MolGraphChemical Intelligence
Active Chemical RecordCatalog PreviewCatalog ready

[4,5,6,7-Tetrabromo-2-(Dimethylamino)-1h-Benzimidazol-1-Yl]acetic Acid

CAS 1085822-09-8Formula C11H9Br4N3O2MW 534.82PubChem 46943415

[4,5,6,7-Tetrabromo-2-(Dimethylamino)-1h-Benzimidazol-1-Yl]acetic Acid, also known as TMCB or Casein Kinase II Inhibitor VI, is a research chemical primarily recognized for its inhibitory activity against Casein Kinase II (CK2).

Loading RDKit molecule structure...
InChIKey: PHAOTASRLQMKBE-UHFFFAOYSA-NC11H9Br4N3O2 | MW 534.82

Chemical Identity

Molecular Formula

C11H9Br4N3O2

Molecular Weight

534.82 g/mol

Exact Mass

534.73873

PubChem CID

46943415

IUPAC Name

2-[4,5,6,7-tetrabromo-2-(dimethylamino)benzimidazol-1-yl]acetic acid

SMILES String

CN(C)c1nc2c(Br)c(Br)c(Br)c(Br)c2n1CC(=O)O

Names & Synonyms

TMCBCK2/ERK8-IN-12-(4,5,6,7-Tetrabromo-2-(dimethylamino)-1H-benzo[d]imidazol-1-yl)acetic acid4,5,6,7-Tetrabromo-2-(dimethylamino)-1H-benzimidazole-1-acetic acidcompound 2c [PMID: 22115617]
Show all synonyms
GTPL8140Casein Kinase II Inhibitor VI, TMCBK66T10827Q27076513[4,5,6,7-Tetrabromo-2-(dimethylamino)-1H-1,3-benzimidazol-1-yl]acetic acid
External Identifiers
CHEMBL1233807orb1710039SCHEMBL1759230DTXSID50677589GLXC-06309FLB10589KTB82209BDBM50359846AKOS024457742AT13627NCGC00387111-01DA-58623MS-29888HY-135906CS-0116229

Catalog Overview

This compound, with CAS number 1085822-09-8, is a complex organic molecule featuring a tetrabrominated benzimidazole core, a dimethylamino group, and an acetic acid moiety. It is widely studied in biochemical research as a potent and selective inhibitor of Casein Kinase II (CK2), a ubiquitous serine/threonine protein kinase involved in various cellular processes including cell growth, proliferation, and survival. Its mechanism of action involves interfering with CK2 activity, making it a valuable tool for investigating CK2-dependent signaling pathways and their roles in health and disease.

Use Context

  • Research chemical sourcing
  • Custom synthesis and catalog availability review
  • COA, SDS, pricing, and fulfillment workflow

Physical Data

Estimated

Estimated / predicted physical property values for catalog reference.

Appearance

White to off-white crystalline powder

Physical State

Solid

Melting Point

205.0 °C

Density

1.9 g/cm³

Water Solubility

Slightly soluble to insoluble

Flash Point

250.0 °C

Applications / Classifications

Research intermediateCustom synthesis building block

Biological Target Reference

No verified biological target assignment. This compound is listed primarily as a research or synthetic intermediate.

Preliminary Safety-Style Reference

Preliminary

Preliminary safety-style information for reference only. Not a supplier SDS.

Handling and Storage
  • Handle all research chemicals, including [4,5,6,7-Tetrabromo-2-(Dimethylamino)-1h-Benzimidazol-1-Yl]acetic Acid, with appropriate personal protective equipment (PPE) such as gloves, eye protection, and a lab coat. Work in a well-ventilated area or fume hood to minimize exposure. Avoid inhalation, ingestion, and skin contact. Refer to the Safety Data Sheet (SDS) for detailed hazard information and emergency procedures. Store in a cool, dry place away from incompatible materials.

Related Products / Graph Discovery

Related products, derivatives, keywords, and application cues for catalog discovery.

Related products and analog discovery will be available as catalog graph data is expanded.