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Home/Compounds/CAS 130-86-9
Formula C20H19NO5MW 353.4Research-use catalog entryCOA/SDS by request

Protopine

CAS Number: 130-86-9

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Loading RDKit molecule structure...
InChIKey: GPTFURBXHJWNHR-UHFFFAOYSA-NC20H19NO5 | MW 353.4

Chemical Absolute Identifiers

CAS Number

130-86-9

PubChem CID

4970

Molecular Formula

C20H19NO5

Molecular Weight

353.4 g/mol

Exact Mass

353.126323

InChIKey

GPTFURBXHJWNHR-UHFFFAOYSA-N

IUPAC Name

15-methyl-7,9,19,21-tetraoxa-15-azapentacyclo[15.7.0.04,12.06,10.018,22]tetracosa-1(17),4,6(10),11,18(22),23-hexaen-3-one

SMILES String

CN1CCC2=CC3=C(C=C2C(=O)CC4=C(C1)C5=C(C=C4)OCO5)OCO3

Physical Properties

Melting Point

208.0 °C

Density

1.4 g/cm³

Water Solubility

15 mol/L

Properties are provided as catalog reference data and may be confirmed through supplier documentation when required.

Catalog Facts

Structural features

Protopine (CAS 130-86-9) is listed in the Advanced Chemicals portfolio, with molecular formula C20H19NO5 and molecular weight 353. 40 g/mol.

Sourcing context

Catalog reference for RFQ preparation, supplier confirmation, and research chemical sourcing review.

Research use context

Intended for research building-block and synthetic chemistry workflows; structure-derived tags include nitrogen-containing heterocycle.

Documentation needs

COA/SDS status, availability, lead time, pack size, and shipment documentation can be confirmed during quotation.

Applications & Classification

Natural Product ResearchSynthetic ChemistryResearch intermediateCustom synthesis building blockResearch chemical sourcingCustom synthesis and catalog availability reviewCOA, SDS, pricing, and fulfillment workflow
Biological target reference

ChEMBL reports experimental activity evidence for: Thyrotropin receptor (Homo sapiens) — 2 assays; Cytochrome P450 3A4 (Homo sapiens) — 2 assays. These records describe research assays and do not establish therapeutic efficacy or clinical use.

Thyrotropin receptor

Homo sapiens · SINGLE PROTEIN · 2 qualifying assays · 1 documents · best pChEMBL 4.9

Experimental evidence source: ChEMBL

Cytochrome P450 3A4

Homo sapiens · SINGLE PROTEIN · 2 qualifying assays · 1 documents · best pChEMBL 4.6

Experimental evidence source: ChEMBL

Safety & Handling

Handling & Storage

  • Keep container tightly closed and dry.
  • Store in a well-ventilated place.

PPE

Respiratory protection if needed

First Aid

  • Do not give anything to an unconscious person.
  • Rinse mouth with water.

Stability / Reactivity

  • Reactivity.
  • Carbon monoxide, carbon dioxide, nitrogen oxides.

Disposal

  • Dispose of the remaining and non-recyclable solution to a licensed company.
  • Contact a professional agency with a waste disposal license to handle this substance.
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Fire Fighting

  • If necessary, wear a self-contained breathing apparatus for firefighting.

Accidental Release

  • Do not generate dust when collecting and disposing.
  • Sweep and shovel up.

For supplier-issued SDS, request documentation before handling, storage, shipment, or procurement decisions.

Preliminary Safety Reference

For supplier-issued SDS or COA, submit a documentation request.

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Names & Synonyms / External Identifiers

Chemical Name

Protopine

Names & Synonyms

CorydinineBiflorineMacleyineFumarineProtopin
Show all synonyms
7-Methyl-2,3:9,10-bis(methylenedioxy)-7,13a-secoberbin-13a-one7,13a-Secoberbin-13a-one, 7-methyl-2,3:9,10-bis(methylenedioxy)-Bis[1,3]benzodioxolo[4,5-c:5',6'-g]azecin-13(5H)-one, 4,6,7,14-tetrahydro-5-methyl-4,6,7,14-Tetrahydro-5-methyl-bis(1,3)benzodioxolo(4,5-c-5',6'-g)azecin-13(5H)-oneBis(1,3)benzodioxolo(4,5-C:5',6'-g)azecin-13(5H)-one, 4,6,7,14-tetrahydro-5-methyl-15-methyl-7,9,19,21-tetraoxa-15-azapentacyclo(15.7.0.0^(4,12).0^(6,10).0^(18,22))tetracosa-1(24),4(12),5,10,17,22-hexaen-3-one15-methyl-7,9,19,21-tetraoxa-15-azapentacyclo(15.7.0.04,12.06,10.018,22)tetracosa-1(17),4,6(10),11,18(22),23-hexaen-3-one15-methyl-7,9,19,21-tetraoxa-15-azapentacyclo[15.7.0.0^{4,12}.0^{6,10}.0^{18,22}]tetracosa-1(24),4(12),5,10,17,22-hexaen-3-one15-methyl-7,9,19,21-tetraoxa-15-azapentacyclo(15.7.0.04,12.06,10.018,22)tetracosa-1(17),4(12),5,10,18(22),23-hexaen-3-oneHypercorine7-Methyl-6,7,8,9-tetrahydro-[1,3]dioxolo[4',5':5,6]benzo[1,2-c][1,3]dioxolo[5',4':4,5]benzo[1,2-g]azecin-15(16H)-one4,6,7,14-Tetrahydro-5-methylbis[1,3]benzodioxolo[4,5-c:5',6'-g]azecin-13(5H)-one7-methyl-6,8,9,16-tetrahydrobis[1,3]benzodioxolo[4,5-c:5',6'-g]azecin-15(7H)-one7-Methyl-6,8,9,16-tetrahydrodi[1,3]benzodioxolo[4,5-c:5,6-g]azecin-15(7H)-one
External Identifiers
EC NUMBER: 204-999-6DSSTOX SUBSTANCE ID: DTXSID90156282CHEMBL ID: CHEMBL453019CHEMBL ID: CHEMBL486179CHEBI ID: CHEBI:16415UNII: UIW569HT35HMDB ID: HMDB0003920KEGG ID: C05189METABOLOMICS WORKBENCH ID: 38412WIKIDATA ID: Q390706
Experimental Spectrum References
13C NMR Spectra1H NMR SpectraFTIR SpectraUV Spectra
Literature & Patent References
DOI 10.1016/j.bmc.2022.116705Isolation, synthesis and bioactivity evaluation of isoquinoline alkaloids from Corydalis hendersonii Hemsl. against gastric cancer in vitro and in vivo.PMID 35286954Isolation, synthesis and bioactivity evaluation of isoquinoline alkaloids from Corydalis hendersonii Hemsl. against gastric cancer in vitro and in vivo.DOI 10.1016/j.bmcl.2019.126642Antiprotozoal alkaloid principles of the plant family Amaryllidaceae.PMID 31515186Antiprotozoal alkaloid principles of the plant family Amaryllidaceae.DOI 10.1021/acs.jnatprod.7b00847Mucroniferanines A-G, Isoquinoline Alkaloids from Corydalis mucronifera.PMID 29400966Mucroniferanines A-G, Isoquinoline Alkaloids from Corydalis mucronifera.

Documentation & Compliance Facts

Compliance Facts

Shipment review: Required

Documentation available by request

Certificate of Analysis (COA): By request

Supplier Safety Data Sheet (SDS): By request

Purity and pack size confirmation: By request

Availability and lead time review: Confirmed by RFQ

Shipment documentation review: By request

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What happens after RFQ

  1. 1We review the CAS identity, quantity, and documentation request.
  2. 2We check sourcing options, supplier availability, COA/SDS, purity, pack size, and lead time.
  3. 3We review destination and shipment documentation needs when applicable.
  4. 4We follow up with a quotation or clarification request.

Text Reference Cues

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Non-public related references

BifendateCAS 73536-69-3

Non-public references are shown as text only and do not imply equivalence, availability, or shared use.

Catalog navigation

Related Catalog Entries

Other public CAS pages in this catalog. These links support navigation across additional intermediates and do not imply equivalence, availability, or shared use.

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RFQ questions for CAS 130-86-9

What are the key identifiers for Protopine (CAS 130-86-9)?

Protopine is identified by CAS 130-86-9, with molecular formula C20H19NO5, molecular weight 353.4, InChIKey GPTFURBXHJWNHR-UHFFFAOYSA-N.

Does CAS 130-86-9 have reported biological target evidence?

ChEMBL contains qualifying experimental assay evidence associated with Thyrotropin receptor, Cytochrome P450 3A4. These records do not establish therapeutic efficacy or clinical use.

Can I request a COA for CAS 130-86-9?

Yes. Submit an RFQ and specify COA requirements. Lot-specific COA depends on supplier confirmation.

Can I request supplier SDS for Protopine?

Yes. Supplier SDS can be requested through the RFQ workflow before handling, storage, shipment, or procurement decisions.

Is CAS 130-86-9 available for quotation?

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