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Home/Compounds/CAS 1140909-48-3
Formula C32H30FN3O10MW 635.6Research-use catalog entryCOA/SDS by request

Cabozantinib S-malate

CAS Number: 1140909-48-3

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Loading RDKit molecule structure...
InChIKey: HFCFMRYTXDINDK-WNQIDUERSA-NC32H30FN3O10 | MW 635.6

Chemical Absolute Identifiers

CAS Number

1140909-48-3

PubChem CID

25102846

Molecular Formula

C32H30FN3O10

Molecular Weight

635.6 g/mol

Exact Mass

635.191522

InChIKey

HFCFMRYTXDINDK-WNQIDUERSA-N

IUPAC Name

1-N-[4-(6,7-dimethoxyquinolin-4-yl)oxyphenyl]-1-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide;(2S)-2-hydroxybutanedioic acid

SMILES String

COc1cc2nccc(Oc3ccc(NC(=O)C4(C(=O)Nc5ccc(F)cc5)CC4)cc3)c2cc1OC.O=C(O)C[C@H](O)C(=O)O

Physical Properties

No physical property values available.

Properties are provided as catalog reference data and may be confirmed through supplier documentation when required.

Catalog Facts

Structural features

Cabozantinib S-malate (CAS 1140909-48-3) is listed in the Pharmaceutical Intermediates portfolio, with molecular formula C32H30FN3O10 and molecular weight 635. 60 g/mol.

Sourcing context

Catalog reference for RFQ preparation, supplier confirmation, and research chemical sourcing review.

Research use context

Intended for research-stage medicinal chemistry and intermediate synthesis workflows; structure-derived tags include nitrogen-containing heterocycle.

Documentation needs

COA/SDS status, availability, lead time, pack size, and shipment documentation can be confirmed during quotation.

Applications & Classification

Pharmaceutical Intermediate ResearchResearch intermediateCustom synthesis building blockPharmaceutical intermediate researchResearch chemical sourcingCustom synthesis and catalog availability reviewCOA, SDS, pricing, and fulfillment workflow
Biological target reference

ChEMBL reports experimental activity evidence for: Hepatocyte growth factor receptor (Homo sapiens) — 2 assays. These records describe research assays and do not establish therapeutic efficacy or clinical use.

Hepatocyte growth factor receptor

Homo sapiens · SINGLE PROTEIN · 2 qualifying assays · 1 documents · best pChEMBL 8.49

Experimental evidence source: ChEMBL

Safety & Handling

Safety and handling reference content is available through documentation requests.

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Preliminary Safety Reference

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Names & Synonyms / External Identifiers

Chemical Name

Cabozantinib S-malate

Names & Synonyms

Cabozantinib malatecabozantinib (S)-malateCabometyxXL184Cabozantinib malate (XL184)
Show all synonyms
Cabozantinib (S-malate)Cabozantinib L-Malate SaltCabozantinib s-malate [USAN]N-(4-((6,7-dimethoxyquinolin-4-yl)oxy)phenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide (S)-2-hydroxysuccinateCabometyx (TN)Cometriq (TN)Cabozantinib malate (JAN)Cabozantinib s-malate (USAN)CABOZANTINIB MALATE [JAN]cabozantinib L-malateRESNIBENXL-184 malateCabozantinib S-malate?Cabozantinib S-Malate saltXL184(Cabozantinib malate)
External Identifiers
EC NUMBER: 691-711-0DSSTOX SUBSTANCE ID: DTXSID60915949CHEMBL ID: CHEMBL2103868CHEBI ID: CHEBI:72319UNII: DR7ST46X58KEGG ID: D10095NCI THESAURUS CODE: C97938RXCUI: 1363267WIKIDATA ID: Q27139901
Literature & Patent References
DOI 10.1016/j.bmc.2023.117561Discovery of pyrazolo[3,4-d]pyrimidines as novel mitogen-activated protein kinase kinase 3 (MKK3) inhibitors.PMID 38157838Discovery of pyrazolo[3,4-d]pyrimidines as novel mitogen-activated protein kinase kinase 3 (MKK3) inhibitors.DOI 10.1016/j.ejmech.2018.09.050Exploration of novel pyrrolo[2,1-f][1,2,4]triazine derivatives with improved anticancer efficacy as dual inhibitors of c-Met/VEGFR-2.PMID 30248654Exploration of novel pyrrolo[2,1-f][1,2,4]triazine derivatives with improved anticancer efficacy as dual inhibitors of c-Met/VEGFR-2.DOI 10.1016/j.bmc.2016.03.061Design, synthesis and biological evaluation of 4-aminopyrimidine-5-cabaldehyde oximes as dual inhibitors of c-Met and VEGFR-2.PMID 27068889Design, synthesis and biological evaluation of 4-aminopyrimidine-5-cabaldehyde oximes as dual inhibitors of c-Met and VEGFR-2.

Documentation & Compliance Facts

Compliance Facts

Shipment review: Required

Documentation available by request

Certificate of Analysis (COA): By request

Supplier Safety Data Sheet (SDS): By request

Purity and pack size confirmation: By request

Availability and lead time review: Confirmed by RFQ

Shipment documentation review: By request

For supplier-issued documentation by request, use the RFQ actions on this page.Review preliminary safety reference

What happens after RFQ

  1. 1We review the CAS identity, quantity, and documentation request.
  2. 2We check sourcing options, supplier availability, COA/SDS, purity, pack size, and lead time.
  3. 3We review destination and shipment documentation needs when applicable.
  4. 4We follow up with a quotation or clarification request.

Text Reference Cues

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Non-public related references

1-(((4-((6,7-Dimethoxy-4-quinolinyl)oxy)phenyl)amino)carbonyl)cyclopropanecarboxylic acidCAS 849217-77-2
4-[(6,7-Dimethoxyquinolin-4-yl)oxy]anilineCAS 190728-25-7
6,7-Dimethoxy-4-(4-nitrophenoxy)quinolineCAS 190728-24-6
1-[(4-Fluorophenyl)carbamoyl]cyclopropanecarboxylic AcidCAS 849217-48-7
N-(4-Fluorophenyl)-N'-(4-hydroxyphenyl)cyclopropane-1,1-dicarboxamideCAS 849217-60-3

Non-public references are shown as text only and do not imply equivalence, availability, or shared use.

Catalog navigation

Related Catalog Entries

Other public CAS pages in this catalog. These links support navigation across additional intermediates and do not imply equivalence, availability, or shared use.

CAS 849217-77-21-(((4-((6,7-Dimethoxy-4-quinolinyl)oxy)phenyl)amino)carbonyl)cyclopropanecarboxylic acidCAS 190728-25-74-[(6,7-Dimethoxyquinolin-4-yl)oxy]anilineCAS 190728-24-66,7-Dimethoxy-4-(4-nitrophenoxy)quinolineCAS 97-67-6L-Malic AcidCAS 1002310-00-0Tert-butyl 1-(2-chloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)ethylcarbamateCAS 1005174-17-3(E)-3-(2-Propyl-6-(trifluoromethyl)pyridin-3-yl)acrylic acidCAS 1018125-49-92-(3-Cyclopropyl-6-ethyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl)acetic acidCAS 1018128-07-8Isopropyl 4-chloro-2-methylquinoline-6-carboxylateCAS 1018142-22-76-cyclopropyl-1-(2,2-difluoroethyl)-3-methyl-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acidCAS 1018144-00-72-(3-Cyclopropyl-6-isopropyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl)acetic acid

RFQ questions for CAS 1140909-48-3

What are the key identifiers for Cabozantinib S-malate (CAS 1140909-48-3)?

Cabozantinib S-malate is identified by CAS 1140909-48-3, with molecular formula C32H30FN3O10, molecular weight 635.6, InChIKey HFCFMRYTXDINDK-WNQIDUERSA-N.

Does CAS 1140909-48-3 have reported biological target evidence?

ChEMBL contains qualifying experimental assay evidence associated with Hepatocyte growth factor receptor. These records do not establish therapeutic efficacy or clinical use.

Can I request a COA for CAS 1140909-48-3?

Yes. Submit an RFQ and specify COA requirements. Lot-specific COA depends on supplier confirmation.

Can I request supplier SDS for Cabozantinib S-malate?

Yes. Supplier SDS can be requested through the RFQ workflow before handling, storage, shipment, or procurement decisions.

Is CAS 1140909-48-3 available for quotation?

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