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Home/Compounds/CAS 1207454-56-5
Formula C19H14F2N6OMW 380.4Research-use catalog entryCOA/SDS by request

Talazoparib

CAS Number: 1207454-56-5

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Loading RDKit molecule structure...
InChIKey: HWGQMRYQVZSGDQ-HZPDHXFCSA-NC19H14F2N6O | MW 380.4

Chemical Absolute Identifiers

CAS Number

1207454-56-5

PubChem CID

Not available

Molecular Formula

C19H14F2N6O

Molecular Weight

380.4 g/mol

Exact Mass

380.119715

InChIKey

HWGQMRYQVZSGDQ-HZPDHXFCSA-N

IUPAC Name

(11S,12R)-7-fluoro-11-(4-fluorophenyl)-12-(2-methyl-1,2,4-triazol-3-yl)-2,3,10-triazatricyclo[7.3.1.05,13]trideca-1,5(13),6,8-tetraen-4-one

SMILES String

Cn1ncnc1[C@H]1c2n[nH]c(=O)c3cc(F)cc(c23)N[C@@H]1c1ccc(F)cc1

Physical Properties

No physical property values available.

Properties are provided as catalog reference data and may be confirmed through supplier documentation when required.

Catalog Facts

Structural features

Talazoparib (CAS 1207454-56-5) is listed in the Pharmaceutical Intermediates portfolio, with molecular formula C19H14F2N6O and molecular weight 380. 40 g/mol.

Sourcing context

Catalog reference for RFQ preparation, supplier confirmation, and research chemical sourcing review.

Research use context

Intended for research-stage medicinal chemistry and intermediate synthesis workflows; structure-derived tags include nitrogen-containing heterocycle.

Documentation needs

COA/SDS status, availability, lead time, pack size, and shipment documentation can be confirmed during quotation.

Applications & Classification

Pharmaceutical Intermediate ResearchResearch intermediateCustom synthesis building blockPharmaceutical intermediate researchResearch chemical sourcingCustom synthesis and catalog availability reviewCOA, SDS, pricing, and fulfillment workflow
Biological target reference

ChEMBL reports experimental activity evidence for: Poly [ADP-ribose] polymerase 2 (Homo sapiens) — 12 assays; Poly [ADP-ribose] polymerase 1 (Homo sapiens) — 26 assays; Poly [ADP-ribose] polymerase tankyrase-1 (Homo sapiens) — 3 assays; Protein deacetylase HDAC6 (Homo sapiens) — 2 assays. These records describe research assays and do not establish therapeutic efficacy or clinical use.

Poly [ADP-ribose] polymerase 2

Homo sapiens · SINGLE PROTEIN · 12 qualifying assays · 11 documents · best pChEMBL 9.7

Experimental evidence source: ChEMBL

Poly [ADP-ribose] polymerase 1

Homo sapiens · SINGLE PROTEIN · 26 qualifying assays · 20 documents · best pChEMBL 9.24

Experimental evidence source: ChEMBL

Poly [ADP-ribose] polymerase tankyrase-1

Homo sapiens · SINGLE PROTEIN · 3 qualifying assays · 2 documents · best pChEMBL 7.85

Experimental evidence source: ChEMBL

Protein deacetylase HDAC6

Homo sapiens · SINGLE PROTEIN · 2 qualifying assays · 1 documents

Experimental evidence source: ChEMBL

Safety & Handling

Safety and handling reference content is available through documentation requests.

For supplier-issued SDS, request documentation before handling, storage, shipment, or procurement decisions.

Preliminary Safety Reference

For supplier-issued SDS or COA, submit a documentation request.

Safety Reference / SDS Request

Names & Synonyms / External Identifiers

Chemical Name

Talazoparib

Names & Synonyms

BMN 6733H-Pyrido(4,3,2-de)phthalazin-3-one, 5-fluoro-8-(4-fluorophenyl)-2,7,8,9-tetrahydro-9-(1-methyl-1H-1,2,4-triazol-5-yl)-, (8S,9R)-talazoparibum(11S,12R)-7-fluoro-11-(4-fluorophenyl)-12-(1-methyl-1H-1,2,4-triazol-5-yl)-2,3,10-triazatricyclo(7.3.1.0^(5,13))trideca-1,5,7,9(13)-tetraen-4-oneTalazoparib (BMN 673)
Show all synonyms
(8S,9R)-5-fluoro-8-(4-fluorophenyl)-9-(1-methyl-1H-1,2,4-triazol-5-yl)-8,9-dihydro-2H-pyrido[4,3,2-de]phthalazin-3(7H)-one(8s,9r)-5-Fluoro-8-(4-Fluorophenyl)-9-(1-Methyl-1h-1,2,4-Triazol-5-Yl)-2,7,8,9-Tetrahydro-3h-Pyrido[4,3,2-De]phthalazin-3-One(8S,9R)-5-Fluoro-8-(4-fluorophenyl)-2,7,8,9-tetrahydro-9-(1-methyl-1H-1,2,4-triazol-5-yl)-3H-pyrido[4,3,2-de]phthalazine-3-one(8S,9R)-BMN 673(8S,9R)-5-Fluoro-8-(4-fluorophenyl)-2,7,8,9-tetrahydro-9-(1-methyl-1H-1,2,4-triazol-5-yl)-3H-pyrido[4,3,2-de]phthalazin-3-oneTalazoparib [USAN:INN]4pjt2YQTALAZOPARIB [MI]Talazoparib(BMN-673)TALAZOPARIB [INN]Talazoparib (USAN/INN)TALAZOPARIB [USAN]Talazoparib (BMN-673)
External Identifiers
EC NUMBER: 815-271-8DSSTOX SUBSTANCE ID: DTXSID001025928CHEMBL ID: CHEMBL3137320CHEMBL ID: CHEMBL5724798CHEBI ID: CHEBI:231344UNII: 9QHX048FRVDRUGBANK ID: DB11760KEGG ID: D10732METABOLOMICS WORKBENCH ID: 152862NCI THESAURUS CODE: C95733PHARMGKB ID: PA166182740RXCUI: 2099704WIKIDATA ID: Q25100990
Literature & Patent References
DOI 10.1021/acs.jmedchem.4c02642The Potential of PARP Inhibitors as Antitumor Drugs and the Perspective of Molecular Design.DOI 10.1021/acs.jmedchem.5c00184Discovery of New Azaindole Metallo-Deubiquitinase CSN5 Inhibitors.PMID 39723587The Potential of PARP Inhibitors as Antitumor Drugs and the Perspective of Molecular Design.PMID 40053484Discovery of New Azaindole Metallo-Deubiquitinase CSN5 Inhibitors.DOI 10.1016/j.ejmech.2023.116114An <sup>19</sup>F NMR fragment-based approach for the discovery and development of BRCA2-RAD51 inhibitors to pursuit synthetic lethality in combination with PARP inhibition in pancreatic cancer.DOI 10.1016/j.ejmech.2024.116535Poly (ADP-ribose) polymerase (PARP) inhibitors as anticancer agents: An outlook on clinical progress, synthetic strategies, biological activity, and structure-activity relationship.DOI 10.1021/acs.jmedchem.3c02460Design of Selective PARP-1 Inhibitors and Antitumor Studies.DOI 10.1021/acs.jmedchem.4c00077Rational Design of PARP1/c-Met Dual Inhibitors for Overcoming PARP1 Inhibitor Resistance Induced by c-Met Overexpression.

Documentation & Compliance Facts

Compliance Facts

Shipment review: Required

Documentation available by request

Certificate of Analysis (COA): By request

Supplier Safety Data Sheet (SDS): By request

Purity and pack size confirmation: By request

Availability and lead time review: Confirmed by RFQ

Shipment documentation review: By request

For supplier-issued documentation by request, use the RFQ actions on this page.Review preliminary safety reference

What happens after RFQ

  1. 1We review the CAS identity, quantity, and documentation request.
  2. 2We check sourcing options, supplier availability, COA/SDS, purity, pack size, and lead time.
  3. 3We review destination and shipment documentation needs when applicable.
  4. 4We follow up with a quotation or clarification request.

Text Reference Cues

Show non-linked catalog cues

Non-public related references

Talazoparib TosylateCAS 1373431-65-2
5-Quinolinecarboxylic acid, 7-fluoro-2-(4-fluorophenyl)-1,2,3,4-tetrahydro-3-(1-methyl-1H-1,2,4-triazol-5-yl)-4-oxo-, methyl esterCAS 1322616-36-3
(2S,3S)-methyl 7-fluoro-2-(4-fluorophenyl)-3-(1-methyl-1H-1,2,4-triazol-5-yl)-4-oxo-1,2,3,4-tetrahydroquinoline-5-carboxylateCAS 1373329-52-2
1(3H)-Isobenzofuranone, 6-fluoro-3-((1-methyl-1H-1,2,4-triazol-5-yl)methylene)-4-nitro-, (3Z)-CAS 1322616-34-1
methyl 5-fluoro-2-(2-(1-methyl-1H-1,2,4-triazol-5-yl)acetyl)-3-nitrobenzoateCAS 1322879-81-1

Non-public references are shown as text only and do not imply equivalence, availability, or shared use.

Catalog navigation

Related Catalog Entries

Other public CAS pages in this catalog. These links support navigation across additional intermediates and do not imply equivalence, availability, or shared use.

CAS 1373431-65-2Talazoparib TosylateCAS 1322616-36-35-Quinolinecarboxylic acid, 7-fluoro-2-(4-fluorophenyl)-1,2,3,4-tetrahydro-3-(1-methyl-1H-1,2,4-triazol-5-yl)-4-oxo-, methyl esterCAS 1373329-52-2(2S,3S)-methyl 7-fluoro-2-(4-fluorophenyl)-3-(1-methyl-1H-1,2,4-triazol-5-yl)-4-oxo-1,2,3,4-tetrahydroquinoline-5-carboxylateCAS 284028-89-32-[4-(trifluoromethyl)phenyl]-1,5,7,8-tetrahydrothiopyrano[4,3-d]pyrimidin-4-oneCAS 763113-22-0OlaparibCAS 1174043-16-3Azd-2461CAS 1002310-00-0Tert-butyl 1-(2-chloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)ethylcarbamateCAS 1005174-17-3(E)-3-(2-Propyl-6-(trifluoromethyl)pyridin-3-yl)acrylic acidCAS 1018125-49-92-(3-Cyclopropyl-6-ethyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl)acetic acidCAS 1018128-07-8Isopropyl 4-chloro-2-methylquinoline-6-carboxylate

RFQ questions for CAS 1207454-56-5

What are the key identifiers for Talazoparib (CAS 1207454-56-5)?

Talazoparib is identified by CAS 1207454-56-5, with molecular formula C19H14F2N6O, molecular weight 380.4, InChIKey HWGQMRYQVZSGDQ-HZPDHXFCSA-N.

Does CAS 1207454-56-5 have reported biological target evidence?

ChEMBL contains qualifying experimental assay evidence associated with Poly [ADP-ribose] polymerase 2, Poly [ADP-ribose] polymerase 1, Poly [ADP-ribose] polymerase tankyrase-1, Protein deacetylase HDAC6. These records do not establish therapeutic efficacy or clinical use.

Can I request a COA for CAS 1207454-56-5?

Yes. Submit an RFQ and specify COA requirements. Lot-specific COA depends on supplier confirmation.

Can I request supplier SDS for Talazoparib?

Yes. Supplier SDS can be requested through the RFQ workflow before handling, storage, shipment, or procurement decisions.

Is CAS 1207454-56-5 available for quotation?

Availability, pack size, lead time, and pricing are confirmed through RFQ.

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