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Home/Compounds/CAS 128517-07-7
Formula C24H36N4O6S2MW 540.7Research-use catalog entryCOA/SDS by request

Romidepsin

CAS Number: 128517-07-7

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Loading RDKit molecule structure...
InChIKey: OHRURASPPZQGQM-GCCNXGTGSA-NC24H36N4O6S2 | MW 540.7

Chemical Absolute Identifiers

CAS Number

128517-07-7

PubChem CID

5352062

Molecular Formula

C24H36N4O6S2

Molecular Weight

540.7 g/mol

Exact Mass

540.207627

InChIKey

OHRURASPPZQGQM-GCCNXGTGSA-N

IUPAC Name

(1S,4S,7Z,10S,16E,21R)-7-ethylidene-4,21-di(propan-2-yl)-2-oxa-12,13-dithia-5,8,20,23-tetrazabicyclo[8.7.6]tricos-16-ene-3,6,9,19,22-pentone

SMILES String

C/C=C1\NC(=O)[C@H]2CSSCC/C=C/[C@H](CC(=O)N[C@H](C(C)C)C(=O)N2)OC(=O)[C@H](C(C)C)NC1=O

Physical Properties

No physical property values available.

Properties are provided as catalog reference data and may be confirmed through supplier documentation when required.

Catalog Facts

Structural features

Romidepsin (CAS 128517-07-7) is listed in the Pharmaceutical Intermediates portfolio, with molecular formula C24H36N4O6S2 and molecular weight 540. 70 g/mol.

Sourcing context

Catalog reference for RFQ preparation, supplier confirmation, and research chemical sourcing review.

Research use context

Intended for research-stage medicinal chemistry and intermediate synthesis workflows; structure-derived tags include nitrogen-containing heterocycle.

Documentation needs

COA/SDS status, availability, lead time, pack size, and shipment documentation can be confirmed during quotation.

Applications & Classification

Pharmaceutical Intermediate ResearchResearch intermediateCustom synthesis building blockPharmaceutical intermediate researchResearch chemical sourcingCustom synthesis and catalog availability reviewCOA, SDS, pricing, and fulfillment workflow
Biological target reference

ChEMBL reports experimental activity evidence for: Histone deacetylase 2 (Homo sapiens) — 23 assays; Histone deacetylase 3 (Homo sapiens) — 10 assays; Histone deacetylase 8 (Homo sapiens) — 10 assays; Histone deacetylase 1 (Homo sapiens) — 36 assays; Histone deacetylase 11 (Homo sapiens) — 4 assays. These records describe research assays and do not establish therapeutic efficacy or clinical use.

Histone deacetylase 2

Homo sapiens · SINGLE PROTEIN · 23 qualifying assays · 19 documents · best pChEMBL 10.42

Experimental evidence source: ChEMBL

Histone deacetylase 3

Homo sapiens · SINGLE PROTEIN · 10 qualifying assays · 8 documents · best pChEMBL 9.82

Experimental evidence source: ChEMBL

Histone deacetylase 8

Homo sapiens · SINGLE PROTEIN · 10 qualifying assays · 10 documents · best pChEMBL 9.82

Experimental evidence source: ChEMBL

Histone deacetylase 1

Homo sapiens · SINGLE PROTEIN · 36 qualifying assays · 28 documents · best pChEMBL 9.7

Experimental evidence source: ChEMBL

Histone deacetylase 11

Homo sapiens · SINGLE PROTEIN · 4 qualifying assays · 4 documents · best pChEMBL 9.52

Experimental evidence source: ChEMBL

Safety & Handling

Safety and handling reference content is available through documentation requests.

For supplier-issued SDS, request documentation before handling, storage, shipment, or procurement decisions.

Preliminary Safety Reference

For supplier-issued SDS or COA, submit a documentation request.

Safety Reference / SDS Request

Names & Synonyms / External Identifiers

Chemical Name

Romidepsin

Names & Synonyms

IstodaxFK228ChromadaxAntibiotic FR 901228romidepsina
Show all synonyms
romidepsineromidepsinum(1S,4S,7Z,10S,16E,21R)-7-ethylidene-4,21-di(propan-2-yl)-2-oxa-12,13-dithia-5,8,20,23-tetraazabicyclo[8.7.6]tricos-16-ene-3,6,9,19,22-pentoneL-Valine, N-(3-hydroxy-7-mercapto-1-oxo-4-heptenyl)-D-valyl-D-cysteinyl-(Z)-2,3-didehydro-2-aminobutanoyl-, xi-lactone, cyclic (1-2)-disulfide, (S-(E))-(1S,4S,7Z,10S,16E,21R)-7-ethylidene-4,21-di(propan-2-yl)-2-oxa-12,13-dithia-5,8,20,23-tetraazabicyclo(8.7.6)tricos-16-ene-3,6,9,19,22-pentone(1S,4S,7Z,10S,16E,21R)-7-ethylidene-4,21-di(propan-2-yl)-2-oxa-12,13-dithia-5,8,20,23-tetrazabicyclo(8.7.6)tricos-16-ene-3,6,9,19,22-pentoneDepsipeptideFK 228FR 901228(1S,4S,7Z,10S,16E,21R)-7-ethylidene-4,21-diisopropyl-2-oxa-12,13-dithia-5,8,20,23-tetraazabicyclo[8.7.6]tricos-16-ene-3,6,9,19,22-pentaone(1S,4S,7Z,10S,16E,21R)-7-ethylidene-4,21-bis(propan-2-yl)-2-oxa-12,13-dithia-5,8,20,23-tetraazabicyclo[8.7.6]tricos-16-ene-3,6,9,19,22-pentone(1S,4S,7Z,10S,16E,21R)-7-ethylidene-4,21-bis(1methylethyl)-2-oxa-12,13-dithia-5,8,20,23-tetraazabicyclo[8.7.6]tricos-16ene-3,6,9,19,22-pentoneCyclo[(2Z)-2-amino-2-butenoyl-L-val yl-(3S,4E)-3-hydroxy-7-mercapto-4-heptenoyl-D-valy l-D-cysteinyl], cyclic (3-5) disulfideCyclo[(2Z)-2-amino-2-butenoyl-L-valyl-(3S,4E)-3-hydroxy-7-mercapto-4-heptenoyl-D-valyl-D-cysteinyl], cyclic (3 inverted exclamation marku5)-disulfide
External Identifiers
EC NUMBER: 686-179-1CHEMBL ID: CHEMBL343448CHEBI ID: CHEBI:61080UNII: CX3T89XQBKDRUGBANK ID: DB06176KEGG ID: D06637METABOLOMICS WORKBENCH ID: 52651NCI THESAURUS CODE: C1544PHARMGKB ID: PA166161306RXCUI: 877510WIKIDATA ID: Q7363205
Literature & Patent References
DOI 10.1016/j.ejmech.2023.116109Advancements in dual-target inhibitors of PI3K for tumor therapy: Clinical progress, development strategies, prospects.DOI 10.1016/j.ejmech.2024.116324Synergistic therapeutics: Co-targeting histone deacetylases and ribonucleotide reductase for enhanced cancer treatment.DOI 10.1016/j.ejmech.2024.116456An insight into the pharmacology of cysteine/methionine containing peptide drugs.DOI 10.1016/j.ejmech.2024.116782Development of peptoid-based heteroaryl-decorated histone deacetylase (HDAC) inhibitors with dual-stage antiplasmodial activity.DOI 10.1021/acs.jmedchem.4c00729Discovery of a Novel Benzimidazole Derivative Targeting Histone Deacetylase to Induce Ferroptosis and Trigger Immunogenic Cell Death.DOI 10.6019/CHEMBL5724709EUbOPEN Chemogenomics Library - IncuCyteDOI 10.6019/CHEMBL5724796Tm Shift (DSF) assay results for EUbOPEN Chemogenomics LibraryPMID 38183777Advancements in dual-target inhibitors of PI3K for tumor therapy: Clinical progress, development strategies, prospects.

Documentation & Compliance Facts

Compliance Facts

Shipment review: Required

Documentation available by request

Certificate of Analysis (COA): By request

Supplier Safety Data Sheet (SDS): By request

Purity and pack size confirmation: By request

Availability and lead time review: Confirmed by RFQ

Shipment documentation review: By request

For supplier-issued documentation by request, use the RFQ actions on this page.Review preliminary safety reference

What happens after RFQ

  1. 1We review the CAS identity, quantity, and documentation request.
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  3. 3We review destination and shipment documentation needs when applicable.
  4. 4We follow up with a quotation or clarification request.

Text Reference Cues

Additional text reference cues are not available for this catalog entry.

Non-public references are shown as text only and do not imply equivalence, availability, or shared use.

Catalog navigation

Related Catalog Entries

Other public CAS pages in this catalog. These links support navigation across additional intermediates and do not imply equivalence, availability, or shared use.

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RFQ questions for CAS 128517-07-7

What are the key identifiers for Romidepsin (CAS 128517-07-7)?

Romidepsin is identified by CAS 128517-07-7, with molecular formula C24H36N4O6S2, molecular weight 540.7, InChIKey OHRURASPPZQGQM-GCCNXGTGSA-N.

Does CAS 128517-07-7 have reported biological target evidence?

ChEMBL contains qualifying experimental assay evidence associated with Histone deacetylase 2, Histone deacetylase 3, Histone deacetylase 8, Histone deacetylase 1, Histone deacetylase 11. These records do not establish therapeutic efficacy or clinical use.

Can I request a COA for CAS 128517-07-7?

Yes. Submit an RFQ and specify COA requirements. Lot-specific COA depends on supplier confirmation.

Can I request supplier SDS for Romidepsin?

Yes. Supplier SDS can be requested through the RFQ workflow before handling, storage, shipment, or procurement decisions.

Is CAS 128517-07-7 available for quotation?

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