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Home/Compounds/CAS 1262888-28-7
Formula C15H11F2N3MW 271.26Research-use catalog entryCOA/SDS by request

Spautin-1

CAS Number: 1262888-28-7

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Loading RDKit molecule structure...
InChIKey: AWIVHRPYFSSVOG-UHFFFAOYSA-NC15H11F2N3 | MW 271.26

Chemical Absolute Identifiers

CAS Number

1262888-28-7

PubChem CID

51037431

Molecular Formula

C15H11F2N3

Molecular Weight

271.26 g/mol

Exact Mass

271.092104

InChIKey

AWIVHRPYFSSVOG-UHFFFAOYSA-N

IUPAC Name

6-fluoro-N-[(4-fluorophenyl)methyl]quinazolin-4-amine

SMILES String

Fc1ccc(CNc2ncnc3ccc(F)cc23)cc1

Physical Properties

No physical property values available.

Properties are provided as catalog reference data and may be confirmed through supplier documentation when required.

Catalog Facts

Structural features

Spautin-1 (CAS 1262888-28-7) is listed in the Inhibitors and Agonists portfolio, with molecular formula C15H11F2N3 and molecular weight 271. 26 g/mol.

Sourcing context

Catalog reference for RFQ preparation, supplier confirmation, and research chemical sourcing review.

Research use context

Intended for biochemical and pharmacology research workflows; structure-derived tags include nitrogen-containing heterocycle.

Documentation needs

COA/SDS status, availability, lead time, pack size, and shipment documentation can be confirmed during quotation.

Applications & Classification

Bioactivity ScreeningResearch intermediateCustom synthesis building blockResearch chemical sourcingCustom synthesis and catalog availability reviewCOA, SDS, pricing, and fulfillment workflow
Biological target reference

ChEMBL reports experimental activity evidence for: Ubiquitin carboxyl-terminal hydrolase 10 (Homo sapiens) — 3 assays; Ubiquitin carboxyl-terminal hydrolase 13 (Homo sapiens) — 3 assays; Phosphatidylinositol 3-kinase catalytic subunit type 3 (Homo sapiens) — 2 assays; Protein deacetylase HDAC6 (Homo sapiens) — 2 assays. These records describe research assays and do not establish therapeutic efficacy or clinical use.

Ubiquitin carboxyl-terminal hydrolase 10

Homo sapiens · SINGLE PROTEIN · 3 qualifying assays · 3 documents · best pChEMBL 6.24

Experimental evidence source: ChEMBL

Ubiquitin carboxyl-terminal hydrolase 13

Homo sapiens · SINGLE PROTEIN · 3 qualifying assays · 3 documents · best pChEMBL 6.22

Experimental evidence source: ChEMBL

Phosphatidylinositol 3-kinase catalytic subunit type 3

Homo sapiens · SINGLE PROTEIN · 2 qualifying assays · 2 documents · best pChEMBL 6.13

Experimental evidence source: ChEMBL

Protein deacetylase HDAC6

Homo sapiens · SINGLE PROTEIN · 2 qualifying assays · 1 documents

Experimental evidence source: ChEMBL

Safety & Handling

Safety and handling reference content is available through documentation requests.

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Preliminary Safety Reference

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Names & Synonyms / External Identifiers

Chemical Name

Spautin-1

Names & Synonyms

6-Fluoro-N-(4-fluorobenzyl)quinazolin-4-amineSpautin 16-Fluoro-N-[(4-Fluorophenyl)methyl]-4-quinazolinamine4-Quinazolinamine, 6-fluoro-N-[(4-fluorophenyl)methyl]-Spautin 1?
Show all synonyms
MBCQ derivative C43Spautin-1, >=98% (HPLC)s7888P26136-Fluoro-N-(4-fluorobenzyl)-4-quinazolinamine6-Fluoro-N[(4-fluorophenyl)methyl]-4-quinazolinamine
External Identifiers
EC NUMBER: 802-904-8DSSTOX SUBSTANCE ID: DTXSID101318621CHEMBL ID: CHEMBL2391504
Literature & Patent References
DOI 10.1016/j.ejmech.2023.116117Targeting autophagy drug discovery: Targets, indications and development trends.DOI 10.1016/j.ejmech.2024.116468Discovery of potent small molecule ubiquitin-specific protease 10 inhibitors with anti-hepatocellular carcinoma activity through regulating YAP expression.DOI 10.1016/j.ejmech.2024.116688Autophagy modulation in cancer therapy: Challenges coexist with opportunities.DOI 10.6019/CHEMBL5724796Tm Shift (DSF) assay results for EUbOPEN Chemogenomics LibraryPMID 38295689Targeting autophagy drug discovery: Targets, indications and development trends.PMID 38718626Discovery of potent small molecule ubiquitin-specific protease 10 inhibitors with anti-hepatocellular carcinoma activity through regulating YAP expression.PMID 39033611Autophagy modulation in cancer therapy: Challenges coexist with opportunities.DOI 10.1016/j.bmcl.2022.129066Second generation Spautin-1 analogues targeting EGFR-mutant non-small cell lung cancer cells.

Documentation & Compliance Facts

Compliance Facts

Shipment review: Required

Documentation available by request

Certificate of Analysis (COA): By request

Supplier Safety Data Sheet (SDS): By request

Purity and pack size confirmation: By request

Availability and lead time review: Confirmed by RFQ

Shipment documentation review: By request

For supplier-issued documentation by request, use the RFQ actions on this page.Review preliminary safety reference

What happens after RFQ

  1. 1We review the CAS identity, quantity, and documentation request.
  2. 2We check sourcing options, supplier availability, COA/SDS, purity, pack size, and lead time.
  3. 3We review destination and shipment documentation needs when applicable.
  4. 4We follow up with a quotation or clarification request.

Text Reference Cues

Additional text reference cues are not available for this catalog entry.

Non-public references are shown as text only and do not imply equivalence, availability, or shared use.

Catalog navigation

Related Catalog Entries

Other public CAS pages in this catalog. These links support navigation across additional intermediates and do not imply equivalence, availability, or shared use.

CAS 16499-61-94-Chloro-6-fluoroquinazolineCAS 571190-30-2PalbociclibCAS 870281-82-6IdelalisibCAS 938440-64-3Ku-0063794CAS 1009298-09-2Azd8055CAS 60940-34-3EbselenCAS 1002310-00-0Tert-butyl 1-(2-chloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)ethylcarbamateCAS 1005174-17-3(E)-3-(2-Propyl-6-(trifluoromethyl)pyridin-3-yl)acrylic acidCAS 1018125-49-92-(3-Cyclopropyl-6-ethyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl)acetic acidCAS 1018128-07-8Isopropyl 4-chloro-2-methylquinoline-6-carboxylate

RFQ questions for CAS 1262888-28-7

What are the key identifiers for Spautin-1 (CAS 1262888-28-7)?

Spautin-1 is identified by CAS 1262888-28-7, with molecular formula C15H11F2N3, molecular weight 271.26, InChIKey AWIVHRPYFSSVOG-UHFFFAOYSA-N.

Does CAS 1262888-28-7 have reported biological target evidence?

ChEMBL contains qualifying experimental assay evidence associated with Ubiquitin carboxyl-terminal hydrolase 10, Ubiquitin carboxyl-terminal hydrolase 13, Phosphatidylinositol 3-kinase catalytic subunit type 3, Protein deacetylase HDAC6. These records do not establish therapeutic efficacy or clinical use.

Can I request a COA for CAS 1262888-28-7?

Yes. Submit an RFQ and specify COA requirements. Lot-specific COA depends on supplier confirmation.

Can I request supplier SDS for Spautin-1?

Yes. Supplier SDS can be requested through the RFQ workflow before handling, storage, shipment, or procurement decisions.

Is CAS 1262888-28-7 available for quotation?

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