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- Purity
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CAS Number: 1231929-97-7
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CAS Number
1231929-97-7
PubChem CID
46220502
Molecular Formula
C27H32F2N8
Molecular Weight
506.6 g/mol
Exact Mass
506.271799
InChIKey
UZWDCWONPYILKI-UHFFFAOYSA-N
IUPAC Name
N-[5-[(4-ethylpiperazin-1-yl)methyl]-2-pyridinyl]-5-fluoro-4-(7-fluoro-2-methyl-3-propan-2-ylbenzimidazol-5-yl)pyrimidin-2-amine
SMILES String
CCN1CCN(Cc2ccc(Nc3ncc(F)c(-c4cc(F)c5nc(C)n(C(C)C)c5c4)n3)nc2)CC1
No physical property values available.
Properties are provided as catalog reference data and may be confirmed through supplier documentation when required.
Structural features
Abemaciclib (CAS 1231929-97-7) is listed in the Pharmaceutical Intermediates portfolio, with molecular formula C27H32F2N8 and molecular weight 506. 60 g/mol.
Sourcing context
Catalog reference for RFQ preparation, supplier confirmation, and research chemical sourcing review.
Research use context
Intended for research-stage medicinal chemistry and intermediate synthesis workflows; structure-derived tags include nitrogen-containing heterocycle.
Documentation needs
COA/SDS status, availability, lead time, pack size, and shipment documentation can be confirmed during quotation.
ChEMBL reports experimental activity evidence for: Cyclin-dependent kinase 4 (Homo sapiens) — 13 assays; CDK6/cyclin D1 (Homo sapiens) — 10 assays; Cyclin-dependent kinase 4/cyclin D1 (Homo sapiens) — 16 assays; Dual specificity protein kinase CLK1 (Homo sapiens) — 7 assays; CDK4/Cyclin D3 (Homo sapiens) — 9 assays. These records describe research assays and do not establish therapeutic efficacy or clinical use.
Cyclin-dependent kinase 4
Homo sapiens · SINGLE PROTEIN · 13 qualifying assays · 13 documents · best pChEMBL 9.59
Experimental evidence source: ChEMBL
CDK6/cyclin D1
Homo sapiens · PROTEIN COMPLEX · 10 qualifying assays · 7 documents · best pChEMBL 9.37
Experimental evidence source: ChEMBL
Cyclin-dependent kinase 4/cyclin D1
Homo sapiens · PROTEIN COMPLEX · 16 qualifying assays · 12 documents · best pChEMBL 9.34
Experimental evidence source: ChEMBL
Dual specificity protein kinase CLK1
Homo sapiens · SINGLE PROTEIN · 7 qualifying assays · 4 documents · best pChEMBL 9.07
Experimental evidence source: ChEMBL
CDK4/Cyclin D3
Homo sapiens · PROTEIN COMPLEX · 9 qualifying assays · 7 documents · best pChEMBL 8.82
Experimental evidence source: ChEMBL
Safety and handling reference content is available through documentation requests.
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Preliminary Safety Reference
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Safety Reference / SDS RequestCatalog navigation
Other public CAS pages in this catalog. These links support navigation across additional intermediates and do not imply equivalence, availability, or shared use.
Abemaciclib is identified by CAS 1231929-97-7, with molecular formula C27H32F2N8, molecular weight 506.6, InChIKey UZWDCWONPYILKI-UHFFFAOYSA-N.
ChEMBL contains qualifying experimental assay evidence associated with Cyclin-dependent kinase 4, CDK6/cyclin D1, Cyclin-dependent kinase 4/cyclin D1, Dual specificity protein kinase CLK1, CDK4/Cyclin D3. These records do not establish therapeutic efficacy or clinical use.
Yes. Submit an RFQ and specify COA requirements. Lot-specific COA depends on supplier confirmation.
Yes. Supplier SDS can be requested through the RFQ workflow before handling, storage, shipment, or procurement decisions.
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