Highly Selective, Potent, and Novel Nonsteroidal Mineralocorticoid Receptor Antagonist.DOI 10.6019/CHEMBL4808148HDAC6 screening dataset using tau-based substrate in an enzymatic assay yields selective inhibitors and activatorsDOI 10.1101/2020.04.21.054387Identification of potential treatments for COVID-19 through artificial intelligence-enabled phenomic analysis of human cells infected with SARS-CoV-2

Documentation & Compliance Facts

Compliance Facts

Shipment review: Required

Documentation available by request

Certificate of Analysis (COA): By request

Supplier Safety Data Sheet (SDS): By request

Purity and pack size confirmation: By request

Availability and lead time review: Confirmed by RFQ

Shipment documentation review: By request

For supplier-issued documentation by request, use the RFQ actions on this page.Review preliminary safety reference

What happens after RFQ

  1. 1We review the CAS identity, quantity, and documentation request.
  2. 2We check sourcing options, supplier availability, COA/SDS, purity, pack size, and lead time.
  3. 3We review destination and shipment documentation needs when applicable.
  4. 4We follow up with a quotation or clarification request.

Text Reference Cues

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Non-public related references

methyl (7R,8S,9S,10R,11R,13S,14S,17R)-11-hydroxy-10,13-dimethyl-3,5'-dioxospiro(2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta(a)phenanthrene-17,2'-oxolane)-7-carboxylateCAS 192704-56-6
delta9,11-EplerenoneCAS 95716-70-4
Delta 9,11-canrenoneCAS 95716-71-5

Non-public references are shown as text only and do not imply equivalence, availability, or shared use.

Catalog navigation

Related Catalog Entries

Other public CAS pages in this catalog. These links support navigation across additional intermediates and do not imply equivalence, availability, or shared use.

CAS 192704-56-6methyl (7R,8S,9S,10R,11R,13S,14S,17R)-11-hydroxy-10,13-dimethyl-3,5'-dioxospiro(2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta(a)phenanthrene-17,2'-oxolane)-7-carboxylateCAS 95716-70-4delta9,11-EplerenoneCAS 181695-72-7ValdecoxibCAS 139481-59-7CandesartanCAS 21829-25-4NifedipineCAS 128517-07-7RomidepsinCAS 27589-33-9AzosemideCAS 1002310-00-0Tert-butyl 1-(2-chloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)ethylcarbamateCAS 1005174-17-3(E)-3-(2-Propyl-6-(trifluoromethyl)pyridin-3-yl)acrylic acidCAS 1018125-49-92-(3-Cyclopropyl-6-ethyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl)acetic acid

RFQ questions for CAS 107724-20-9

What are the key identifiers for Eplerenone (CAS 107724-20-9)?

Eplerenone is identified by CAS 107724-20-9, with molecular formula C24H30O6, molecular weight 414.5, InChIKey JUKPWJGBANNWMW-VWBFHTRKSA-N.

Does CAS 107724-20-9 have reported biological target evidence?

ChEMBL contains qualifying experimental assay evidence associated with Mineralocorticoid receptor, Mineralocorticoid receptor, Glucocorticoid receptor, Androgen receptor, Progesterone receptor. These records do not establish therapeutic efficacy or clinical use.

Can I request a COA for CAS 107724-20-9?

Yes. Submit an RFQ and specify COA requirements. Lot-specific COA depends on supplier confirmation.

Can I request supplier SDS for Eplerenone?

Yes. Supplier SDS can be requested through the RFQ workflow before handling, storage, shipment, or procurement decisions.

Is CAS 107724-20-9 available for quotation?

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