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Home/Compounds/CAS 1142363-52-7
Formula C27H35N5O2MW 461.6Research-use catalog entryCOA/SDS by request

Edicotinib

CAS Number: 1142363-52-7

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Loading RDKit molecule structure...
InChIKey: BNVPFDRNGHMRJS-UHFFFAOYSA-NC27H35N5O2 | MW 461.6

Chemical Absolute Identifiers

CAS Number

1142363-52-7

PubChem CID

25230468

Molecular Formula

C27H35N5O2

Molecular Weight

461.6 g/mol

Exact Mass

461.279075

InChIKey

BNVPFDRNGHMRJS-UHFFFAOYSA-N

IUPAC Name

5-cyano-N-[2-(4,4-dimethylcyclohexen-1-yl)-6-(2,2,6,6-tetramethyloxan-4-yl)-3-pyridinyl]-1H-imidazole-2-carboxamide

SMILES String

CC1(C)CC=C(c2nc(C3CC(C)(C)OC(C)(C)C3)ccc2NC(=O)c2ncc(C#N)[nH]2)CC1

Physical Properties

No physical property values available.

Properties are provided as catalog reference data and may be confirmed through supplier documentation when required.

Catalog Facts

Structural features

Edicotinib (CAS 1142363-52-7) is listed in the Advanced Chemicals portfolio, with molecular formula C27H35N5O2 and molecular weight 461. 60 g/mol.

Sourcing context

Catalog reference for RFQ preparation, supplier confirmation, and research chemical sourcing review.

Research use context

Intended for research building-block and synthetic chemistry workflows; structure-derived tags include nitrogen-containing heterocycle.

Documentation needs

COA/SDS status, availability, lead time, pack size, and shipment documentation can be confirmed during quotation.

Applications & Classification

Heterocyclic Building BlocksSynthetic ChemistryResearch intermediateCustom synthesis building blockResearch chemical sourcingCustom synthesis and catalog availability reviewCOA, SDS, pricing, and fulfillment workflow
Biological target reference

ChEMBL reports experimental activity evidence for: Macrophage colony-stimulating factor 1 receptor (Mus musculus) — 5 assays; Macrophage colony-stimulating factor 1 receptor (Homo sapiens) — 11 assays; Mast/stem cell growth factor receptor Kit (Homo sapiens) — 2 assays; Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens) — 2 assays. These records describe research assays and do not establish therapeutic efficacy or clinical use.

Macrophage colony-stimulating factor 1 receptor

Mus musculus · SINGLE PROTEIN · 5 qualifying assays · 3 documents · best pChEMBL 8.54

Experimental evidence source: ChEMBL

Macrophage colony-stimulating factor 1 receptor

Homo sapiens · SINGLE PROTEIN · 11 qualifying assays · 7 documents · best pChEMBL 8.49

Experimental evidence source: ChEMBL

Mast/stem cell growth factor receptor Kit

Homo sapiens · SINGLE PROTEIN · 2 qualifying assays · 2 documents · best pChEMBL 7.7

Experimental evidence source: ChEMBL

Receptor-type tyrosine-protein kinase FLT3

Homo sapiens · SINGLE PROTEIN · 2 qualifying assays · 2 documents · best pChEMBL 6.72

Experimental evidence source: ChEMBL

Safety & Handling

Safety and handling reference content is available through documentation requests.

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Preliminary Safety Reference

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Names & Synonyms / External Identifiers

Chemical Name

Edicotinib

Names & Synonyms

4-Cyano-1H-imidazole-2-carboxylic acid N-(2-(4,4-dimethylcyclohex-1-enyl)-6-(2,2,6,6-tetramethyltetrahydropyran-4-yl)pyridin-3-yl)amide1H-Imidazole-2-carboxamide, 5-cyano-N-(2-(4,4-dimethyl-1-cyclohexen-1-yl)-6-(tetrahydro-2,2,6,6-tetramethyl-2H-pyran-4-yl)-3-pyridinyl)-4-Cyano-N-(2-(4,4-dimethylcyclohex-1-en-1-yl)-6-(2,2,6,6-tetramethyl-tetrahydro-2H-pyran-4-yl)pyridin-3-yl)-1H-imidazole-2-carboxamide4-cyano-N-[2-(4,4-dimethylcyclohex-1-en-1-yl)-6-(2,2,6,6-tetramethyloxan-4-yl)pyridin-3-yl]-1H-imidazole-2-carboxamideedicotinibum
Show all synonyms
4-cyano-N-(2-(4,4-dimethylcyclohex-1-en-1-yl)-6-(2,2,6,6-tetramethyloxan-4-yl)pyridin-3-yl)-1H-imidazole-2-carboxamide5-cyano-N-(2-(4,4-dimethylcyclohex-1-en-1-yl)-6-(2,2,6,6-tetramethyloxan-4-yl)pyridin-3-yl)-1H-imidazole-2-carboxamideEdicotinib [USAN]5-Cyano-N-(2-(4,4-dimethylcyclohex-1-en-1-yl)-6-(2,2,6,6-tetramethyltetrahydro-2H-pyran-4-yl)pyridin-3-yl)-1H-imidazole-2-carboxamide5-cyano-N-[2-(4,4-dimethylcyclohexen-1-yl)-6-(2,2,6,6-tetramethyloxan-4-yl)pyridin-3-yl]-1H-imidazole-2-carboxamideEdicotinib (USAN)US8497376, 15EDICOTINIB [INN]EDICOTINIB [WHO-DD]US10071991, Compound (P)4-cyano-N-(2-(4,4-dimethylcyclohex-1-en-1-yl)-6-(2,2,6,6-tetramethyltetrahydro-2H-pyran-4-yl)pyridin-3-yl)-1H-imidazole-2-carboxamide4-cyano-1h-imidazole-2-carboxylic acid[2-(4,4-dimethyl-cyclohex-1-enyl)-6-(2,2,6,6-tetramethyl-tetrahydro-pyran-4-yl)-pyridin-3-yl]-amide4-cyano-N-(2-(4,4-dimethylcyclohex-1-en-1-yl)-6-(2,2,6,6-tetramethyltetrahydro-2H-pyran-4-yl)pyridin-3-yl)- 1H-imidazole-2-carboxamide5-Cyano-N-[2-(4,4-dimethyl-1-cyclohexen-1-yl)-6-(2,2,6,6-tetramethyltetrahydro-2H-pyran-4-yl)-3-pyridinyl]-1H-imidazole-2-carboxamide
External Identifiers
CHEMBL ID: CHEMBL3674570UNII: 3NU609VYNFDRUGBANK ID: DB12504KEGG ID: D11378METABOLOMICS WORKBENCH ID: 153480NCI THESAURUS CODE: C101519WIKIDATA ID: Q27893923EdicotinibJNJ-40346527
Literature & Patent References
DOI 10.1016/j.ejmech.2024.116253Discovery of N-(5-amido-2-methylphenyl)-5-methylisoxazole-3-carboxamide as dual CSF-1R/c-Kit Inhibitors with improved stability and BBB permeability.PMID 38401188Discovery of N-(5-amido-2-methylphenyl)-5-methylisoxazole-3-carboxamide as dual CSF-1R/c-Kit Inhibitors with improved stability and BBB permeability.DOI 10.1016/j.ejmech.2022.114884CSF1R inhibitors are emerging immunotherapeutic drugs for cancer treatment.DOI 10.1016/j.ejmech.2023.115796The latest perspectives of small molecules FMS kinase inhibitors.DOI 10.6019/EOS300108ECBD screening data for assay EOS300108PMID 36335744CSF1R inhibitors are emerging immunotherapeutic drugs for cancer treatment.PMID 37708796The latest perspectives of small molecules FMS kinase inhibitors.DOI 10.1016/j.ejmech.2021.113298Discovery of potent colony-stimulating factor 1 receptor inhibitors by replacement of hinge-binder moieties.

Documentation & Compliance Facts

Compliance Facts

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Documentation available by request

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Text Reference Cues

Additional text reference cues are not available for this catalog entry.

Non-public references are shown as text only and do not imply equivalence, availability, or shared use.

Catalog navigation

Related Catalog Entries

Other public CAS pages in this catalog. These links support navigation across additional intermediates and do not imply equivalence, availability, or shared use.

CAS 1170613-55-4A-967079CAS 120685-11-2MidostaurinCAS 146535-11-76,7-Dimethoxy-3-phenylquinoxalineCAS 1002310-00-0Tert-butyl 1-(2-chloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)ethylcarbamateCAS 1005174-17-3(E)-3-(2-Propyl-6-(trifluoromethyl)pyridin-3-yl)acrylic acidCAS 1018125-49-92-(3-Cyclopropyl-6-ethyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl)acetic acidCAS 1018128-07-8Isopropyl 4-chloro-2-methylquinoline-6-carboxylateCAS 1018142-22-76-cyclopropyl-1-(2,2-difluoroethyl)-3-methyl-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acidCAS 1018144-00-72-(3-Cyclopropyl-6-isopropyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl)acetic acid

RFQ questions for CAS 1142363-52-7

What are the key identifiers for Edicotinib (CAS 1142363-52-7)?

Edicotinib is identified by CAS 1142363-52-7, with molecular formula C27H35N5O2, molecular weight 461.6, InChIKey BNVPFDRNGHMRJS-UHFFFAOYSA-N.

Does CAS 1142363-52-7 have reported biological target evidence?

ChEMBL contains qualifying experimental assay evidence associated with Macrophage colony-stimulating factor 1 receptor, Macrophage colony-stimulating factor 1 receptor, Mast/stem cell growth factor receptor Kit, Receptor-type tyrosine-protein kinase FLT3. These records do not establish therapeutic efficacy or clinical use.

Can I request a COA for CAS 1142363-52-7?

Yes. Submit an RFQ and specify COA requirements. Lot-specific COA depends on supplier confirmation.

Can I request supplier SDS for Edicotinib?

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