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Home/Compounds/CAS 1174043-16-3
Formula C22H22FN3O3MW 395.4Research-use catalog entryCOA/SDS by request

Azd-2461

CAS Number: 1174043-16-3

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Loading RDKit molecule structure...
InChIKey: HYNBNUYQTQIHJK-UHFFFAOYSA-NC22H22FN3O3 | MW 395.4

Chemical Absolute Identifiers

CAS Number

1174043-16-3

PubChem CID

44199317

Molecular Formula

C22H22FN3O3

Molecular Weight

395.4 g/mol

Exact Mass

395.16452

InChIKey

HYNBNUYQTQIHJK-UHFFFAOYSA-N

IUPAC Name

4-[[4-fluoro-3-(4-methoxypiperidine-1-carbonyl)phenyl]methyl]-2H-phthalazin-1-one

SMILES String

COC1CCN(C(=O)c2cc(Cc3n[nH]c(=O)c4ccccc34)ccc2F)CC1

Physical Properties

No physical property values available.

Properties are provided as catalog reference data and may be confirmed through supplier documentation when required.

Catalog Facts

Structural features

Azd-2461 (CAS 1174043-16-3) is listed in the Advanced Chemicals portfolio, with molecular formula C22H22FN3O3 and molecular weight 395. 40 g/mol.

Sourcing context

Catalog reference for RFQ preparation, supplier confirmation, and research chemical sourcing review.

Research use context

Intended for research building-block and synthetic chemistry workflows; structure-derived tags include nitrogen-containing heterocycle.

Documentation needs

COA/SDS status, availability, lead time, pack size, and shipment documentation can be confirmed during quotation.

Applications & Classification

Heterocyclic Building BlocksSynthetic ChemistryResearch intermediateCustom synthesis building blockResearch chemical sourcingCustom synthesis and catalog availability reviewCOA, SDS, pricing, and fulfillment workflow
Biological target reference

ChEMBL reports experimental activity evidence for: Poly [ADP-ribose] polymerase 1 (Homo sapiens) — 4 assays; Protein deacetylase HDAC6 (Homo sapiens) — 2 assays. These records describe research assays and do not establish therapeutic efficacy or clinical use.

Poly [ADP-ribose] polymerase 1

Homo sapiens · SINGLE PROTEIN · 4 qualifying assays · 4 documents · best pChEMBL 8.77

Experimental evidence source: ChEMBL

Protein deacetylase HDAC6

Homo sapiens · SINGLE PROTEIN · 2 qualifying assays · 1 documents

Experimental evidence source: ChEMBL

Safety & Handling

Safety and handling reference content is available through documentation requests.

For supplier-issued SDS, request documentation before handling, storage, shipment, or procurement decisions.

Preliminary Safety Reference

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Safety Reference / SDS Request

Names & Synonyms / External Identifiers

Chemical Name

Azd-2461

Names & Synonyms

AZD 24614-[4-Fluoro-3-[(4-methoxypiperidin-1-yl)carbonyl]benzyl]phthalazin-1(2H)-one4-(4-Fluoro-3-((4-methoxypiperidin-1-yl)carbonyl)benzyl)phthalazin-1(2H)-one1(2H)-Phthalazinone, 4-((4-fluoro-3-((4-methoxy-1-piperidinyl)carbonyl)phenyl)methyl)-1(2H)-Phthalazinone, 4-[[4-fluoro-3-[(4-methoxy-1-piperidinyl)carbonyl]phenyl]methyl]-
Show all synonyms
4-((4-fluoro-3-(4-methoxypiperidine-1-carbonyl)phenyl)methyl)-2H-phthalazin-1-one4-(4-fluoro-3-(4-methoxypiperidine-1-carbonyl)benzyl)phthalazin-1(2H)-oneAZD 2461 [WHO-DD]AZD2461?s70294-{[4-fluoro-3-(4-methoxypiperidine-1-carbonyl)phenyl]methyl}-1,2-dihydrophthalazin-1-oneAZD2461, >=98% (HPLC)A96124-{[4-Fluoro-3-(4-methoxypiperidine-1-carbonyl)phenyl]methyl}phthalazin-1(2H)-one
External Identifiers
EC NUMBER: 682-440-9DSSTOX SUBSTANCE ID: DTXSID00657831CHEMBL ID: CHEMBL4098253UNII: 3K288XF5XJWIKIDATA ID: Q27074723
Literature & Patent References
DOI 10.1039/d3md00751kDesign and synthesis of novel chloropyridazine hybrids as promising anticancer agents acting by apoptosis induction and PARP-1 inhibition through a molecular hybridization strategy.DOI 10.6019/CHEMBL5724796Tm Shift (DSF) assay results for EUbOPEN Chemogenomics LibraryPMID 38516606Design and synthesis of novel chloropyridazine hybrids as promising anticancer agents acting by apoptosis induction and PARP-1 inhibition through a molecular hybridization strategy.DOI 10.1016/j.ejmech.2020.112946Pyridazine as a privileged structure: An updated review on anticancer activity of pyridazine containing bioactive molecules.DOI 10.1021/acs.jmedchem.1c00567Discovery of First-in-Class Dual PARP and EZH2 Inhibitors for Triple-Negative Breast Cancer with Wild-Type BRCA.DOI 10.1186/s13148-021-01037-1Synergistic effects of type I PRMT and PARP inhibitors against non-small cell lung cancer cells.DOI 10.6019/CHEMBL4808148HDAC6 screening dataset using tau-based substrate in an enzymatic assay yields selective inhibitors and activatorsPMID 33129590Pyridazine as a privileged structure: An updated review on anticancer activity of pyridazine containing bioactive molecules.

Documentation & Compliance Facts

Compliance Facts

Shipment review: Required

Documentation available by request

Certificate of Analysis (COA): By request

Supplier Safety Data Sheet (SDS): By request

Purity and pack size confirmation: By request

Availability and lead time review: Confirmed by RFQ

Shipment documentation review: By request

For supplier-issued documentation by request, use the RFQ actions on this page.Review preliminary safety reference

What happens after RFQ

  1. 1We review the CAS identity, quantity, and documentation request.
  2. 2We check sourcing options, supplier availability, COA/SDS, purity, pack size, and lead time.
  3. 3We review destination and shipment documentation needs when applicable.
  4. 4We follow up with a quotation or clarification request.

Text Reference Cues

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Non-public related references

4-((4-Fluoro-3-(piperazine-1-carbonyl)phenyl)methyl)-1,2-dihydrophthalazin-1-oneCAS 763111-47-3
Tert-butyl 4-{2-fluoro-5-[(4-oxo-3,4-dihydrophthalazin-1-yl)methyl]benzoyl}piperazine-1-carboxylateCAS 763114-04-1
2-Fluoro-5-[(4-oxo-3,4-dihydrophthalazin-1-yl)methyl]benzoic acidCAS 763114-26-7
2-Fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)methyl)benzamideCAS 1956340-97-8
2-Fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)methyl)benzohydrazideCAS 1956383-44-0

Non-public references are shown as text only and do not imply equivalence, availability, or shared use.

Catalog navigation

Related Catalog Entries

Other public CAS pages in this catalog. These links support navigation across additional intermediates and do not imply equivalence, availability, or shared use.

CAS 763111-47-34-((4-Fluoro-3-(piperazine-1-carbonyl)phenyl)methyl)-1,2-dihydrophthalazin-1-oneCAS 763114-04-1Tert-butyl 4-{2-fluoro-5-[(4-oxo-3,4-dihydrophthalazin-1-yl)methyl]benzoyl}piperazine-1-carboxylateCAS 763114-26-72-Fluoro-5-[(4-oxo-3,4-dihydrophthalazin-1-yl)methyl]benzoic acidCAS 1956340-97-82-Fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)methyl)benzamideCAS 1956383-44-02-Fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)methyl)benzohydrazideCAS 1207454-56-5TalazoparibCAS 284028-89-32-[4-(trifluoromethyl)phenyl]-1,5,7,8-tetrahydrothiopyrano[4,3-d]pyrimidin-4-oneCAS 763113-22-0OlaparibCAS 1002310-00-0Tert-butyl 1-(2-chloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)ethylcarbamateCAS 1005174-17-3(E)-3-(2-Propyl-6-(trifluoromethyl)pyridin-3-yl)acrylic acid

RFQ questions for CAS 1174043-16-3

What are the key identifiers for Azd-2461 (CAS 1174043-16-3)?

Azd-2461 is identified by CAS 1174043-16-3, with molecular formula C22H22FN3O3, molecular weight 395.4, InChIKey HYNBNUYQTQIHJK-UHFFFAOYSA-N.

Does CAS 1174043-16-3 have reported biological target evidence?

ChEMBL contains qualifying experimental assay evidence associated with Poly [ADP-ribose] polymerase 1, Protein deacetylase HDAC6. These records do not establish therapeutic efficacy or clinical use.

Can I request a COA for CAS 1174043-16-3?

Yes. Submit an RFQ and specify COA requirements. Lot-specific COA depends on supplier confirmation.

Can I request supplier SDS for Azd-2461?

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Is CAS 1174043-16-3 available for quotation?

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