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Home/Compounds/CAS 120011-70-3
Formula C24H30ClNO3MW 416Research-use catalog entryCOA/SDS by request

Donepezil Hydrochloride

CAS Number: 120011-70-3

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Loading RDKit molecule structure...
InChIKey: XWAIAVWHZJNZQQ-UHFFFAOYSA-NC24H30ClNO3 | MW 416

Chemical Absolute Identifiers

CAS Number

120011-70-3

PubChem CID

5741

Molecular Formula

C24H30ClNO3

Molecular Weight

416 g/mol

Exact Mass

415.191422

InChIKey

XWAIAVWHZJNZQQ-UHFFFAOYSA-N

IUPAC Name

2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2,3-dihydroinden-1-one;hydrochloride

SMILES String

COC1=C(C=C2C(=C1)CC(C2=O)CC3CCN(CC3)CC4=CC=CC=C4)OC.Cl

Physical Properties

No physical property values available.

Properties are provided as catalog reference data and may be confirmed through supplier documentation when required.

Catalog Facts

Structural features

Donepezil Hydrochloride (CAS 120011-70-3) is listed in the Pharmaceutical Intermediates portfolio, with molecular formula C24H30ClNO3 and molecular weight 416. 00 g/mol.

Sourcing context

Catalog reference for RFQ preparation, supplier confirmation, and research chemical sourcing review.

Research use context

Intended for research-stage medicinal chemistry and intermediate synthesis workflows; structure-derived tags include nitrogen-containing heterocycle.

Documentation needs

COA/SDS status, availability, lead time, pack size, and shipment documentation can be confirmed during quotation.

Applications & Classification

Pharmaceutical Intermediate ResearchResearch intermediateCustom synthesis building blockPharmaceutical intermediate researchResearch chemical sourcingCustom synthesis and catalog availability reviewCOA, SDS, pricing, and fulfillment workflow
Biological target reference

ChEMBL reports experimental activity evidence for: Acetylcholinesterase (Torpedo californica) — 4 assays; Acetylcholinesterase (Mus musculus) — 2 assays; Acetylcholinesterase (Homo sapiens) — 10 assays; Acetylcholinesterase (Electrophorus electricus) — 11 assays; Cholinesterase (Equus caballus) — 6 assays. These records describe research assays and do not establish therapeutic efficacy or clinical use.

Acetylcholinesterase

Torpedo californica · SINGLE PROTEIN · 4 qualifying assays · 2 documents · best pChEMBL 8.47

Experimental evidence source: ChEMBL

Acetylcholinesterase

Mus musculus · SINGLE PROTEIN · 2 qualifying assays · 2 documents · best pChEMBL 8.24

Experimental evidence source: ChEMBL

Acetylcholinesterase

Homo sapiens · SINGLE PROTEIN · 10 qualifying assays · 6 documents · best pChEMBL 7.94

Experimental evidence source: ChEMBL

Acetylcholinesterase

Electrophorus electricus · SINGLE PROTEIN · 11 qualifying assays · 10 documents · best pChEMBL 7.85

Experimental evidence source: ChEMBL

Cholinesterase

Equus caballus · SINGLE PROTEIN · 6 qualifying assays · 6 documents · best pChEMBL 5.58

Experimental evidence source: ChEMBL

Safety & Handling

Handling & Storage

  • Keep container tightly closed and dry.
  • Store in a well-ventilated place.

PPE

Respiratory protection if needed

First Aid

  • Do not give anything to an unconscious person.
  • Rinse mouth with water.

Stability / Reactivity

  • Reactivity and reaction.
  • Carbon monoxide, carbon dioxide, hydrogen chloride, nitrogen oxides.

Disposal

  • Waste product.
  • Dispose of remaining and non-recyclable solutions to a licensed company.
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Fire Fighting

  • If necessary, wear a self-contained breathing apparatus during firefighting.

Accidental Release

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  • Sweep and shovel up.

For supplier-issued SDS, request documentation before handling, storage, shipment, or procurement decisions.

Preliminary Safety Reference

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Safety Reference / SDS Request

Names & Synonyms / External Identifiers

Chemical Name

Donepezil Hydrochloride

Names & Synonyms

Donepezil HClBNAGAricept ODTE2020ADLARITY
Show all synonyms
Aricept Evess1-Benzyl-4-((5,6-dimethoxy-1-indanon)-2-yl)methylpiperidine hclNAMZARIC COMPONENT DONEPEZIL HYDROCHLORIDEDonepezil HyrochlorideDonepezil Hyrochloride 5mgDonepezil Hydrochloride 10mgDonepezil Hydrochloride 5 mg1-benzyl-4-((5,6-dimethoxy-1-indanon)-2-yl)methylpiperidine hydrochloride(2RS)-2-((1-Benzylpiperidin-4-yl)methyl)-5,6-dimethoxy-2,3-dihydro-1H-inden-1-one monohydrochlorideAricept2-((1-Benzylpiperidin-4-yl)methyl)-5,6-dimethoxy-2,3-dihydro-1H-inden-1-one hydrochloride2,3-Dihydro-5,6-dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]methyl]-1H-inden-1-one hydrochlorideE 2020C24H30ClNO3Donepezil (Hydrochloride)
External Identifiers
EC NUMBER: 620-543-2DSSTOX SUBSTANCE ID: DTXSID0046698CHEMBL ID: CHEMBL1678UNII: 3O2T2PJ89DKEGG ID: D00670NCI THESAURUS CODE: C2603RXCUI: 236559
Literature & Patent References
DOI 10.1016/j.ejmech.2024.116388Tetrazole derivatives in the management of neurological disorders: Recent advances on synthesis and pharmacological aspects.DOI 10.1021/acsmedchemlett.3c00467Synthesis, Antiacetylcholinesterase Activity, and Molecular Dynamics Simulation of Aporphine-benzylpyridinium Conjugates.DOI 10.1039/d4md00113cDesign, synthesis, and biological evaluation of 1,2,4-oxadiazole-based derivatives as multitarget anti-Alzheimer agents.PMID 38229749Synthesis, Antiacetylcholinesterase Activity, and Molecular Dynamics Simulation of Aporphine-benzylpyridinium Conjugates.PMID 38614062Tetrazole derivatives in the management of neurological disorders: Recent advances on synthesis and pharmacological aspects.PMID 38911158Design, synthesis, and biological evaluation of 1,2,4-oxadiazole-based derivatives as multitarget anti-Alzheimer agents.DOI 10.1016/j.ejmech.2021.113154Design, synthesis, and biological evaluation of novel xanthone-alkylbenzylamine hybrids as multifunctional agents for the treatment of Alzheimer's disease.DOI 10.6019/CHEMBL4808148HDAC6 screening dataset using tau-based substrate in an enzymatic assay yields selective inhibitors and activators

Documentation & Compliance Facts

Compliance Facts

Shipment review: Required

Documentation available by request

Certificate of Analysis (COA): By request

Supplier Safety Data Sheet (SDS): By request

Purity and pack size confirmation: By request

Availability and lead time review: Confirmed by RFQ

Shipment documentation review: By request

For supplier-issued documentation by request, use the RFQ actions on this page.Review preliminary safety reference

What happens after RFQ

  1. 1We review the CAS identity, quantity, and documentation request.
  2. 2We check sourcing options, supplier availability, COA/SDS, purity, pack size, and lead time.
  3. 3We review destination and shipment documentation needs when applicable.
  4. 4We follow up with a quotation or clarification request.

Text Reference Cues

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Non-public related references

Desbenzyl donepezilCAS 120014-30-4
2-((1-Benzylpiperidin-4-yl)methylene)-5,6-dimethoxyindan-1-one, (E)-CAS 120014-07-5
5,6-Dimethoxy-2-(pyridin-4-ylmethyl)indan-1-oneCAS 4803-57-0
(E)-2-((1-benzyl-1,2,3,6-tetrahydropyridin-4-yl)methylene)-5,6-dimethoxy-2,3-dihydro-1H-inden-1-oneCAS 923571-20-4
Pyridinium, 4-[(2,3-dihydro-5,6-dimethoxy-1-oxo-1H-inden-2-yl)carbonyl]-1-(phenylmethyl)-, bromideCAS 923571-17-9

Non-public references are shown as text only and do not imply equivalence, availability, or shared use.

Catalog navigation

Related Catalog Entries

Other public CAS pages in this catalog. These links support navigation across additional intermediates and do not imply equivalence, availability, or shared use.

CAS 120014-30-4Desbenzyl donepezilCAS 120014-07-52-((1-Benzylpiperidin-4-yl)methylene)-5,6-dimethoxyindan-1-one, (E)-CAS 4803-57-05,6-Dimethoxy-2-(pyridin-4-ylmethyl)indan-1-oneCAS 923571-20-4(E)-2-((1-benzyl-1,2,3,6-tetrahydropyridin-4-yl)methylene)-5,6-dimethoxy-2,3-dihydro-1H-inden-1-oneCAS 923571-17-9Pyridinium, 4-[(2,3-dihydro-5,6-dimethoxy-1-oxo-1H-inden-2-yl)carbonyl]-1-(phenylmethyl)-, bromideCAS 321-64-2TacrineCAS 520-36-5ApigeninCAS 60940-34-3EbselenCAS 1684-40-81,2,3,4-tetrahydroacridin-9-ylazanium chlorideCAS 1002310-00-0Tert-butyl 1-(2-chloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)ethylcarbamate

RFQ questions for CAS 120011-70-3

What are the key identifiers for Donepezil Hydrochloride (CAS 120011-70-3)?

Donepezil Hydrochloride is identified by CAS 120011-70-3, with molecular formula C24H30ClNO3, molecular weight 416, InChIKey XWAIAVWHZJNZQQ-UHFFFAOYSA-N.

Does CAS 120011-70-3 have reported biological target evidence?

ChEMBL contains qualifying experimental assay evidence associated with Acetylcholinesterase, Acetylcholinesterase, Acetylcholinesterase, Acetylcholinesterase, Cholinesterase. These records do not establish therapeutic efficacy or clinical use.

Can I request a COA for CAS 120011-70-3?

Yes. Submit an RFQ and specify COA requirements. Lot-specific COA depends on supplier confirmation.

Can I request supplier SDS for Donepezil Hydrochloride?

Yes. Supplier SDS can be requested through the RFQ workflow before handling, storage, shipment, or procurement decisions.

Is CAS 120011-70-3 available for quotation?

Availability, pack size, lead time, and pricing are confirmed through RFQ.

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